Results 21 to 30 of about 465,990 (261)
Infection and transmission of SARS‐CoV‐2 depend on heparan sulfate proteoglycans
EMBO Journal, 2021 The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and outbreaks of new variants highlight the need for preventive treatments. Here, we identified heparan sulfate proteoglycans as attachment receptors for SARS‐CoV‐
Marta Bermejo-Jambrina +14 more
semanticscholar +1 more source
A Systems View of the Heparan Sulfate Interactome
Journal of Histochemistry and Cytochemistry, 2021 Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains.
Alejandro Gómez Toledo +5 more
semanticscholar +1 more source
Single-molecule force spectroscopy reveals structural differences of heparan sulfate chains during binding to vitronectin [PDF]
Phys. Rev. E 104, 024409 (2021), 2021 The syndecans represent an ongoing research field focused on their regulatory roles in normal and pathological conditions. Syndecan's role in cancer progression becomes well-documented, implicating their importance in diagnosis and even proposing various cancer potential treatments.
arxiv +1 more source
Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. [PDF]
, 2011 Sanfilippo syndrome type B (MPS IIIB) is characterized by profound mental retardation in childhood, dementia and death in late adolescence; it is caused by deficiency of α-N-acetylglucosaminidase and resulting lysosomal storage of heparan sulfate.
Neufeld, Elizabeth F +2 more
core +10 more sources
Heparin Mimetics and Their Impact on Extracellular Matrix Protein Assemblies
Pharmaceuticals, 2023 Heparan sulfate is a crucial extracellular matrix component that organizes structural features and functional protein processes. This occurs through the formation of protein–heparan sulfate assemblies around cell surfaces, which allow for the deliberate ...
Fabian Heide +2 more
doaj +1 more source
Potential Use of Anti-Inflammatory Synthetic Heparan Sulfate to Attenuate Liver Damage
Biomedicines, 2020 Heparan sulfate is a highly sulfated polysaccharide abundant on the surface of hepatocytes and surrounding extracellular matrix. Emerging evidence demonstrates that heparan sulfate plays an important role in neutralizing the activities of proinflammatory
Katelyn Arnold, Yi-En Liao, Jian Liu
doaj +1 more source
Biomedicines, 2022 White adipose tissues are major endocrine organs that release factors, termed adipokines, which affect other major organ systems. The development and functions of adipose tissues depend largely upon the glycosaminoglycan heparan sulfate.
J. Michael Sorrell, Arnold I. Caplan
doaj +1 more source
MASP-2 Is a Heparin-Binding Protease; Identification of Blocking Oligosaccharides
Frontiers in Immunology, 2020 It is well-known that heparin and other glycosaminoglycans (GAGs) inhibit complement activation. It is however not known whether fractionation and/or modification of GAGs might deliver pathway-specific inhibition of the complement system.
Ditmer T. Talsma +15 more
doaj +1 more source
Frontiers in Oncology, 2020 Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation of secondary tumors. This process is complex and is spatially and temporally regulated by intrinsic and extrinsic factors.
Z. Elgundi +6 more
semanticscholar +1 more source
Endothelial glycocalyx during early reperfusion in patients undergoing cardiac surgery.
PLoS ONE, 2021 BackgroundExperimental cardiac ischemia-reperfusion injury causes degradation of the glycocalyx and coronary washout of its components syndecan-1 and heparan sulfate.
Arie Passov +5 more
doaj +1 more source