Results 21 to 30 of about 39,661 (194)
A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis
Molecular Cancer, 2010 Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish +6 more
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Removal of cell surface heparan sulfate increases TACE activity and cleavage of ErbB4 receptor
BMC Cell Biology, 2009 Background Nuclear localization of proteolytically formed intracellular fragment of ErbB4 receptor tyrosine kinase has been shown to promote cell survival, and nuclear localization of ErbB4 receptor has been described in human breast cancer.
Tuittila Minna T +5 more
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Molecules, 2017 Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim +2 more
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G3: Genes, Genomes, Genetics, 2020 Autophagy is a catabolic process that provides cells with energy and molecular building blocks during nutritional stress. Autophagy also removes misfolded proteins and damaged organelles, a critical mechanism for cellular repair.
Claire Reynolds-Peterson +11 more
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Frontiers in Physiology, 2018 The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular ...
M. F. Galvis-Ramírez +2 more
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Regulation of pathologic retinal angiogenesis in mice and inhibition of VEGF-VEGFR2 binding by soluble heparan sulfate. [PDF]
PLoS ONE, 2010 Development of the retinal vascular network is strictly confined within the neuronal retina, allowing the intraocular media to be optically transparent. However, in retinal ischemia, pro-angiogenic factors (including vascular endothelial growth factor-A,
Koji M Nishiguchi +4 more
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Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation [PDF]
Proceedings of the National Academy of Sciences, 2008 Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology through interactions with protein ligands. The interactions depend on HS structure, which is determined largely during biosynthesis by Golgi enzymes. How biosynthesis is regulated is more or less unknown.
Jenny, Presto +7 more
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Graft glycocalyx degradation in human liver transplantation.
PLoS ONE, 2019 ObjectiveIschaemia/reperfusion-injury degrades endothelial glycocalyx. Graft glycocalyx degradation was studied in human liver transplantation.MethodsTo assess changes within the graft, blood was drawn from portal and hepatic veins in addition to ...
Arie Passov +6 more
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Bio-Protocol, 2017 Heparan sulfate (HS) is purified from complex matrices and often not fully characterised to validate its assignment. The characterisation of heparins and heparan sulfates through enzymatic depolymerisation and subsequent strong anion-exchange high ...
Susan Carnachan, Simon F.R. Hinkley
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Structural Analysis of Heparan Sulfate and Heparan Sulfate Oligosaccharides.
Trends in Glycoscience and Glycotechnology, 1998 ヘパラン硫酸は構造的に複雑な生体内高分子で、様々な重要な生物活性発現に関わる可能性が認められ、最近活発に研究されるようになった。ヘパラン硫酸の生物活性発現はグリコサミノグリカン糖鎖による。このグリコサミノグリカンは、複雑な構造多様性を示す二糖単位から構成され、その糖鎖長も一定でない。この複雑な糖鎖を構造決定しようとする試みは、あらゆる方法を用いて遂行されたにもかかわらず、未だ達成されていない。最近のヘパラン硫酸糖鎖構造に関する研究は、もっぱらある種の生物活性を示す最小糖鎖配列を高分子部分から切り出し、その構造を同定することに焦点が絞られている。このミニレビューでは、ヘパラン硫酸由来のオリゴ糖鎖の調製、単離および構造決定法について最近の文献を挙げ、総説する。特に、高速液体クロマトグラフィー ...
Toshihiko Toida, R. J. Linhardt
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