Results 41 to 50 of about 42,021 (263)
Brazilian Journal of Medical and Biological Research, 2001 The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed.
H.B. Nader +12 more
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Nature Communications, 2021 Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of ...
Maria De Risi +19 more
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Heparin and Heparan Sulfate Biosynthesis [PDF]
IUBMB Life, 2002 AbstractHeparan sulfate is one of the most informationally rich biopolymers in Nature. Its simple sugar backbone is variously modified to different degrees depending on the cellular conditions. Thus, it matures to have an enormously complicated structure, which most likely exhibits a considerable number of unique overlapping sequences with peculiar ...
Kazuyuki Sugahara, Hiroshi Kitagawa
openaire +2 more sources
Heparan Sulfate-Dependent Enhancement of Henipavirus Infection
mBio, 2015 Nipah virus and Hendra virus are emerging, highly pathogenic, zoonotic paramyxoviruses that belong to the genus Henipavirus. They infect humans as well as numerous mammalian species.
Cyrille Mathieu +9 more
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Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling [PDF]
Brazilian Journal of Medical and Biological Research, 2006 The syndecans, heparan sulfate proteoglycans, are abundant molecules associated with the cell surface and extracellular matrix and consist of a protein core to which heparan sulfate chains are covalently attached. Each of the syndecan core proteins has a
C.C. Lopes, C.P. Dietrich, H.B. Nader
doaj +1 more source
Scientific Reports, 2022 Recent reports demonstrate that SARS-CoV-2 utilizes cell surface heparan sulfate as an attachment factor to facilitate the initial interaction with host cells.
Yulia Kiyan +6 more
doaj +1 more source
Fibroblast EXT1-levels influence tumor cell proliferation and migration in composite spheroids. [PDF]
PLoS ONE, 2012 BACKGROUND: Stromal fibroblasts are important determinants of tumor cell behavior. They act to condition the tumor microenvironment, influence tumor growth, support tumor angiogenesis and affect tumor metastasis.
Cecilia Österholm +6 more
doaj +1 more source
Protease, Growth Factor, and Heparanase-Mediated Syndecan-1 Shedding Leads to Enhanced HSV-1 Egress
Viruses, 2021 Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are considered important for the entry of many different viruses. Previously, we demonstrated that heparanase (HPSE), the host enzyme responsible for cleaving HS chains, is upregulated by ...
Ghadah A. Karasneh +4 more
doaj +1 more source
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
Expression Pattern of Sulf1 and Sulf2 in Chicken Tissues and Characterization of Their Expression During Different Periods in Skeletal Muscle Satellite Cells [PDF]
Brazilian Journal of Poultry ScienceHeparan sulfate proteoglycans (HSPGs) are present on the cell surface and in the extracellular matrix in all metazoans. HSPGs interact with growth factors and receptors through heparan sulfate (HS) chains.
L He +8 more
doaj +2 more sources