Results 71 to 80 of about 5,255,854 (171)

Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver

JCI Insight, 2021
Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structural ...
Daniel Traum, Yue J. Wang, Kathleen B. Schwarz, Jonathan Schug, David K.H. Wong, Harry L.A. Janssen, Norah A. Terrault, Mandana Khalili, Abdus S. Wahed, Karen F. Murray, Phillip Rosenthal, Simon C. Ling, Norberto Rodriguez-Baez, Richard K. Sterling, Daryl T.Y. Lau, Timothy M. Block, Michael D. Feldman, Elizabeth E. Furth, William M. Lee, David E. Kleiner, Anna S. Lok, Klaus H. Kaestner, Kyong-Mi Chang   +22 more
doaj   +1 more source

Role of Tertiary Lymphoid Structures in Autoimmune Diseases and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Schematic overview of tertiary lymphoid structures (TLSs): The development process, detection, and the immune function that depends on the environment in different disease contexts of TLS. TLSs originate from loose lymphoid aggregates that acquire ordered follicular architecture to become primary follicular‐like TLS, before maturing into ...
Ze Yan, Bin Wen, Ying Hu, Xiaocui Wang, Xuemei Duan, Haonan Li, Shumin Dong, Yufeng Fan, Caihong Wang, Shutong Yang, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

Imaging mass cytometry data from breast cancer patient derived xenografts

, 2021
Imaging mass cytometry data from breast cancer patient derived ...
Maurizio Callari
core   +1 more source

Imaging Mass Cytometric Analysis of Postmortem Tissues Reveals Dysregulated Immune Cell and Cytokine Responses in Multiple Organs of COVID-19 Patients

Frontiers in Microbiology, 2020
SARS-coronavirus-2–induced immune dysregulation and inflammatory responses are involved in the pathogenesis of coronavirus disease-2019 (COVID-19). However, very little is known about immune cell and cytokine alterations in specific organs of COVID-19 ...
Chong Wang, Chong Wang, Jiqian Xu, Shaoyuan Wang, Shangwen Pan, Jiancheng Zhang, Yang Han, Yang Han, Yang Han, Muhan Huang, Muhan Huang, Di Wu, Di Wu, Qingyu Yang, Xiaobo Yang, Yang Yang, Ting Shu, Ting Shu, Xiaojing Zou, Ruiting Li, Yufeng Luo, Runqing Yao, Yaxin Wang, Yang Qiu, Yang Qiu, Yu Wang, Ding-Yu Zhang, Qun Yao, Yongpan Yan, Xi Zhou, Xi Zhou, Xi Zhou, You Shang, You Shang, You Shang   +34 more
doaj   +1 more source

A multiplex tissue resource for high‐resolution spatial protein profiling in the Human Protein Atlas

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Spatially resolved protein expression is essential for understanding tissue organization, cellular specialization, and protein function. The open‐access Human Protein Atlas database (www.proteinatlas.org) has generated an extensive antibody‐based tissue resource for a majority of the human protein‐coding genes using conventional ...
Borbala Katona, Rutger Schutten, Filippa Bertilsson, Feria Hikmet, Per Adelsköld, Mattias Forsberg, Kalle von Feilitzen, Loren Méar, Mathias Uhlén, Cecilia Lindskog   +9 more
wiley   +1 more source

Metal-Labeled Aptamers as Novel Nanoprobes for Imaging Mass Cytometry Analysis

, 2020
Imaging mass cytometry (IMC) is an emerging imaging technology that exploits the multiplexed analysis capabilities of the CyTOF mass cytometer to make spatially resolved measurements for tissue sections.
Xiao Liu (65413), Ting Zhang (102583), Jingqi Dang (8649138), Xianting Ding (4985153), Youyi Yu (1795558), Liping Wang (33601), Shanhe Li (7906595)   +6 more
core   +1 more source

Method to investigate the distribution of water-soluble drug-delivery systems in fresh frozen tissues using imaging mass cytometry

, 2021
Imaging mass cytometry (IMC) offers the opportunity to image metal- and heavy halogen-containing xenobiotics in a highly multiplexed experiment with other immunochemistry-based reagents to distinguish uptake into different tissue structures or cell types.
Rose, Jonathan, Race, Alan M., Barry, Simon T., Ling, Stephanie, Strittmatter, Nicole, Moss, Jennifer I., Sutton, Daniel, England, Richard M., Maglennon, Gareth, Wong, Edmond, Macdonald, Ruth, Purvis, Ian, Ashford, Marianne B., Goodwin, Richard J.A., Edmond Wong, Simon T. Barry, Richard M. England, Stephanie Ling, Nicole Strittmatter, Jennifer I. Moss, Alan M. Race, Jonathan Rose, Marianne B. Ashford, Ian Purvis, Richard J. A. Goodwin, Daniel Sutton, Gareth Maglennon, Ruth Macdonald   +27 more
core   +1 more source

3D‐Printed Milli‐Fluidic Mixing‐Extrusion Platform for Continuous, High‐Throughput LNP Production

Small, Volume 22, Issue 48, 26 August 2026.
We report a continuous high‐throughput production of lipid nanoparticles (LNPs) by integrating a reusable 3D‐printed milli‐fluidic split‐and‐recombine mixer with inline membrane extrusion. The 3D architecture enables rapid early‐stage mixing, reducing clogging and fouling, while inline extrusion further refines the as‐formed LNPs, improving uniformity,
Leekang Jeon, Seeun Kim, Hanjin Seo, Hyun Su Lee, Gi‐Su Na, Gi‐Ra Yi, Hyomin Lee   +6 more
wiley   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Multi-modal image analysis for large-scale cancer tissue studies within IMMUcan

Cell Reports: Methods
Summary: In cancer research, multiplexed imaging allows detailed characterization of the tumor microenvironment (TME) and its link to patient prognosis. The integrated immunoprofiling of large adaptive cancer patient cohorts (IMMUcan) consortium collects
Nils Eling, Julien Dorier, Sylvie Rusakiewicz, Robin Liechti, Preethi Devanand, Michelle Daniel, Jonas Windhager, Bruno Palau Fernandez, Sophie Déglise, Lucie Despland, Abdelkader Benyagoub, Marcin Możejko, Dawid Uchal, Ewa Szczurek, Alexander Loboda, Daaf Sandkuijl, Nikesh Parsotam, Henoch S. Hong, Marie Morfouace, Nicolas Guex, George Coukos, Bernd Bodenmiller, Stephanie Tissot, Daniel Schulz   +23 more
doaj   +1 more source