Frontiers in Immunology, 2023 IntroductionThe mechanisms underlying innate immune memory (trained immunity) comprise epigenetic reprogramming of transcriptional pathways associated with alterations of intracellular metabolism.
Emmanuel Chaumond +8 more
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Innate Immune Cells Speak Manganese [PDF]
Immunity, 2018 Some metal ions, such as Ca2+ and Zn2+, are involved in intracellular communication in immune cells by acting as second messengers. In this issue of Immunity, Wang et al. (2018) present findings implying a similar role for an additional metal ion, by showing that manganese participates in the recognition of cytoplasmic DNA.
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Targeting Innate Immune Cells for Immunotherapy [PDF]
Journal of Immunology Research, 2017 Referencia
Leandro J. Carreño +4 more
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Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes [PDF]
, 2017 BACKGROUND: Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, suggesting dysregulation of the ...
Dreyfus, David H. +12 more
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Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]
, 2019 Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong +14 more
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In Vivo Zymosan Treatment Induces IL15-Secreting Macrophages and KLRG1-Expressing NK Cells in Mice
Molecules, 2023 Beta-glucan (β-glucan) is a natural polysaccharide produced by fungi, bacteria, and plants. Although it has been reported that β-glucan enhances innate immune memory responses, it is unclear whether different types of β-glucans display similar immune ...
Hyun Jung Park +7 more
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Be aware, innate immune cells remember [PDF]
Aging, 2018 Contains fulltext : 199946.pdf (Publisher’s version ) (Open Access)
Riksen, N.P., Netea, M.G., Netea, M.G.
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Potential role of gut microbiota in induction and regulation of innate immune memory [PDF]
, 2019 The gut microbiota significantly regulates the development and function of the innate and adaptive immune system. The attribute of immunological memory has long been linked only with adaptive immunity.
Agrewala, Javed N +4 more
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Vascular Endothelial Cells and Innate Immunity [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2020 In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively participate in both innate and adaptive immune responses. We previously reported that, in comparison to macrophages, a prototypic innate immune cell type, ECs have many innate immune functions that macrophages carry out, including cytokine ...
Ying Shao +11 more
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Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
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