Homeodomain Proteins Directly Regulate ATM Kinase Activity [PDF]
Cell Reports, 2018 Summary: Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress.
Tanya E. Johnson +8 more
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Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity [PDF]
eLife, 2021 How our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. Using Drosophila lamina neuron types (L1-L5), we show that the primary homeodomain transcription factor (HDTF) brain-specific homeobox (Bsh) is ...
Chundi Xu +4 more
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Homeodomain proteins: an update. [PDF]
Chromosoma, 2016 Here, we provide an update of our review on homeobox genes that we wrote together with Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have become possible due to genome sequencing projects. Using the 103 Drosophila homeobox genes as example, we present an updated classification. In animals, there are 16 major classes, ANTP,
Bürglin TR, Affolter M.
europepmc +5 more sources
Global Analysis of Intercellular Homeodomain Protein Transfer [PDF]
Cell Reports, 2019 Summary: The homeodomain is found in hundreds of transcription factors that play roles in fate determination via cell-autonomous regulation of gene expression.
Eun Jung Lee +12 more
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Regulation of Silk Genes by Hox and Homeodomain Proteins in the Terminal Differentiated Silk Gland of the Silkworm Bombyx mori [PDF]
Journal of Developmental Biology, 2016 The silk gland of the silkworm Bombyx mori is a long tubular organ that is divided into several subparts along its anteroposterior (AP) axis. As a trait of terminal differentiation of the silk gland, several silk protein genes are expressed with unique ...
Shigeharu Takiya +2 more
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Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues.
Bhavya Shetty +5 more
doaj +2 more sources
Drosophila Homeodomain-Interacting Protein Kinase (Hipk) Phosphorylates the Homeodomain Proteins Homeobrain, Empty Spiracles, and Muscle Segment Homeobox. [PDF]
Int J Mol Sci, 2019 The Drosophila homeodomain-interacting protein kinase (Hipk) is the fly representative of the well-conserved group of HIPKs in vertebrates. It was initially found through its characteristic interactions with homeodomain proteins. Hipk is involved in a variety of important developmental processes, such as the development of the eye or the nervous system.
Steinmetz EL +3 more
europepmc +4 more sources
Deciphering the pathogenicity of three NKX2-1 variants in ultra-severe forms of childhood interstitial lung disease. [PDF]
PLoS ONEIntroductionThe transcription factor NK2 homeobox1 (NKX2-1), associated with brain lung thyroid syndrome, regulates the transcription of surfactant proteins, thyroglobulin (TG) and thyroid peroxidase (TPO).
Yohan David Soreze +12 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Transcription factors (TFs) guide effector proteins like chromatin-modifying or -remodeling enzymes to distinct sites in the genome and thereby fulfill important early steps in translating the genome’s sequence information into the production of proteins
Marina Reichlmeir +2 more
doaj +1 more source
Molecular Analysis of the HOXA2-Dependent Degradation of RCHY1. [PDF]
PLoS ONE, 2015 The homeodomain transcription factor Hoxa2 interacts with the RING-finger type E3 ubiquitin ligase RCHY1 and induces its proteasomal degradation. In this work, we dissected this non-transcriptional activity of Hoxa2 at the molecular level.
Laure Bridoux +3 more
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