Results 21 to 30 of about 81,640 (295)

Heparan Sulfate Structure in Mice with Genetically Modified Heparan Sulfate Production [PDF]

Journal of Biological Chemistry, 2004
Using a high throughput heparan sulfate (HS) isolation and characterization protocol, we have analyzed HS structure in several tissues from mice/mouse embryos deficient in HS biosynthesis enzymes (N-deacetylase/N-sulfotransferase (NDST)-1, NDST-2, and C5-epimerase, respectively) and in mice lacking syndecan-1.
Lena Kjellén, William D. Staatz, Scott B. Selleck, Johan Ledin, Dorothe Spillmann, Jin-Ping Li, Martin Götte   +6 more
openaire   +3 more sources

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides [PDF]

, 2020
Despite evident regulatory roles of heparan sulfate (HS) saccharides in numerous biological processes, definitive information on the bioactive sequences of these polymers is lacking, with only a handful of natural structures sequenced to date.
Grabarics, Márkó, Guimond, Scott E., Hofmann, Johanna, Manz, Christian, Miller, Rebecca L., Pagel, Kevin, Schwörer, Ralf, Tyler, Peter C., Xu, Yongmei [u.v.m.], Zubkova, Olga V.   +9 more
core   +1 more source

The Enzymatic Degradation of Heparan Sulfate [PDF]

Protein & Peptide Letters, 2017
Glycosaminoglycans (GAGs) such as heparan sulfate (HS) interact with a number of factors in the extracellular matrix (ECM) and as a consequence play a key role in the metabolic processes occurring within the cell. The dynamic synthesis and degradation of HS (and all GAGs) are necessary for ensuring that optimal chains are present for these functions ...
Griffin, Laura Susan, Gloster, Tracey Maureen   +1 more
openaire   +4 more sources

Heparan sulfate: Antithrombotic or not? [PDF]

Journal of Clinical Investigation, 2003
With their studies in 3-OST-1 knockout mice, HajMohammadi and colleagues (15) have advanced our understanding of the pathways that regulate thrombin. Antithrombin is critical for thrombin regulation because even partial deficiency is associated with thrombosis.
openaire   +3 more sources

Heparan sulfate proteoglycans at a glance [PDF]

Journal of Cell Science, 2007
Proteoglycans are abundant components of the cell surface and extracellular matrix that mediate critical interactions between cells and their environment. They play a variety of biological roles in normal tissues and in response to injury and disease.
Scott B. Selleck, Catherine Kirkpatrick
openaire   +3 more sources

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function. [PDF]

, 2019
The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Chen, Jihuan, Chen, Valerie, Hoang, Ivy, Kawamura, Tomoya, McBride, Ryan, Millhauser, Glenn L, Repunte-Canonigo, Vez, Sanna, Pietro Paolo, Wong, Ashley Tess, Yang, Yang   +9 more
core   +1 more source

Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis [PDF]

, 2013
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. The interaction of TG2 with the heparan sulfate proteoglycan syndecan-4 (Sdc4) regulates the cell surface trafficking, localization, and ...
Burhan, I, Funck, M, Huang, L, Johnson, TS, Scarpellini, A, Schroeder, N, Verderio, EAM   +6 more
core   +1 more source

Agrin Is a Heparan Sulfate Proteoglycan [PDF]

Journal of Biological Chemistry, 1995
In the present study we have identified the extracellular matrix protein agrin as a major heparan sulfate proteoglycan (HSPG) in embryonic chick brain. Using monoclonal antibodies and a polyclonal antiserum to the core protein of a previously identified HSPG from embryonic chick brain, our expression screened a random-primed E9 chick brain cDNA library.
Gregory J. Cole, Guoshan Tsen, Willi Halfter, Stephan Kröger   +3 more
openaire   +2 more sources

Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity [PDF]

, 2015
Recently, we showed that endothelial heparan sulfate facilitates entry of a bacterial pathogen into the central nervous system. Here, we show that normal bactericidal activity of neutrophils is influenced by the sulfation pattern of heparan sulfate ...
Brinkmann, Volker, Chang, Yung-Chi, Cole, Jason N, Esko, Jeffrey D, Nizet, Victor, Olson, Joshua, van Wijk, Xander M, Xu, Ding, Zychlinsky, Arturo   +8 more
core   +1 more source

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +1 more source