Results 51 to 60 of about 4,996,457 (177)

MALDI mass spectrometry imaging in rheumatic diseases [PDF]

, 2017
Mass spectrometry imaging (MSI) is a technique used to visualize the spatial distribution of biomolecules such as peptides, proteins, lipids or other organic compounds by their molecular masses.
Ruiz-Romero, Cristina, Cillero-Pastor, Berta, Blanco, Francisco J., Rocha, Beatriz   +3 more
core   +2 more sources

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Automated, parallel mass spectrometry imaging and structural identification of lipids [PDF]

, 2018
We report a method that enables automated data-dependent acquisition of lipid tandem mass spectrometry data in parallel with a high-resolution mass spectrometry imaging experiment.
Mark W. Jervelund, Heeren, Ron M. A., Peter Husen, Ejsing, Christer S.; id_orcid, Eijkel, Gert B., Josch K. Pauling, Hermansson, Martin, Jervelund, Mark W., Heeren, Ron M.A., Ron M. A. Heeren, Shane R. Ellis, Martin Hermansson, Martin R. L. Paine, Ellis, Shane R., Christer S. Ejsing, Ejsing, Christer S., Paine, Martin R.L., Husen, Peter, Gert B. Eijkel, Paine, Martin R. L., Pauling, Josch K.   +20 more
core   +2 more sources

Fibroblast Activation Protein Expression Differs Between Inflamed and Fibrostenotic Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
This study demonstrates that fibroblast activation protein expression is elevated in inflamed and fibrostenotic inflammatory bowel disease, with highest levels in fibrostenotic Crohn's disease. Cellular fibroblast activation protein predominates in inflamed tissues and localises to α‐SMA−PDPN−CD90+ stromal cells. ABSTRACT Background Intestinal fibrosis
Dalia A. Lartey, Bram W. van Os, Bo Jun Ke, Kelly van Wijnbergen, Gert de Hertogh, Luuk J. A. C. Hawinkels, Gianluca Matteoli, Jie Su, Christianne J. Buskens, Jarmilla D. W. van der Bilt, Geert R. A. M. D'Haens, Joep Grootjans, Manon E. Wildenberg, Marieke C. Barnhoorn, Mark Löwenberg   +14 more
wiley   +1 more source

Coupling imaging mass cytometry with Alcian blue histochemical staining for a single-slide approach

Frontiers in Immunology
Imaging mass cytometry (IMC) is a metal mass spectrometry-based method allowing highly multiplex immunophenotyping of cells within tissue samples. However, some limitations of IMC are its 1-µm resolution and its time and costs of analysis limiting ...
Patrice Hemon, Danivanh Ben-Guigui, Margaux Geier, Margaux Geier, Marine Castillon, Marine Castillon, Corentin Paranthoen, Corentin Paranthoen, Jacques-Olivier Pers, Marion Le Rochais, Arnaud Uguen, Arnaud Uguen   +11 more
doaj   +1 more source

A multiplex tissue resource for high‐resolution spatial protein profiling in the Human Protein Atlas

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Spatially resolved protein expression is essential for understanding tissue organization, cellular specialization, and protein function. The open‐access Human Protein Atlas database (www.proteinatlas.org) has generated an extensive antibody‐based tissue resource for a majority of the human protein‐coding genes using conventional ...
Borbala Katona, Rutger Schutten, Filippa Bertilsson, Feria Hikmet, Per Adelsköld, Mattias Forsberg, Kalle von Feilitzen, Loren Méar, Mathias Uhlén, Cecilia Lindskog   +9 more
wiley   +1 more source

A Multimodal SIMS/MALDI Mass Spectrometry Imaging Source with Secondary Electron Imaging Capabilities for Use with timsTOF Instruments

, 2023
Mass spectrometry imaging (MSI) is a surface analysis technique that produces chemical images and is commonly used for biological and biomedical research.
Sebastian Böhm (14765814), Ian G. M. Anthony (5810702), Heeren, R.M.A., Kasper Krijnen (14765811), Hohndorf, J., Keelor, J.D., Anthony, I.G.M., Krijnen, K., Ron M. A. Heeren (7181636), Joel D. Keelor (1898416), Bohm, S., Koster, C., Shane R. Ellis (1862107), Claus Köster (14765817), Jens Höhndorf (8947847), Ellis, S.R.   +15 more
core   +1 more source

Characterization of papillary and clear cell renal cell carcinoma through imaging mass cytometry reveals distinct immunologic profiles

Frontiers in Immunology, 2023
ObjectiveTo characterize and further compare the immune cell populations of the tumor microenvironment (TME) in both clear cell and papillary renal cell carcinoma (RCC) using heavy metal-labeled antibodies in a multiplexed imaging approach (imaging mass ...
Ameish Govindarajan, Nicholas J. Salgia, Nicholas J. Salgia, Nicholas J. Salgia, Haiqing Li, Daniela V. Castro, Tamara Mirzapoiazova, Brian Armstrong, Dan Zhao, Dan Zhao, Benjamin D. Mercier, Nazli Dizman, Nazli Dizman, Neal Chawla, Zeynep Zengin, Luis Meza, Nishita Tripathi, Nicolas Sayegh, Alex Chehrazi-Raffle, Abhishek Tripathi, Sumanta K. Pal   +20 more
doaj   +1 more source

Mass Spectrometry Imaging of Microbes

, 2020
Microbes influence many aspects of human life from the environment to health, yet evaluating their biological processes at the chemical level can be problematic. Mass spectrometry imaging (MSI) enables direct evaluation of microbial chemical processes at
Yang, Hyojik, Ernst, Robert K., Goodlett, David R., Scott, Alison J.   +3 more
core   +1 more source

3D‐Printed Milli‐Fluidic Mixing‐Extrusion Platform for Continuous, High‐Throughput LNP Production

Small, Volume 22, Issue 48, 26 August 2026.
We report a continuous high‐throughput production of lipid nanoparticles (LNPs) by integrating a reusable 3D‐printed milli‐fluidic split‐and‐recombine mixer with inline membrane extrusion. The 3D architecture enables rapid early‐stage mixing, reducing clogging and fouling, while inline extrusion further refines the as‐formed LNPs, improving uniformity,
Leekang Jeon, Seeun Kim, Hanjin Seo, Hyun Su Lee, Gi‐Su Na, Gi‐Ra Yi, Hyomin Lee   +6 more
wiley   +1 more source