Results 11 to 20 of about 65,477 (225)
DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers [PDF]
, 2010 Protein self-organization is essential for the establishment and maintenance of nuclear architecture and for the regulation of gene expression. We have shown previously that the Proline-Rich Homeodomain protein (PRH/Hex) self-assembles to form oligomeric
A. Sawasdichai +41 more
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Scientific Reports, 2023 HMX3 is a homeodomain protein with essential roles in CNS and ear development. Homeodomains are DNA-binding domains and hence homeodomain-containing proteins are usually assumed to be transcription factors.
William Haws +6 more
doaj +1 more source
Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Rice, K.L. +4 more
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The roles of HD-ZIP proteins in plant abiotic stress tolerance
Frontiers in Plant Science, 2022 Homeodomain leucine zipper (HD-ZIP) proteins are plant-specific transcription factors that contain a homeodomain (HD) and a leucine zipper (LZ) domain.
Yuxia Li +7 more
doaj +1 more source
Unconventional Secretion, Gate to Homeoprotein Intercellular Transfer
Frontiers in Cell and Developmental Biology, 2022 Unconventional secretion allows for the secretion of fully mature and biologically active proteins mostly present in the cytoplasm or nucleus. Besides extra vesicle-driven secretion, non-extravesicular pathways also exist that specifically rely on the ...
Alain Joliot, Alain Prochiantz
doaj +1 more source
Molecular Systems Biology, 2022 The correct wiring of neuronal circuits is one of the most complex processes in development, since axons form highly specific connections out of a vast number of possibilities. Circuit structure is genetically determined in vertebrates and invertebrates,
Jessica Velten +8 more
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A Petunia homeodomain-leucine zipper protein, PhHD-Zip, plays an important role in flower senescence. [PDF]
, 2014 Flower senescence is initiated by developmental and environmental signals, and regulated by gene transcription. A homeodomain-leucine zipper transcription factor, PhHD-Zip, is up-regulated during petunia flower senescence. Virus-induced gene silencing of
Chang, Xiaoxiao +5 more
core +7 more sources
HOPX: The Unusual Homeodomain-Containing Protein [PDF]
Journal of Investigative Dermatology, 2016 The homeodomain-only protein homeobox (HOPX) is the smallest known member of the homeodomain-containing protein family, atypically unable to bind DNA. HOPX is widely expressed in diverse tissues, where it is critically involved in the regulation of proliferation and differentiation.
Anita, Mariotto +4 more
openaire +2 more sources
Homeodomain Proteins: Cooperating to be different [PDF]
Current Biology, 1995 The product of the Drosophila extradenticle gene interacts cooperatively with homeodomain proteins encoded by homeotic selector genes, and may account in part for their distinct regulatory properties.
Wilson, David S., Desplan, Claude
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A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. [PDF]
PLoS ONE, 2009 The CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to
Jeffrey T Irelan +6 more
doaj +1 more source