Results 11 to 20 of about 2,197 (174)

VirBR, a transcription regulator, promotes IncX3 plasmid transmission, and persistence of bla NDM-5 in zoonotic bacteria [PDF]

Nature Communications
IncX3 plasmids carrying the New Delhi metallo-β-lactamase-encoding gene, bla NDM-5, are rapidly spreading globally in both humans and animals. Given that carbapenems are listed on the WHO AWaRe watch group and are prohibited for use in animals, the ...
Tengfei Ma, Ning Xie, Yuan Gao, Jiani Fu, Chun E. Tan, Qiu E. Yang, Shaolin Wang, Zhangqi Shen, Quanjiang Ji, Julian Parkhill, Congming Wu, Yang Wang, Timothy R. Walsh, Jianzhong Shen   +13 more
doaj   +13 more sources

Fitness Cost of bla_NDM-5-Carrying p3R-IncX3 Plasmids in Wild-Type NDM-Free Enterobacteriaceae [PDF]

Microorganisms, 2020
The wide dissemination of New Delhi metallo-β-lactamase genes (blaNDM) has resulted in the treatment failure of most available β-lactam antibiotics, with IncX3-type blaNDM-5-carrying plasmids recognised as having spread worldwide.
Tengfei Ma, Jiani Fu, Ning Xie, Shizhen Ma, Lei Lei, Weishuai Zhai, Yingbo Shen, Chengtao Sun, Shaolin Wang, Zhangqi Shen, Yang Wang, Timothy R. Walsh, Jianzhong Shen   +12 more
doaj   +4 more sources

Occurrence of Highly Conjugative IncX3 Epidemic Plasmid Carrying blaNDM in Enterobacteriaceae Isolates in Geographically Widespread Areas [PDF]

Frontiers in Microbiology, 2018
The emergence of New Delhi metallo-β-lactamase (NDM) in common enterobacterial species is a major concern for healthcare. Early reports have revealed that the spread of NDM involved diverse and heterogeneous plasmids. Recently, the involvement of a rare,
Ya Wang, Man-Ki Tong, Kin-Hung Chow, Vincent Chi-Chung Cheng, Cindy Wing-Sze Tse, Alan Ka-Lun Wu, Raymond Wai-Man Lai, Wei-Kwang Luk, Dominic Ngai-Chong Tsang, Pak-Leung Ho   +9 more
doaj   +5 more sources

IncX3 Plasmid-Mediated Spread of blaNDM Gene in Enterobacteriaceae Among Children in China

Journal of Global Antimicrobial Resistance
: Objectives: The blaNDM gene was prevalent among children and became the predominant cause of severe infection in infants and children. This study aimed to investigate the epidemiology and molecular characteristics of blaNDM in Enterobacteriaceae among
Chuanqing Wang, Pan Fu, Qin Jie
exaly   +5 more sources

IncX3 plasmid mediated occurrence of blaNDM-4 within Escherichia coli ST448 from India

Journal of Infection and Public Health, 2018
This study was designed to investigate blaNDM-4 encoded within IncX3 type plasmid and their copy number alteration under carbapenem pressure within clinical isolates of Escherichia coli. NDM-4 producing E.
Nargis A. Choudhury, Deepjyoti Paul, Atanu Chakravarty, Amitabha Bhattacharjee, Debadatta Dhar Chanda   +4 more
doaj   +4 more sources

In silico characterization of IncX3 plasmids carrying blaOXA-181 in Enterobacterales

Frontiers in Cellular and Infection Microbiology, 2022
Carbapenem-resistant Enterobacterales poses a global urgent antibiotic resistance threat because of its ability to transfer carbapenemase genes to other bacteria via horizontal gene transfer mediated by mobile genetic elements such as plasmids ...
Zhijian Yu, Zhengrong Zhang, Lile Shi, Shengni Hua, Ting Luan, Qiuping Lin, Zhixiong Zheng, Xiaosan Feng, Mubiao Liu, Xiaobin Li   +9 more
doaj   +3 more sources

Characterization of a Novel Sequence Type (ST) 6758 Klebsiella Pneumoniae and the Role of IncX3 Plasmid in the Transmission of blaNDM [PDF]

Infection and Drug Resistance
Yawen Zhang,* Qiao Li,* Lirong Li, Hao Guo, Fang He Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People ...
Zhang Y, Li Q, Li L, Guo H, He F
doaj   +4 more sources

Genomic and functional characterisation of IncX3 plasmids encoding blaSHV-12 in Escherichia coli from human and animal origin [PDF]

Scientific Reports, 2018
The blaSHV-12 β-lactamase gene is one of the most prevalent genes conferring resistance to extended-spectrum β-lactams in Enterobacteriaceae disseminating within and between reservoirs, mostly via plasmid-mediated horizontal gene transfer.
Jonathan Betts, Bossers, A., Michael S. M. Brouwer, Betts, J., Apostolos Liakopoulos, Smith, H., Dik Mevius, Jeanet van der Goot, Alex Bossers, Hilde Smith, Liakopoulos, A., Goot, J. van der, Ceccarelli, D., Mevius, D., Brouwer, M.S.M., Arie Kant, Daniela Ceccarelli, Kant, A.   +17 more
core   +8 more sources

Molecular Characterization of an Atypical IncX3 Plasmid pKPC-NY79 Carrying blaKPC-2 in a Klebsiella pneumoniae [PDF]

Current Microbiology, 2013
The IncX family of plasmids has recently been expanded to include at least four subtypes, IncX1-IncX4. The revised classification provides an opportunity for improving our understanding of the sequence diversity of the IncX plasmids and the resistance ...
Cheng, VCC, CHEUNG, YY, Lo, WU, Lin, C, Chan, JFW, LI, Z, Ho, PL, Chow, KH   +7 more
core   +6 more sources

Further Spread of blaNDM-5 in Enterobacteriaceae via IncX3 Plasmids in Shanghai, China [PDF]

Frontiers in Microbiology, 2016
One hundred and two carbapenem-resistant Enterobacteriaceae (CRE) strains were isolated in a teaching hospital in Shanghai, China from 2012 to 2015. In a follow-up study, 4 New Delhi metallo-β-lactamase-5 (NDM-5)-producing strains were identified after ...
Xiaoli Wang, Hongping eQu, Fangfang Zhang, Jingyong Sun, Lianyan eXie, Xiaokui Guo, Jingyong eSun, Lizhong Han, Lizhong eHan, Xiaokui eGuo, Fangfang eZhang, Lianyan Xie, Xiaoli eWang, Yuxing eNi, Hongping Qu, Yuxing Ni   +15 more
core   +5 more sources