Results 91 to 100 of about 65,477 (225)

Expression of neurogenin3 reveals an islet cell precursor population in the pancreas [PDF]

, 2000
Differentiation of early gut endoderm cells into the endocrine cells forming the pancreatic islets of Langerhans depends on a cascade of gene activation events controlled by transcription factors including the basic helix-loop-helix (bHLH) proteins.
Anderson, David J., Conners, Jennifer R., German, Michael S., Johnson, Jeffrey D., Kalamaras, Julie, Lee, Jacqueline E., Scheel, David W., Schwitzgebel, Valérie M., Sussel, Lori   +8 more
core  

The structure of an LIM-only protein 4 (LMO4) and deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4 [PDF]

, 2016
LIM-domain only protein 4 (LMO4) is a widely expressed protein with important roles in embryonic development and breast cancer. It has been reported to bind many partners, including the transcription factor Deformed epidermal autoregulatory factor-1 ...
Cubeddu, Liza, Joseph, Soumya, Kwan, Ann H., Mackay, Joel P., Matthews, Jacqueline M., Stokes, Philippa H.   +5 more
core   +1 more source

The HOXC6 homeodomain-containing proteins.

The international journal of biochemistry & cell biology, 1998
The HOXC6 homeodomain-containing proteins act as transcription factors in the genetic control of multiple genes involved in development and cell differentiation. Two HOXC6 polypeptides are encoded by a single homeobox ('HOX') gene described as 'master gene' for the crucial role it plays in the patterning and axial morphogenesis of multiple species ...
Chariot, Alain, Gielen, jacques
openaire   +2 more sources

Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C [PDF]

FEBS Letters, 2001
The Dlx3 homeodomain gene is expressed in terminally differentiated murine epidermal cells. As demonstrated for differentiation‐specific granular markers, Dlx3 is activated in primary mouse keratinocytes cultured in vitro by increasing the level of the extracellular Ca2+.
Park, Geon Tae, Denning, Mitchell F., Morasso, Maria I.   +2 more
openaire   +2 more sources

Hox Gene Variation Drives Morphological Specialization of Humpback Grouper Cromileptes altivelis

Integrative Zoology, EarlyView.
Cromileptes altivelis exhibits a distinctive “sunken head and humpback” morphology, formed through cranial remodeling. Genetic analyses identified unique amino acid variants in Hoxa7a and Hoxa10b, with functional tests confirming their role in enhancing osteoblast activity and driving cranial remodeling.
Xiaoying Cao, Zhaowei Zhong, Lisheng Wu, Quanyin Liu, Shaoxiong Ding   +4 more
wiley   +1 more source

Pattern formation during de novo assembly of the Arabidopsis shoot meristem [PDF]

, 2007
Most multicellular organisms have a capacity to regenerate tissue after wounding. Few, however, have the ability to regenerate an entire new body from adult tissue. Induction of new shoot meristems from cultured root explants is a widely used, but poorly
Das, Pradeep, Gordon, Sean P., Heisler, Marcus G., Meyerowitz, Elliot M., Ohno, Carolyn, Reddy, G. Venugopala   +5 more
core   +2 more sources

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

The ALX4 dimer structure provides insight into how disease alleles impact function

Nature Communications
How homeodomain proteins gain sufficient DNA binding specificity to regulate diverse processes is a long-standing question. Here, we determine how the ALX4 Paired-like protein achieves DNA binding specificity for a TAAT–NNN–ATTA dimer site. We first show
Brittany Cain, Zhenyu Yuan, Evelyn Thoman, Rhett A. Kovall, Brian Gebelein   +4 more
doaj   +1 more source

Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia

The FEBS Journal, EarlyView.
Genetic rearrangements resulting in the expression of KMT2A fusion alleles can lead to dramatic transcriptional disturbances that contribute to the onset of acute leukaemias. Fortunately, menin inhibition has emerged as a promising new class of targeted therapy.
Lydia Elaine Roets, Graeme Greenfield, Katrina Mairead Lappin   +2 more
wiley   +1 more source

A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina

Neural Development, 2007
Background Otx genes, orthologues of the Drosophila orthodenticle gene (otd), play crucial roles in vertebrate brain development. In the Xenopus eye, Xotx2 and Xotx5b promote bipolar and photoreceptor cell fates, respectively.
He Rong-Qiao, Liu Yang, Cremisi Federico, Onorati Marco, Barsacchi Giuseppina, Vignali Robert   +5 more
doaj   +1 more source