Results 61 to 70 of about 4,996,457 (177)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Aerosolized miR-138-5p and miR-200c targets PD-L1 for lung cancer prevention

Frontiers in Immunology, 2023
The development of chemopreventive strategies with the ability to prevent the progression of lung lesions to malignant cancers would reduce the mortality and morbidity resulting from this deadly disease.
Qi Zhang, Jing Pan, Donghai Xiong, Junjun Zheng, Kristi N. McPherson, Sangbeom Lee, Mofei Huang, Yitian Xu, Shu-hsia Chen, Yian Wang, Lea Hildebrandt Ruiz, Ming You   +11 more
doaj   +1 more source

Imaging Mass Cytometry (IMC) as a Tool to Characterize Circulating Tumor Cells (CTCs) in Preclinical Mouse Models

Abstract Circulating tumor cells (CTCs), particularly multicellular clusters, are associated with poor prognosis and may provide insight into mechanisms of metastasis and therapy resistance. Unbiased approaches for functionally characterizing CTCs in liquid biopsies are therefore urgently needed. Here, we evaluate multiplex imaging mass
Milind Pore, Kuppusamy Balamurugan, Abigail Atkinson, Devynn Breen, Paul Mallory, Ashley Cardamone, Lois McKennett, Christine Newkirk, Shikha Sharan, William Bocik, Esta Sterneck   +10 more
openaire   +3 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, Volume 13, Issue 35, 24 June 2026.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Secondary Ion Mass Spectrometry Imaging of Dictyostelium discoideum Aggregation Streams [PDF]

, 2014
High resolution imaging mass spectrometry could become a valuable tool for cell and developmental biology, but both, high spatial and mass spectral resolution are needed to enable this.
Pa��a-Toli��, Ljiljana, Smith, D.F. (Donald), Heeren, Ron M. A., Francisco A. Fern, Richard H. Gomer (214653), Richard H. Gomer, Paša-Tolić, Ljiljana, Heeren, Ron M.A., Christopher R Anderton, Gomer, R.H., Ron M A Heeren, Fernandez-Lima, Francisco A., Francisco A Fernandez-Lima, John Daniel DeBord (575199), Heeren, R.M.A. (Ron), John Daniel DeBord, Donald F Smith, Francisco A. Fernandez-Lima (575202), Fernandez-Lima, F., Smith, Donald F., Fernandez-Lima, Francisco, DeBord, John Daniel, Donald F. Smith (575200), Ljiljana Paša-Tolić, Donald F. Smith, Ron M. A. Heeren, Anderton, C.R., Ron M. A. Heeren (213370), Christopher R. Anderton, Christopher R. Anderton (575201), Ljiljana Paša-Tolić (2449252), DeBord, J.D., Richard H Gomer, Gomer, Richard H., Anderton, Christopher R., Williams, Jeffrey Graham   +35 more
core   +2 more sources

PD-L1+CD8+ T cells enrichment in lung cancer exerted regulatory function and tumor-promoting tolerance

iScience, 2022
Summary: Immunotherapy targeting checkpoint blockade to rescue T cells from exhaustion has become an essential therapeutic strategy in treating cancers. Till now, little is known about the PD-L1 graphic pattern and characteristics in CD8+ T cells.
Yingxia Zheng, Li Han, Zheyi Chen, Yiyang Li, Bingqian Zhou, Rui Hu, Shiyu Chen, Haibo Xiao, Yanhui Ma, Guohua Xie, Junyao Yang, Xianting Ding, Lisong Shen   +12 more
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Dry Deposition Strategies for MALDI–MS Imaging: Principles, Advances and Emerging Applications

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI–MSI) has become a pivotal tool in biomedical research, enabling untargeted, spatially resolved analysis of molecular species in complex biological tissues. Among the critical steps in MALDI–MSI workflows, matrix deposition significantly influences sensitivity, spatial
Toufik Mahamdi, Oscar Yanes
wiley   +1 more source

Integrative Clustering in Mass Spectrometry Imaging for Enhanced Patient Stratification [PDF]

, 2019
Scope In biomedical research, mass spectrometry imaging (MSI) can obtain spatially-resolved molecular information from tissue sections. Especially matrix-assisted laser desorption/ionization (MALDI) MSI offers, depending on the type of matrix, the ...
Martin-Lorenzo, Marta, McDonnell, L.A., Heeren, Ron M. A., Heeren, R.M.A., Walch, Axel, Martin-Lorenzo, M., Dewez, F., Heeren, Ron M.A., Buck, Achim, Buck, A., Walch, A.K., Balluff, B., Langer, R., Dewez, Frédéric, Balluff, Benjamin, Langer, Rupert, McDonnell, Liam A.   +16 more
core   +2 more sources

Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver

JCI Insight, 2021
Studies of human hepatitis B virus (HBV) immune pathogenesis are hampered by limited access to liver tissues and technologies for detailed analyses. Here, utilizing imaging mass cytometry (IMC) to simultaneously detect 30 immune, viral, and structural ...
Daniel Traum, Yue J. Wang, Kathleen B. Schwarz, Jonathan Schug, David K.H. Wong, Harry L.A. Janssen, Norah A. Terrault, Mandana Khalili, Abdus S. Wahed, Karen F. Murray, Phillip Rosenthal, Simon C. Ling, Norberto Rodriguez-Baez, Richard K. Sterling, Daryl T.Y. Lau, Timothy M. Block, Michael D. Feldman, Elizabeth E. Furth, William M. Lee, David E. Kleiner, Anna S. Lok, Klaus H. Kaestner, Kyong-Mi Chang   +22 more
doaj   +1 more source