Results 81 to 90 of about 14,652 (219)

Emergence of hypervirulent and carbapenem-resistant Klebsiella pneumoniae ST37: genomic and phenotypic characterization of virulence and resistance

Frontiers in Microbiology
The emergence and spread of carbapenem-resistant Klebsiella pneumoniae (CRKP) ST37 necessitates urgent reassessment of its pathogenic potential. This study aims to characterize the genomic and phenotypic features of ST37 isolates collected from a ...
Li Shen, Weihua Han, Yu Huang, Shanshan Wang, Haojin Gao, Jinjin Yang, Jiana Fu, Zhixuan Chen, Junhong Shi, Xinru Yuan, Jingyi Yu, Fangyou Yu, Chunyang Wu   +12 more
doaj   +1 more source

Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids

Zoonoses and Public Health, Volume 73, Issue 6, Page 516-527, September 2026.
ABSTRACT Introduction Klebsiella pneumoniae is a pathogen associated with healthcare‐acquired infections and antimicrobial resistance (AMR) to beta‐lactams and carbapenems. Although wild animals are not typically exposed to antibiotics, they can harbour resistant strains. The European hedgehog (Erinaceus europaeus) is increasingly found in urban areas,
Biel Garcias, Chiara Seminati, Carolin M. Kobras, Samuel K. Sheppard, Rafael A. Molina‐López, Laila Darwich   +5 more
wiley   +1 more source

Immune modulations and survival strategies of evolved hypervirulent Salmonella Typhimurium strains

, 2020
Background Evolving multidrug-resistance and hypervirulence in Salmonella is due to multiple host-pathogen, and non-host environmental interactions. Previously we had studied Salmonella adaptation upon repeated exposure in different in-vitro and in-vivo
Negi, Vidya Devi, Mishra, Abtar, Pradhan, Diana, Chakravortty, Dipshikha, Diana Pradhan, Pradhan, Jasmin, Rohan Dhiman, Abtar Mishra, Dhiman, Rohan, Dipshikha Chakravortty, Karmakar, Kapudeep, Jasmin Pradhan, Kapudeep Karmakar, Vidya Devi Negi   +13 more
core   +1 more source

Genomic Epidemiology of Multidrug‐Resistant Clinical Klebsiella pneumoniae From Pakistan

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Study design and bioinformatics workflow. Cohort selection and uniform workflow. ABSTRACT Background Antimicrobial‐resistant Klebsiella pneumoniae is a major clinical threat in Pakistan and the wider South Asian region, where genomic surveillance remains limited. We analyzed 122 publicly available human clinical K.
Hakeem Zada, Muhammad Qasim, Mubashir Hussain, Abdul Rehman, Hassan Naveed, Noor Bahadar, Najibullah Anwari   +6 more
wiley   +1 more source

Genomic epidemiology of putative hypervirulent Klebsiella pneumoniae species complex in Dutch patients, January–December 2022

Microbiology Spectrum
Hypervirulent Klebsiella pneumoniae species complex (hvKp) can cause invasive infections with spontaneous abscesses, also in previously healthy individuals.
Karuna E. W. Vendrik, Gijs Teunis, Fardau Anema, Fabian Landman, Angela de Haan, Jeroen Bos, Sandra Witteveen, Annelot F. Schoffelen, Sabine C. de Greeff, Ed J. Kuijper, Antoni P. A. Hendrickx, Daan W. Notermans   +11 more
doaj   +1 more source

Longitudinal Molecular Epidemiology and Genomic Surveillance of Carbapenem‐Resistant Klebsiella pneumoniae in the Gut of Healthy Individuals in China

MedComm, Volume 7, Issue 8, August 2026.
Using 16,040 stool samples from healthy individuals across 30 Chinese provinces (2016–2024), we performed longitudinal genomic surveillance of carbapenem‑resistant Klebsiella pneumoniae (CRKP) colonizing the gut. We reveal rising community CRKP prevalence, especially in southern China, a shift from blaKPC‐2 to plasmid‑borne blaNDM‐5 on IncHI2/IncHI2A ...
Zelin Yan, Yan Li, Yi Sun, Qiaoling Sun, Congcong Liu, Yanyan Zhang, Yuchen Wu, Hongwei Zhou, Shangshang Qin, Gongxiang Chen, Ruichao Li, Rong Zhang   +11 more
wiley   +1 more source

Effects of the COVID-19 pandemic on clinical manifestations and therapeutic outcomes in acute endophthalmitis

Journal of Mind and Medical Sciences
Endophthalmitis incidence and clinical characteristics was reported to change during Covid-19 pandemic, due to multiple influencing factors, such as prolonged lockdown periods, persistent immune suppression following Sars-Cov-2 infection, and mask ...
Ana Maria Dascalu, Sanda Jurja, Carmen Luminita Mocanu, Cristina Alexandrescu, Daniela Stana, Madalina Totir, Ece Ergin, Corneliu Tudor, Catalin Cicerone Grigorescu, Dragos Serban, Laurentiu Simion, Dan Dumitrescu, Andrei Marin, Catalin Teodor Constantinescu, Bogdan Mihai Cristea   +14 more
doaj   +1 more source

Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains

Frontiers in Cellular and Infection Microbiology, 2018
Background: Development of improved therapeutics against tuberculosis (TB) is hindered by an inadequate understanding of the relationship between disease severity and genetic diversity of its causative agent, Mycobacterium tuberculosis.
Rahim Rajwani, Wing Cheong Yam, Ying Zhang, Yu Kang, Barry Kin Chung Wong, Kenneth Siu Sing Leung, Kingsley King Gee Tam, Ketema Tafess Tulu, Li Zhu, Gilman Kit Hang Siu   +9 more
doaj   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source

Emergence of a novel sequence type carbapenem-resistant hypervirulent Klebsiella pneumoniae ST6417 harboring blaNDM-5 on the lncX3 plasmid

Microbiology Spectrum
Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a significant pathogen causing major public health problems worldwide. This study characterized a novel sequence type 6417 (ST6471) CR-hvKP strain recovered from the blood of a male ...
Junnian Liu, Sue Yuan, Luhan Xuan, Yu Sun, Xinyu Zhang, Lu Qiao, Xuefei Du   +6 more
doaj   +1 more source