Results 21 to 30 of about 65,477 (225)

ADP ribosylation by PARP-1 suppresses HOXB7 transcriptional activity. [PDF]

PLoS ONE, 2012
Interactions with cofactors regulate transcriptional activity and also help HOX proteins to achieve the specificity required for transcriptional regulation of target genes. In this study, we describe a novel protein/protein interaction of HOXB7 with poly
Xinyan Wu, Stephan Ellmann, Ethel Rubin, Minchan Gil, Kideok Jin, Liangfeng Han, Hexin Chen, Erika M Kwon, Jianhui Guo, Hyo Chol Ha, Saraswati Sukumar   +10 more
doaj   +1 more source

An NKX-COUP-TFII morphogenetic code directs mucosal endothelial addressin expression

Nature Communications, 2022
Vascular addressins control lymphocyte homing, thus regulating immunity and inflammation, but how addressin expression is patterned remains unknown.
Thanh Theresa Dinh, Menglan Xiang, Anusha Rajaraman, Yongzhi Wang, Nicole Salazar, Yu Zhu, Walter Roper, Siyeon Rhee, Kevin Brulois, Ed O’Hara, Helena Kiefel, Truc M. Dinh, Yuhan Bi, Dalila Gonzalez, Evan P. Bao, Kristy Red-Horse, Peter Balogh, Fanni Gábris, Balázs Gaszner, Gergely Berta, Junliang Pan, Eugene C. Butcher   +21 more
doaj   +1 more source

NK-like homeodomain proteins activate NOTCH3-signaling in leukemic T-cells

BMC Cancer, 2009
Background Homeodomain proteins control fundamental cellular processes in development and in cancer if deregulated. Three members of the NK-like subfamily of homeobox genes (NKLs), TLX1, TLX3 and NKX2-5, are implicated in T-cell acute lymphoblastic ...
Drexler Hans G, Schmidt Christian A, Battmer Karin, Kaufmann Maren, Meyer Corinna, Grabarczyk Piotr, Przybylski Grzegorz K, Venturini Letizia, Nagel Stefan, Scherr Michaela, MacLeod Roderick AF   +10 more
doaj   +1 more source

HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis [PDF]

, 2018
Cytokinesis, the final phase of cell division, is necessary to form two distinct daughter cells with correct distribution of genomic and cytoplasmic materials.
A Konishi, A Verdina, AC Borisa, AT Lau, B Mierzwa, C Ditchfield, C Lazzari, C Mollinari, C Norden, C Rinaldo, C Rinaldo, C Rinaldo, C Rinaldo, Cinzia Rinaldo, CK Hu, D Valente, Davide Valente, E Gresko, F Siepi, G D’Orazi, G D’Orazi, G Normand, GE Atilla-Gokcumen, H Goto, HC Huang, I Vitale, JA Blaquiere, JM Cummins, JP Fededa, JR Bischoff, K Kobiyama, L Vega De la, Laura Monteonofrio, M Agromayor, M Carmena, M Glotzer, M Kollareddy, Manuela Ferrara, Marco Crescenzi, ME Douglas, ME Douglas, O Afonso, P Carpinelli, PP D’Avino, R Kuriyama, R Nunes Bastos, Roberta Miscione, S Francia, S Hauf, S Matt, Serena Camerini, Silvia Soddu, SM Lens, TD Pollard, TG Hofmann, TG Hofmann, V Bavetsias, VV Saul, VV Saul, WM Zhao, XL Li, Y Feng, Y Kuwano, Y Terada, YH Kim, Z Storchova   +65 more
core   +1 more source

Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development

eLife, 2018
The ancient mechanisms that caused developmental gene regulatory networks to diversify among distantly related taxa are not well understood. Here we use ancestral protein reconstruction, biochemical experiments, and developmental assays of transgenic ...
Qinwen Liu, Pinar Onal, Rhea R Datta, Julia M Rogers, Urs Schmidt-Ott, Martha L Bulyk, Stephen Small, Joseph W Thornton   +7 more
doaj   +1 more source

Molecular and cellular mechanisms of adipogenesis

Сахарный диабет, 2015
The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue.
Alexander Dmitrievich Egorov, Dmitry Nikolaevich Penkov, Vsevolod Arsen'evich Tkachuk   +2 more
doaj   +1 more source

Improving Hox protein classification across the major model organisms.

PLoS ONE, 2010
The family of Hox-proteins has been a major focus of research for over 30 years. Hox-proteins are crucial to the correct development of bilateral organisms, however, some uncertainty remains as to which Hox-proteins are functionally equivalent across ...
Stefanie D Hueber, Georg F Weiller, Michael A Djordjevic, Tancred Frickey   +3 more
doaj   +1 more source

Proximity labeling identifies a repertoire of site-specific R-loop modulators

Nature Communications, 2022
R-loops are three-stranded nucleic acid structures that contribute to genome instability and accumulate in neurological diseases. Here the authors identify R-loop proximal factors, which are enriched for zinc finger and homeodomain proteins, including ...
Qingqing Yan, Phillip Wulfridge, John Doherty, Jose L. Fernandez-Luna, Pedro J. Real, Hsin-Yao Tang, Kavitha Sarma   +6 more
doaj   +1 more source

The T-cell oncogenic protein HOX11 activates Aldh1 expression in NIH 3T3 cells but represses its expression in mouse spleen development [PDF]

, 1998
Hox11 is a homeobox gene essential for spleen formation in mice, since atrophy of the anlage of a developing spleen occurs in early embryonic development in Hox11 null mice.
Greene, W.K., Bahn, S., Masson, N., Rabbitts, T.H.   +3 more
core   +2 more sources

Functional Interaction of Jun and Homeodomain Proteins [PDF]

Journal of Biological Chemistry, 2001
We have used the yeast two-hybrid system to identify proteins that interact with the N-terminal region of c-Jun, which is known to be involved in regulatory interactions. One of the proteins identified is the homeodomain-containing protein Hex. The Hex homeodomain is sufficient for interaction; moreover, the homeodomains of several other transcription ...
L K, Schaefer, S, Wang, T S, Schaefer
openaire   +2 more sources