Results 1 to 10 of about 10,873 (167)

Interferon Lambda Signaling Restrains Experimental Autoimmune Encephalomyelitis [PDF]

Biomedicines
IFN-λ is a type III interferon (IFN) with pleiotropic functions in modulating immune responses. To address its function in autoimmune neuroinflammation, we evaluated the development and progression of experimental autoimmune encephalitis (EAE) in IFNLR1 ...
Mohammad Asif Sherwani, Samuel J. Duesman, Zdenek Hel, Chander Raman, Nabiha Yusuf   +4 more
doaj   +4 more sources

Interferon Lambda in the Pathogenesis of Inflammatory Bowel Diseases [PDF]

Frontiers in Immunology, 2021
Interferon λ (IFN-λ) is critical for host viral defense at mucosal surfaces and stimulates immunomodulatory signals, acting on epithelial cells and few other cell types due to restricted IFN-λ receptor expression. Epithelial cells of the intestine play a
Jonathan W. Wallace, David A. Constant, Timothy J. Nice   +2 more
doaj   +5 more sources

Interferon Lambda Signaling in Macrophages Is Necessary for the Antiviral Response to Influenza [PDF]

Frontiers in Immunology, 2021
Interferon lambda (IFNλ) signaling is a promising therapeutic target against viral infection in murine models, yet little is known about its molecular regulation and its cognate receptor, interferon lambda receptor 1 (IFNLR1) in human lung.
Rama K. Mallampalli, Jessica Adair, Ajit Elhance, Daniela Farkas, Lexie Chafin, Matthew E. Long, Matthew E. Long, Mithu De, Ana L. Mora, Mauricio Rojas, Victor Peters, Joseph S. Bednash, MuChun Tsai, James D. Londino   +13 more
doaj   +4 more sources

Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling [PDF]

Viruses, 2023
Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). Multiple IFNLR1 transcriptional variants are expressed in
John Grayson Evans, Laura A. Novotny, Eric G. Meissner   +2 more
doaj   +4 more sources

Interferon Lambda: The Next Frontier in Antiviral Therapy? [PDF]

Pharmaceuticals
Type III interferons (IFN-λ) are the most recently identified members of the interferon family, distantly related to type I interferons and members of the interleukin-10 (IL-10).
Sofia Chronopoulou, Ilias Tsochantaridis
doaj   +2 more sources

Interferon Lambda Delays the Emergence of Influenza Virus Resistance to Oseltamivir [PDF]

Microorganisms, 2021
Influenza viruses are a leading cause of morbidity and mortality worldwide. These air-borne pathogens are able to cross the species barrier, leading to regular seasonal epidemics and sporadic pandemics.
Chiara Medaglia, Arnaud Charles-Antoine Zwygart, Paulo Jacob Silva, Samuel Constant, Song Huang, Francesco Stellacci, Caroline Tapparel   +6 more
doaj   +2 more sources

Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice [PDF]

Virus Research
Recent studies indicate that treatment of chronic hepatitis D virus (HDV) with either pegylated interferon (IFN)λ or pegylated IFNα monotherapy leads to a dramatic decline in HDV RNA. Herein, we investigated the innate antiviral efficacy of IFNλ and IFNα
Sarah Duehren, Takuro Uchida, Masataka Tsuge, Nobuhiko Hiraga, Susan L. Uprichard, Ohad Etzion, Jeffrey Glenn, Christopher Koh, Theo Heller, Scott J. Cotler, Shiro Oka, Kazuaki Chayama, Harel Dahari   +12 more
doaj   +2 more sources

Homeostatic pockets of interferon lambda-stimulated gene production in the intestine are associated with localized exposure to bacterial microbiota [PDF]

Gut Microbes
Tolerance of enteric microbiota and clearance of potential pathogens is critical for gut homeostasis. We previously found that the healthy small intestine of mice contains discrete pockets of antiviral gene expression that depend on bacterial microbiota ...
David A. Constant, Jacob A. Van Winkle, Kimberly A. Meyer, Shelby R. Madden, Bryan Ramirez Reyes, Timothy J. Nice   +5 more
doaj   +2 more sources

Homeostatic antiviral protection of the neonatal gut epithelium by interferon lambda [PDF]

Cell Reports
Summary: Cell-intrinsic antiviral gene expression by intestinal epithelial cells (IECs) limits infection by enteric viral pathogens. Here, we find that neonatal IECs express antiviral genes at homeostasis that depend on interferon lambda (IFN-λ) and are ...
Bryan Ramirez Reyes, Shelby Madden, Kimberly A. Meyer, Brenden Bartsch, Austin P. Wright, David A. Constant, Timothy J. Nice   +6 more
doaj   +2 more sources

Association of Interferon Lambda 3 and 4 Gene SNPs and Their Expression with COVID-19 Disease Severity: A Cross-Sectional Study [PDF]

Infection and Drug Resistance, 2023
Warisha Zahid,1,* Nida Farooqui,2,* Nida Zahid,3,* Khalid Ahmed,2 Muhammad Faraz Anwar,4 Syed Rizwan-ul-Hasan,5 Azhar R Hussain,2 Antonio Sarría-Santamera,6 Syed Hani Abidi2,6 1Department of Community Health Sciences, Aga Khan University ...
Zahid W, Farooqui N, Zahid N, Ahmed K, Anwar MF, Rizwan-ul-Hasan S, Hussain AR, Sarría-Santamera A, Abidi SH   +8 more
doaj   +2 more sources