Results 61 to 70 of about 465,990 (261)

Development of new heparin-like compounds and other antithrombotic drugs and their interaction with vascular endothelial cells

Brazilian Journal of Medical and Biological Research, 2001
The anticlotting and antithrombotic activities of heparin, heparan sulfate, low molecular weight heparins, heparin and heparin-like compounds from various sources used in clinical practice or under development are briefly reviewed.
H.B. Nader, M.A.S. Pinhal, E.C. Baú, R.A.B. Castro, G.F. Medeiros, S.F. Chavante, E.L. Leite, E.S. Trindade, S.K. Shinjo, H.A.O. Rocha, I.L.S. Tersariol, A. Mendes, C.P. Dietrich   +12 more
doaj   +1 more source

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Nature Communications, 2021
Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of ...
Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibus   +19 more
doaj   +1 more source

Heparan Sulfates and Heparan Sulfate Proteoglycans in Hematopoiesis.

Blood
From signaling mediators in stem cells, to markers of differentiation and lineage commitment, to facilitators for the entry of viruses like HIV-1, cell surface heparan sulfate (HS) glycans with their distinct modification patterns play important roles in
Richard T. Piszczatowski, Hannes Erich Buelow, Ulrich Steidl   +2 more
semanticscholar   +1 more source

Glycosaminoglycans in the human cornea: age-related changes [PDF]

, 2015
AIM: To investigate possible age-related changes in glycosaminoglycans (GAGs) in the human cornea. The substances today called GAGs were previously referred to as mucopolysaccharides.
Anello, Giulia, Cavallotti, Carlo, De Paolis, Giulio, Pacella, Elena, Pacella, Fernanda, Parisella, Francesca Romana, Turchetti, Paolo   +6 more
core   +2 more sources

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity

Frontiers in Molecular Neuroscience, 2018
Neural circuits consist of distinct neuronal cell types connected in specific patterns. The specificity of these connections is achieved in a series of sequential developmental steps that involve the targeting of neurites, the identification of synaptic ...
G. Condomitti, Joris de Wit
semanticscholar   +1 more source

Protease, Growth Factor, and Heparanase-Mediated Syndecan-1 Shedding Leads to Enhanced HSV-1 Egress

Viruses, 2021
Heparan sulfate (HS) and heparan sulfate proteoglycans (HSPGs) are considered important for the entry of many different viruses. Previously, we demonstrated that heparanase (HPSE), the host enzyme responsible for cleaving HS chains, is upregulated by ...
Ghadah A. Karasneh, Divya Kapoor, Navya Bellamkonda, Chandrashekhar D. Patil, Deepak Shukla   +4 more
doaj   +1 more source

Heparan sulfate as a regulator of inflammation and immunity

Journal of Leukocyte Biology, 2018
Heparan sulfate is found on the surface of most cell types, as well as in basement membranes and extracellular matrices. Its strong anionic properties and highly variable structure enable this glycosaminoglycan to provide binding sites for numerous ...
L. Collins, L. Troeberg
semanticscholar   +1 more source

Synthesis of heparosan oligosaccharides by Pasteurella multocida PmHS2 single-action transferases [PDF]

, 2012
Pasteurella multocida heparosan synthase PmHS2 is a dual action glycosyltransferase that catalyzes the polymerization of heparosan polymers in a non-processive manner.
Boeriu, C.G., Broek, L.A.M., van den, Chavaroche, A.A.E., Eggink, G.   +3 more
core   +2 more sources

Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate

Scientific Reports, 2022
Recent reports demonstrate that SARS-CoV-2 utilizes cell surface heparan sulfate as an attachment factor to facilitate the initial interaction with host cells.
Yulia Kiyan, Anna Schultalbers, Ekaterina Chernobrivaia, Sergey Tkachuk, Song Rong, Nelli Shushakova, Hermann Haller   +6 more
doaj   +1 more source

Heparan Sulfate Proteoglycans in Human Colorectal Cancer

Analytical Cellular Pathology, 2018
Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year. Prognosis of patients is highly dependent on the disease stage at diagnosis.
C. Vicente, Daiana Aparecida da Silva, P. V. Sartorio, T. D. Silva, S. Saad, H. Nader, N. Forones, L. Toma   +7 more
semanticscholar   +1 more source