Results 21 to 30 of about 84,900 (313)

Heparan Sulfate Structure in Mice with Genetically Modified Heparan Sulfate Production [PDF]

Journal of Biological Chemistry, 2004
Using a high throughput heparan sulfate (HS) isolation and characterization protocol, we have analyzed HS structure in several tissues from mice/mouse embryos deficient in HS biosynthesis enzymes (N-deacetylase/N-sulfotransferase (NDST)-1, NDST-2, and C5-epimerase, respectively) and in mice lacking syndecan-1.
Lena Kjellén, William D. Staatz, Scott B. Selleck, Johan Ledin, Dorothe Spillmann, Jin-Ping Li, Martin Götte   +6 more
openaire   +3 more sources

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

The Enzymatic Degradation of Heparan Sulfate [PDF]

Protein & Peptide Letters, 2017
Glycosaminoglycans (GAGs) such as heparan sulfate (HS) interact with a number of factors in the extracellular matrix (ECM) and as a consequence play a key role in the metabolic processes occurring within the cell. The dynamic synthesis and degradation of HS (and all GAGs) are necessary for ensuring that optimal chains are present for these functions ...
Griffin, Laura Susan, Gloster, Tracey Maureen   +1 more
openaire   +4 more sources

Heparan sulfate is a plasma biomarker of acute cellular allograft rejection. [PDF]

PLoS ONE, 2018
Despite advances in management of immunosuppression, graft rejection remains a significant clinical problem in solid organ transplantation. Non-invasive biomarkers of graft rejection can facilitate earlier diagnosis and treatment of acute rejection.
Andrew S Barbas, Liwen Lin, MacKenzie McRae, Andrea L MacDonald, Tracy Truong, Yiping Yang, Todd V Brennan   +6 more
doaj   +1 more source

Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]

, 2013
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Burhan, I, Funck, M, Huang, L, Johnson, TS, Scarpellini, A, Schroeder, N, Verderio, EAM   +6 more
core   +1 more source

Heparan sulfate: Antithrombotic or not? [PDF]

Journal of Clinical Investigation, 2003
With their studies in 3-OST-1 knockout mice, HajMohammadi and colleagues (15) have advanced our understanding of the pathways that regulate thrombin. Antithrombin is critical for thrombin regulation because even partial deficiency is associated with thrombosis.
openaire   +3 more sources

Heparan sulfate proteoglycans at a glance [PDF]

Journal of Cell Science, 2007
Proteoglycans are abundant components of the cell surface and extracellular matrix that mediate critical interactions between cells and their environment. They play a variety of biological roles in normal tissues and in response to injury and disease.
Scott B. Selleck, Catherine Kirkpatrick
openaire   +3 more sources

Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity [PDF]

, 2015
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate ...
Brinkmann, Volker, Chang, Yung-Chi, Cole, Jason N, Esko, Jeffrey D, Nizet, Victor, Olson, Joshua, van Wijk, Xander M, Xu, Ding, Zychlinsky, Arturo   +8 more
core   +1 more source

A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation [PDF]

Glycobiology, 2022
Abstract NDST1 (glucosaminyl N-deacetylase/N-sulfotransferase) is a key enzyme in heparan sulfate (HS) biosynthesis, where it is responsible for HS N-deacetylation and N-sulfation. In addition to the full length human enzyme of 882 amino acids, here designated NDST1A, a shorter form containing 825 amino acids (NDST1B) is synthesized ...
Parisa Missaghian, Tabea Dierker, Elham Khosrowabadi, Fredrik Axling, Inger Eriksson, Abdurrahman Ghanem, Marion Kusche-Gullberg, Sakari Kellokumpu, Lena Kjellén   +8 more
openaire   +7 more sources

The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men

Frontiers in Immunology, 2017
Thoracoabdominal aortic aneurysm (TAAA) is a highly lethal disorder requiring open or endovascular TAAA repair, both of which are rare, but extensive and complex surgical procedures associated with a significant systemic inflammatory response and high ...
Lukas Martin, Lukas Martin, Alexander Gombert, Jianmin Chen, Julia Liebens, Julia Verleger, Johannes Kalder, Gernot Marx, Michael Jacobs, Christoph Thiemermann, Tobias Schuerholz, Tobias Schuerholz   +11 more
doaj   +1 more source