Results 101 to 110 of about 2,892 (197)

Efficient diastereoselective synthesis of a new class of azanucleosides : 2'-homoazanucleosides [PDF]

, 2017
Bouton, Jakob, Van Calenbergh, Serge, Van Hecke, Kristof   +2 more
core   +2 more sources

Synthesis and evaluation of hepatitis C antivirals : viral E2 glycoprotein / human CD81 receptor interaction inhibitors [PDF]

, 2008
The aim of the present work was to prepare compounds which inhibit the CD81-LEL—HCV-E2 interaction by binding to CD81-LEL. Starting point was a virtual screening using the open conformation of the LEL followed by synthesis and biological validation by ...
Holzer, Marcel
core  

Investigation of the enantioselectivity of acetylcholinesterase and butyrylcholinesterase upon inhibition by tacrine-iminosugar heterodimers. [PDF]

J Enzyme Inhib Med Chem, 2023
Vaaland IC, López Ó, Puerta A, Fernandes MX, Padrón JM, Fernández-Bolaños JG, Sydnes MO, Lindbäck E.   +7 more
europepmc   +1 more source

Total asymmetric syntheses of iminosugars

, 2016
This thesis is concerned with the development of ring-closing iodoamination and ringexpansion methodology and its subsequent application to the asymmetric syntheses of pyrrolidine and piperidine iminosugars. Chapter 1 highlights the remarkable biological properties displayed by iminosugars and introduces methods for the formation of the pyrrolidine and
Figuccia, A, Figuccia, Aude
openaire   +1 more source

C-(2-Deoxy-D-arabino-hex-1-enopyranosyl)-oxadiazoles: synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors [PDF]

, 2021
Bokor, Éva, Csupász, Tibor, Docsa, Tibor, Gergely, Pál, Somsák, László, Szennyes, Eszter, Tóth, Nóra   +6 more
core   +1 more source

Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial

Clinical Interventions in Aging, 2018
Robert J Nash,1 Boris KG Azantsa,2 Hazel Sharp,1 Velmurugan Shanmugham31PhytoQuest Limited, Plas Gogerddan, Aberystwyth, Ceredigion, UK; 2Department of Biochemistry, University of Yaoundé I, Yaoundé, Cameroon; 3Samrat Research Institute ...
Nash RJ, Azantsa BKG, Sharp H, Shanmugham V   +3 more
doaj  

<i>N</i>-Substitution effects on the conformations of iminosugar analogues of 1-deoxy-l-idose and 1-deoxy-l-iduronic acid. [PDF]

RSC Adv
Taglietti L, Palomba E, Lange H, Zoia L, Chiacchio MA, Legnani L, La Ferla B.   +6 more
europepmc   +1 more source

Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases. [PDF]

ACS Cent Sci, 2023
Swanson CRB, Ford GJ, Mattey AP, Gourbeyre L, Flitsch SL.   +4 more
europepmc   +1 more source

Exploring Small-Molecule Inhibitors of Glucosidase II: Advances, Challenges, and Therapeutic Potential in Cancer and Viral Infection. [PDF]

Int J Mol Sci
Oo TZM, Wuttiin Y, Choocheep K, Kumsaiyai W, Bunpo P, Cressey R.   +5 more
europepmc   +1 more source

Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases. [PDF]

Chem Sci, 2023
van der Gracht D, Rowland RJ, Roig-Zamboni V, Ferraz MJ, Louwerse M, Geurink PP, Aerts JMFG, Sulzenbacher G, Davies GJ, Overkleeft HS, Artola M.   +10 more
europepmc   +1 more source