Results 51 to 60 of about 81,640 (295)

Graft glycocalyx degradation in human liver transplantation.

PLoS ONE, 2019
ObjectiveIschaemia/reperfusion-injury degrades endothelial glycocalyx. Graft glycocalyx degradation was studied in human liver transplantation.MethodsTo assess changes within the graft, blood was drawn from portal and hepatic veins in addition to ...
Arie Passov, Alexey Schramko, Heikki Mäkisalo, Arno Nordin, Sture Andersson, Eero Pesonen, Minna Ilmakunnas   +6 more
doaj   +1 more source

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Brazilian Journal of Medical and Biological Research, 2001
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed.
H.B. Nader, M.A.S. Pinhal, E.C. Baú, R.A.B. Castro, G.F. Medeiros, S.F. Chavante, E.L. Leite, E.S. Trindade, S.K. Shinjo, H.A.O. Rocha, I.L.S. Tersariol, A. Mendes, C.P. Dietrich   +12 more
doaj   +1 more source

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Nature Communications, 2021
Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of ...
Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibus   +19 more
doaj   +1 more source

Heparin and Heparan Sulfate Biosynthesis [PDF]

IUBMB Life, 2002
AbstractHeparan sulfate is one of the most informationally rich biopolymers in Nature. Its simple sugar backbone is variously modified to different degrees depending on the cellular conditions. Thus, it matures to have an enormously complicated structure, which most likely exhibits a considerable number of unique overlapping sequences with peculiar ...
Kazuyuki Sugahara, Hiroshi Kitagawa
openaire   +2 more sources

Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions. [PDF]

, 2012
International audienceBACKGROUND: Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted ...
Arenzana-Seisdedos, Fernando, Baleux, Françoise, Chretien, Fabrice, Gasse, Pamela, Guérin, Coralie, Lortat-Jacob, Hugues, Richart, Adèle, Rueda, Patricia, Récalde, Alice, Silvestre, Jean-Sébastien, Vieira, Paulo, Vilar, José   +11 more
core   +3 more sources

Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate

Scientific Reports, 2022
Recent reports demonstrate that SARS-CoV-2 utilizes cell surface heparan sulfate as an attachment factor to facilitate the initial interaction with host cells.
Yulia Kiyan, Anna Schultalbers, Ekaterina Chernobrivaia, Sergey Tkachuk, Song Rong, Nelli Shushakova, Hermann Haller   +6 more
doaj   +1 more source

Protease, Growth Factor, and Heparanase-Mediated Syndecan-1 Shedding Leads to Enhanced HSV-1 Egress

Viruses, 2021
Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are considered important for the entry of many different viruses. Previously, we demonstrated that heparanase (HPSE), the host enzyme responsible for cleaving HS chains, is upregulated by ...
Ghadah A. Karasneh, Divya Kapoor, Navya Bellamkonda, Chandrashekhar D. Patil, Deepak Shukla   +4 more
doaj   +1 more source

Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]

, 2012
Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G., Broek, L.A.M., van den, Chavaroche, A.A.E., Eggink, G.   +3 more
core   +2 more sources

Heparan Sulfate-Dependent Enhancement of Henipavirus Infection

mBio, 2015
Nipah virus and Hendra virus are emerging, highly pathogenic, zoonotic paramyxoviruses that belong to the genus Henipavirus. They infect humans as well as numerous mammalian species.
Cyrille Mathieu, Kévin P. Dhondt, Marie Châlons, Stéphane Mély, Hervé Raoul, Didier Negre, François-Loïc Cosset, Denis Gerlier, Romain R. Vivès, Branka Horvat   +9 more
doaj   +1 more source

Glycosaminoglycans in the human cornea: age-related changes [PDF]

, 2015
AIM: To investigate possible age-related changes in glycosaminoglycans (GAGs) in the human cornea. The substances today called GAGs were previously referred to as mucopolysaccharides.
Anello, Giulia, Cavallotti, Carlo, De Paolis, Giulio, Pacella, Elena, Pacella, Fernanda, Parisella, Francesca Romana, Turchetti, Paolo   +6 more
core   +2 more sources