Results 51 to 60 of about 60,933,508 (232)

Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes

, 2018
Interleukin (IL)-30, the IL-27p28 subunit of the heterodimeric cytokine IL-27, acts as an antagonist of IL-27 and IL-6 signaling in murine cells via glycoprotein 130 (gp130) receptor and additional binding partners.
Yawen Yang, Nathalie Grandvaux, Carlene Petes, Mélissa K. Mariani, Katrina Gee   +4 more
core   +1 more source

Serum IL-27 levels increase in subjects with hypothyroidism and are negatively correlated with the occurrence of nonalcoholic fatty liver disease

Frontiers in Endocrinology, 2023
BackgroundThe level of serum interleukin-27 (IL-27) was significantly decreased in the obesity group. After injection of IL-27, obese mice showed significant weight loss,reduced fat accumulation, improved insulin resistance and hepatic steatosis.IL-27 ...
Yahui Wen, Heng Zhang, Ning Yang, Xia Gao, Zhe Chen, Jia Liu, Guang Wang   +6 more
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

The role of the cytokines IL-27 and IL-35 in cancer

, 2015
The cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer.
Avner Friedman and Kang-Ling Liao, Avner Friedman, Kang-Ling Liao   +2 more
core   +1 more source

Decreased serum levels of IL-27and IL-35 in patients with Graves disease

Archives of Endocrinology and Metabolism, 2020
Objectives Graves’ disease (GD) is an autoimmune disease causing the overproduction of the thyroid hormone from thyroid gland. This disease is mainly the result of the production of antibodies against TSH receptors.
Malek-Hosseini Saeed, Kalantar Kurosh, Amirghofran Zahra, Dabbaghmanesh Mohamad Hossein, Rostamzadeh Davood, Mohammad Reza Ataollahi   +5 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection.

, 2020
Inflammation is critical for controlling pathogens, but also responsible for symptoms of infectious diseases. IL-27 is an important regulator of inflammation and can limit development of IFNγ-producing Tbet+ CD4+ T (Th1) cells.
Edwards, Chelsea L, Uzonna, Jude E, Frame, Teija CM, Ng, Susanna S, Wang, Yulin, Kabat, Agnieszka, Kuns, Rachel D, Winterford, Clay, de Labastida Rivera, Fabian, Engwerda, Christian R, Amante, Fiona H, Montes de Oca, Marcela, Zhang, Ping, et al., Bukali, Luzia, Chelsea L Edwards, Clay Winterford, Chelsea L. Edwards, Geoffrey R. Hill, Luzia Bukali, Yulin Wang, Geoffrey R Hill, Rachel D Kuns, Edward J. Pearce, Ping Zhang, Rachel D. Kuns, Marcela Montes de Oca, Jude E Uzonna, Susanna S Ng, Teija C. M. Frame, Fiona H. Amante, Ramon I. Klein Geltink, Fiona H Amante, Jude E. Uzonna, Susanna S. Ng, Christian R. Engwerda, Edward J Pearce, Agnieszka Kabat, Teija C M Frame, Ramon I Klein Geltink, Christian R Engwerda, Fabian de Labastida Rivera   +41 more
core   +1 more source

The interleukin-27 -964A>G polymorphism enhances sepsis-induced inflammatory responses and confers susceptibility to the development of sepsis

Critical Care, 2018
Background Previous studies have identified critical roles of IL-27 in the pathological mechanisms of sepsis, and blockade of IL-27 may be a promising alternative therapy for sepsis.
Junbing He, Quanfu Zhang, Wenying Zhang, Feng Chen, Tian Zhao, Yao Lin, Jia Li, Yansong Liu, Yuchun Liu, Yiming Shao   +9 more
doaj   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source