Results 101 to 110 of about 114,851,153 (292)

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Antioxidant and Hypoglycemic Activities of Perilla Leaves in Vitro

Shipin gongye ke-ji
In order to study the antioxidant and hypoglycemic activities in vitro of Perilla leaves and their extracts, the starch paste samples with Perilla leaves were prepared using a rapid viscosity analyzer, and then in vitro simulated gastrointestinal ...
Yanqiao ZHAO, Shaoping WANG, Yue WANG, Bing SUN, Jianying LI   +4 more
doaj   +1 more source

Omnidirectional Interaction Networks Modulating Phenotypic Plasticity in the Gut Microbiota Towards Ulcerative Colitis

Advanced Science, EarlyView.
This study employs a spouse‐pair cohort design and an idopNetwork model that integrates evolutionary game theory, predator‐prey dynamics, and developmental modularity theory to reconstruct maximally informative microbial interaction networks. This approach reveals how interspecies interactions drive the phenotypic plasticity of the gut microbiota in ...
Huizhen Li, Jiayi Li, Ang Dong, Xiaoyan Guo, Qiuyue Tu, Zelin Feng, Haojia Lin, Yanru Zhang, Yuxuan Hao, Huiying Gong, Yihan Meng, Yu Wang, Shing‐Tung Yau, Xiaocang Cao, Rongling Wu, Xinjuan Liu   +15 more
wiley   +1 more source

Oil palm fiber extract as a fermentable functional ingredient: in vitro gastrointestinal carbohydrate hydrolysis, feline fecal fermentation, and microbiota-associated metabolite production

Frontiers in Food Science and Technology
Obesity-associated gastrointestinal disturbances in companion animals have increased interest in dietary ingredients that may modulate intestinal fermentation and microbial metabolism.
Kristina Dea Ivanalie, Uchenna Kalu Akpi, Yada Duangnumsawang, Chutha Takahashi Yupanqui, Santad Wichienchot   +4 more
doaj   +1 more source

Cooking does not impair the impact of pulsed electric field on the protein digestion of venison (Cervus elaphus) during in vitro gastrointestinal digestion

, 2020
The present study was conducted to elucidate whether cooking impairs the positive effect of pulsed electric field (PEF) on the digestibility of venison during in vitro gastrointestinal protein digestion.
Morton, James, Mungure, T, Bhat, ZF, Mason, SL, Jayawardena, SR, Bekhit, AEDA   +5 more
core   +1 more source

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Chlorophyll Inhibits the Digestion of Soybean Oil in Simulated Human Gastrointestinal System

, 2022
Nowadays, much available processed and highly palatable food such as cream products and fried and convenient food, which usually showed a high energy density, had caused an increase in the intake of dietary lipids, further leading to significant growth ...
Yang, Zhaotian, Suxia Shen, Zhang, Haifeng, Zhaotian Yang, Li, Yuanyuan, Xiao Wang, Haifeng Zhang, Yan Zhang, Zhang, Yan, Wang, Xiao, Shen, Suxia, Yuanyuan Li   +11 more
core   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Advancing Biotherapeutic Treatment of Ulcerative Colitis Using Lipid Mesophases: Formulation Design and Preclinical Validation

Advanced Science, EarlyView.
Lipid mesophases provide a versatile platform for colon‐targeted delivery of biotherapeutics, protecting them from degradation while enhancing mucoadhesion and enabling localized, controlled release to the inflamed mucosa after oral or rectal administration. In a DSS‐induced colitis model, this strategy reduced disease activity, inflammatory biomarkers,
Rafaela Gazzi, Tiziana Cremona, Reto Czekalla, Emily Campbell, Marlene Schwarzfischer, Doris Pöhlmann, Vanessa Dobernig, Gerhard Rogler, Michael Scharl, Alessandra Bergadano, Raffaele Mezzenga, Martin Kuentz, Paola Luciani, Simone Aleandri   +13 more
wiley   +1 more source

Release of nutrients and exorphins during in vitro static gastrointestinal digestion of spaghetti from durum wheat

, 2014
Consumption of wheat-derived products has been linked with significant nutritional and health impacts such as the management of glycaemic index and the onset of immunological reactions.
A. Marti, V. Micard, S. Cattaneo, A. Ferraretto, P. De Luca, M.A. Pagani, I. De Noni, M. Stuknyte   +7 more
core   +2 more sources