Results 41 to 50 of about 154,668 (248)

Heme induces innate immune memory [PDF]

, 2019
ABSTRACTTrained immunity defines long-lasting adaptive responses of innate immunity, mediated by transcriptional and epigenetic modifications of myeloid cells. Here, we report that labile heme, an alarmin released extracellularily upon tissue damage and hemolysis, induces trained immunity in human and murine primary cells and in mice. Heme-trainning in
Jentho, Elisa, Novakovic, Boris, Ruiz-Moreno, Cristian, Kourtzelis, Ioannis, Martins, Rui, Chavakis, Triantafyllos, Soares, Miguel Perreira, Kalafati, Lydia, Guerra, Joel, Roestel, Franziska, Bohm, Peter, Godmann, Maren, Grinenko, Tatyana, Eugster, Anne, Beretta, Martina, Joosten, Leo A.B., Netea, Mihai G., Stunnenberg, Hendrik G., Bauer, Michael, Weis, Sebastian   +19 more
openaire   +1 more source

Planarians SET New Paths for Innate Immune Memory [PDF]

EBioMedicine, 2017
Contains fulltext : 174794.pdf (Publisher’s version ) (Open Access)
Keating, S.T., Riksen, N.P., Netea, M.G., Netea, M.G.   +3 more
openaire   +4 more sources

Transcriptomics and quantitative proteomics reveal changes after second stimulation of bone marrow-derived macrophages from lupus-prone MRL/lpr mice

Frontiers in Immunology, 2022
Innate immune memory can cause the occurrence and exacerbation of autoimmune diseases, and it is as well as being strongly associated with the pathogenesis of systemic lupus erythematosus (SLE), however, the specific mechanism remains to be further ...
Keyue Chen, Tiyun Wu, Danyan Wang, Rong Li, Xiangfeng Shen, Ting Zhao, Keiko Ozato, Rongqun Li   +7 more
doaj   +1 more source

Trained Immunity and Local Innate Immune Memory in the Lung [PDF]

Cell, 2018
Trained innate immunity mediates protection against heterologous infections and is mediated by epigenetic and functional reprogramming of myeloid cells and their progenitors. Now, Yao et al. describe trained immunity induced locally in alveolar macrophages by a viral infection, with IFNγ release from effector CD8+ lymphocytes initiating this process.
Netea, M.G., Netea, M.G., Joosten, L.A.B., Joosten, L.A.B.   +3 more
openaire   +3 more sources

Induction of Innate Immune Memory by Engineered Nanoparticles: A Hypothesis That May Become True

Frontiers in Immunology, 2017
Innate immune memory is the capacity of cells of the innate immune system, such as monocytes and macrophages, to react differently to an inflammatory or infectious challenge if previously exposed to the same or to another agent. Innate immune memory is a
Paola Italiani, Diana Boraschi
doaj   +1 more source

Stroma: the forgotten cells of innate immune memory [PDF]

Clinical and Experimental Immunology, 2018
SummaryAll organisms are exposed constantly to a variety of infectious and injurious stimuli. These induce inflammatory responses tailored to the threat posed. While the innate immune system is the front line of response to each stimulant, it has been considered traditionally to lack memory, acting in a generic fashion until the adaptive immune arm can
Crowley, T, Buckley, C, Clark, A
openaire   +3 more sources

A Shift from Cellular to Humoral Responses Contributes to Innate Immune Memory in the Vector Snail Biomphalaria glabrata.

PLoS Pathogens, 2016
Discoveries made over the past ten years have provided evidence that invertebrate antiparasitic responses may be primed in a sustainable manner, leading to the failure of a secondary encounter with the same pathogen.
Silvain Pinaud, Julien Portela, David Duval, Fanny C Nowacki, Marie-Aude Olive, Jean-François Allienne, Richard Galinier, Nolwenn M Dheilly, Sylvie Kieffer-Jaquinod, Guillaume Mitta, André Théron, Benjamin Gourbal   +11 more
doaj   +1 more source

Advances in immune response to pulmonary infection: Nonspecificity, specificity and memory

Chronic Diseases and Translational Medicine, 2023
The lung immune response consists of various cells involved in both innate and adaptive immune processes. Innate immunity participates in immune resistance in a nonspecific manner, whereas adaptive immunity effectively eliminates pathogens through ...
Jianqiao Xu, Lixin Xie
doaj   +1 more source

BCG-induced protection: Effects on innate immune memory [PDF]

Seminars in Immunology, 2014
The Bacille Calmette-Guerin (BCG) vaccine is the only vaccine proved to be effective against tuberculosis and it remains the most commonly used vaccine worldwide. In addition to its effects on mycobacterial diseases, an increasing body of epidemiological evidence accumulated since its introduction in 1921 shows that BCG also exerts beneficial non ...
Netea, M.G., Crevel, R. van
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source