Results 51 to 60 of about 465,990 (261)
Molecules, 2017 Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim +2 more
doaj +1 more source
Effects of receptor clustering on ligand dissociation: Theory and simulations [PDF]
Biophys. J. 89 (2005) 3685, 2004 Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptors may be facilitated by heterogeneous zones of lipids, known as lipid rafts.
arxiv +1 more source
The role of heparan sulfate in enhancing the chemotherapeutic response in triple-negative breast cancer. [PDF]
Breast Cancer ResBackground Breast cancer, one of the most common forms of cancer, is associated with the highest cancer-related mortality among women worldwide. In comparison to other types of breast cancer, patients diagnosed with the triple-negative breast cancer ...
Manouchehri JM +12 more
europepmc +2 more sources
Evidence for the role of proteoglycans in cation-mediated gene transfer [PDF]
, 1996 We report evidence that gene complexes, consisting of polycations and plasmid DNA enter cells via binding to membrane-associated proteoglycans. Treatment of HeLa cells with sodium chlorate, a potent inhibitor of proteoglycan sulfation, reduced luciferase
Baldeschwieler, John D. +1 more
core +1 more source
Bio-Protocol, 2017 Heparan sulfate (HS) is purified from complex matrices and often not fully characterised to validate its assignment. The characterisation of heparins and heparan sulfates through enzymatic depolymerisation and subsequent strong anion-exchange high ...
Susan Carnachan, Simon F.R. Hinkley
doaj +1 more source
Circulating heparan sulfate fragments mediate septic cognitive dysfunction
Journal of Clinical Investigation, 2019 Septic patients frequently develop cognitive impairment that persists beyond hospital discharge. The impact of sepsis on electrophysiological and molecular determinants of learning is underexplored.
J. Hippensteel +16 more
semanticscholar +1 more source
Graft glycocalyx degradation in human liver transplantation.
PLoS ONE, 2019 ObjectiveIschaemia/reperfusion-injury degrades endothelial glycocalyx. Graft glycocalyx degradation was studied in human liver transplantation.MethodsTo assess changes within the graft, blood was drawn from portal and hepatic veins in addition to ...
Arie Passov +6 more
doaj +1 more source
Three-fold mechanism of inhibition of SARS-CoV-2 infection by the interaction of the spike glycoprotein with heparin [PDF]
arXiv, 2021 Heparin has been found to have antiviral activity against SARS-CoV-2. Here, by means of sliding window docking, molecular dynamics simulations and biochemical assays, we investigate the binding mode of heparin to the virus spike glycoprotein and the molecular basis for its antiviral activity.
arxiv
Nature Communications, 2019 The proteoglycan Syndecan-2 (Sdc2) has been implicated in regulation of cytoskeleton organization, integrin signaling and developmental angiogenesis in zebrafish.
F. Corti +11 more
semanticscholar +1 more source
Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions. [PDF]
, 2012 International audienceBACKGROUND: Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted ...
Arenzana-Seisdedos, Fernando +11 more
core +3 more sources