Results 21 to 30 of about 2,386 (192)

Genomic Characterization of Carbapenemase-Producing Klebsiella pneumoniae ST895 Isolates from Canine Origins Through Whole-Genome Sequencing Analysis [PDF]

Microorganisms
The widespread application of carbapenems and other broad-spectrum antibiotics has significantly escalated the threat posed by highly drug-resistant Klebsiella pneumoniae to human public health.
Ronglei Huang, Wei Gao, Yue Sun, Yan Ye, Tingting Luo, Yitong Pan, Chengyang Zhang, Ang Zhou, Wenzhi Ren, Chongtao Du   +9 more
doaj   +2 more sources

Rectal Carriage of Sequence Type 307 Klebsiella pneumoniae High-Risk Clone Harboring Multiple Carbapenemase Genes in Community Hospitals Gauteng, South Africa. [PDF]

Microbiologyopen
Graphical presentation of rectal carriage of carbapenem‐resistant Klebsiella pneumoniae, highlighting ST307 high‐risk clone and IncX3 plasmid‐associated blaOXA‐181. This study highlights the threat linked to horizontal gene transfer of AMR genes by epidemic plasmids from Klebsiella pneumoniae high‐risk clones to other bacterial species.
Salvador-Oke KT, Pitout J, Peirano G, Strydom KA, Kingsburgh C, Ehlers M, Kock M.   +6 more
europepmc   +2 more sources

Characterization of the IncX3 Plasmid Producing blaNDM–7 From Klebsiella pneumoniae ST34 [PDF]

Frontiers in Microbiology, 2020
Carbapenemase-producing Klebsiella pneumoniae has been a major clinical threat worldwide because therapeutic options are limited. Although New Delhi metallo-β-lactamase (NDM) is an important carbapenemase responsible for carbapenem resistance, it is uncommon in carbapenemase-producing K. pneumoniae in China. In this study, we described strain HZW25, an
Qiong Chen, Jiawei Zhou, Shenghai Wu, Yunxing Yang, Daojun Yu, Xianjun Wang, Min Wu   +6 more
openaire   +3 more sources

Emergence of a High-Risk Klebsiella michiganensis Clone Disseminating Carbapenemase Genes

Frontiers in Microbiology, 2022
Klebsiella michiganensis is emerging as an important human pathogen of concern especially strains with plasmid-mediated carbapenemase genes. The IncX3-blaNDM-5 plasmid has been described as the primary vector for blaNDM-5 dissemination.
Isaac Prah, Isaac Prah, Yoko Nukui, Yoko Nukui, Shoji Yamaoka, Ryoichi Saito, Ryoichi Saito   +6 more
doaj   +1 more source

VirBR counter-silences HppX3 to promote conjugation of blaNDM-IncX3 plasmids. [PDF]

Nucleic Acids Res
Abstract New Delhi metallo-β-lactamases (NDM), encoded by the blaNDM gene, mediate carbapenem resistance, posing serious threats to public health due to their global presence across diverse hosts and environments. The blaNDM is prominently carried by the IncX3 plasmid, which encodes a Type IV secretion system (T4SS) responsible for ...
Gao Y, Xie N, Ma T, Tan CE, Wang Z, Zhang R, Ma S, Deng Z, Wang Y, Shen J.   +9 more
europepmc   +3 more sources

Genetic and phenotypic characterizations of IncX3 plasmids harboring bla NDM-5 and bla NDM-16b in Japan

Microbiology Spectrum, 2023
The spread of the gene encoding the NDM-type carbapenemase, bla NDM, poses a serious threat to clinical practice and public health. This gene is usually carried by transferable plasmids, which facilitates its rapid spread among various species of ...
Hui Zuo, Yo Sugawara, Shizuo Kayama, Sayoko Kawakami, Koji Yahara, Motoyuki Sugai   +5 more
doaj   +1 more source

Dissemination and Stability of the bla_NDM-5-Carrying IncX3-Type Plasmid among Multiclonal Klebsiella pneumoniae Isolates

mSphere, 2020
NDM-5 carbapenemase was mainly identified in Escherichia coli, while the rapid transmission of blaNDM-5 among Enterobacteriaceae has raised serious public attention.
Wenjun Zhu, Xing Wang, Juanxiu Qin, Wei Liang, Zhen Shen   +4 more
doaj   +1 more source

Adaptive Evolution Compensated for the Plasmid Fitness Costs Brought by Specific Genetic Conflicts

Pathogens, 2023
New Delhi metallo-β-lactamase (NDM)-carrying IncX3 plasmids is important in the transmission of carbapenem resistance in Escherichia coli. Fitness costs related to plasmid carriage are expected to limit gene exchange; however, the causes of these fitness
Feifeng Li, Jiong Wang, Ying Jiang, Yingyi Guo, Ningjing Liu, Shunian Xiao, Likang Yao, Jiahui Li, Chuyue Zhuo, Nanhao He, Baomo Liu, Chao Zhuo   +11 more
doaj   +1 more source

Insights into a Novel blaKPC-2-Encoding IncP-6 Plasmid Reveal Carbapenem-Resistance Circulation in Several Enterobacteriaceae Species from Wastewater and a Hospital Source in Spain [PDF]

, 2017
Untreated wastewater, particularly from hospitals and other healthcare facilities, is considered to be a reservoir for multidrug-resistant bacteria.
Cantón, Rafael, Chakraborty, Trinad, Dominguez, Lucas, Falgenhauer, Linda, Imirzalioglu, Can, Lazaro-Perona, Fernando, Mingorance, Jesús, Valverde, Aránzazu, Yao, Yancheng   +8 more
core   +1 more source

Co‐localization of clinically relevant antibiotic‐ and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves

MicrobiologyOpen, Volume 12, Issue 4, August 2023., 2023
Klebsiella pneumoniae is an opportunistic pathogen frequently associated with antibiotic resistance and present in a wide range of environments. In this study, five antibiotic‐resistant K. pneumoniae isolates recovered from bivalves, of which four also carried heavy metal resistance genes, were selected for complete genome sequencing.
Fredrik Håkonsholm, Marit A. K. Hetland, Iren H. Löhr, Bjørn Tore Lunestad, Nachiket P. Marathe   +4 more
wiley   +1 more source