Results 91 to 100 of about 5,255,854 (171)

Graph attention network enables multipurpose prediction of imaging mass cytometry in a hepatocellular carcinoma clinical trial

Intelligent Oncology
Imaging mass cytometry (IMC) enables the high-resolution spatial profiling of tumor microenvironment, but its clinical utility for prospective prediction remains underdeveloped.
Hang Shi, Wei Shao, Jinyuan Song, Gang Che, Yaxing Zhao, Yangyang Shi, Junlei Zhang, Peng Wan, Qi Zhu, Daoqiang Zhang, Jianpeng Sheng   +10 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Multiplex imaging analysis of the tumor immune microenvironment for guiding precision immunotherapy

Frontiers in Immunology
Cutting-edge multiplex imaging technologies have significantly advanced our understanding of the tumor immune microenvironment (TIME), delivering nanometer-scale spatial resolution that illuminates previously inaccessible cellular interactions and ...
Feng Liu, Feng Liu, Feng Liu, Guiqing Li, Guiqing Li, Yi Zheng, Yi Zheng, Yanxia Liu, Yanxia Liu, Kang Liu, Kang Liu   +10 more
doaj   +1 more source

Computational immune synapse analysis reveals T-cell interactions in distinct tumor microenvironments

Communications Biology
The tumor microenvironment (TME) and the cellular interactions within it can be critical to tumor progression and treatment response. Although technologies to generate multiplex images of the TME are advancing, the many ways in which TME imaging data can
Victor G. Wang, Zichao Liu, Jan Martinek, Ali Foroughi pour, Jie Zhou, Hannah Boruchov, Kelly Ray, Karolina Palucka, Jeffrey H. Chuang   +8 more
doaj   +1 more source

Characterization and spatial distribution of infiltrating lymphocytes in medullary, and lymphocyte-predominant triple negative breast cancers

npj Breast Cancer
Medullary carcinoma of the breast (MedBC) is a rare histological type that accounts for less than 5% of all invasive breast cancers. Here, we performed an exploratory study aimed to determine whether imaging mass cytometry (IMC) can be used to ...
A. Alfaro, C. Catelain, H. El-Masri, P. Rameau, M. Lacroix-Triki, JY. Scoazec, V. Marty, F. Mosele, B. Pistilli   +8 more
doaj   +1 more source

A proteotranscriptomic approach to dissect the molecular landscape of human retinoblastoma

Frontiers in Oncology
BackgroundRetinoblastoma is a rare pediatric eye cancer caused by mutations in the RB1 gene, which regulates retinal cell growth. Early detection and treatment are critical for preventing vision loss and improving survival outcomes.
Julian Wolf, Rozina Ida Hajdu, Stefaniya Boneva, Ira Godbole, Lucas Stürzbecher, Claudia Auw-Haedrich, Wolf A. Lagrèze, Hansjürgen Agostini, Thomas Reinhard, Stefan Tholen, Oliver Schilling, Günther Schlunck, Bertram Bengsch, Clemens Lange   +13 more
doaj   +1 more source

Biodistribution of nanoplastics in mice: advancing analytical techniques using metal-doped plastics

Communications Biology
Contamination of plastic particles in environmental and biological systems raises concerns regarding their potential negative impacts. Human exposure to microplastics (MPs) and nanoplastics (NPs) is increasing; however, some potential adverse health ...
Theresa Staufer, Verena Kopatz, Alice Pradel, Tess Brodie, Robert Kuhrwahl, Deborah Stroka, Julia Wallner, Lukas Kenner, Verena Pichler, Florian Grüner, Denise M. Mitrano   +10 more
doaj   +1 more source

The single-cell landscape of triple-negative breast cancer reveals a prognostic role of progenitor-like basoluminal tumor cells (IMC data)

<p>This repository contains all <strong>raw imaging mass cytometry (IMC) data</strong> for the triple negative breast cancer IMC study from Meyer et al., 2024. The code that was used to process and analyze the data is available at https:
Meyer, Lasse
core   +1 more source

Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer [PDF]

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. PDAC is characterized by a complex tumor microenvironment (TME), that plays a pivotal role in disease progression and resistance to therapy.
Elena Magrini, Raffaella D’Anna, Federica Marchesi, Marco Erreni, Giorgia Tiberi, Damiano Zanini, Raffaella Parente, Paola Cappello, Ermes Candiello, Maria Rita Fumagalli, Andrea Doni, Candiello, E., Fumagalli, M. R., Cappello, P., D'Anna, R., Tiberi, G.   +15 more
core   +1 more source

Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response

Metabolites
A multimodal mass spectrometry imaging (MSI) approach was used to investigate the chemotherapy drug-induced response of a Multicellular Tumour Spheroid (MCTS) 3D cell culture model of osteosarcoma (OS). The work addresses the critical demand for enhanced
Sophie M. Pearce, Neil A. Cross, David P. Smith, Malcolm R. Clench, Lucy E. Flint, Gregory Hamm, Richard Goodwin, James I. Langridge, Emmanuelle Claude, Laura M. Cole   +9 more
doaj   +1 more source