Results 11 to 20 of about 10,873 (167)

Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium [PDF]

Frontiers in Immunology
Type III interferon (IFN-λ), a new member of the IFN family, was initially considered to possess antiviral functions similar to those of type I interferon, both of which are induced via the JAK/STAT pathway.
Yong-Guang Liu, Su-Wei Jin, Shan-Shan Zhang, Tian-Ji Xia, Yong-Hong Liao, Rui-Le Pan, Ming-Zhu Yan, Qi Chang   +7 more
doaj   +4 more sources

Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections [PDF]

Frontiers in Immunology, 2017
Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and ...
Sanghyun Lee, Megan T. Baldridge
doaj   +6 more sources

Interferons lambda – therapeutic application [PDF]

Сибирский научный медицинский журнал, 2020
Interferons are a group of protein molecules with a broad spectrum of effects on the human body. Interferon lambda (type III interferon) was discovered comparatively recently about 20 years ago and its action is still poorly understood.
N. A. Kikhtenko, L. A. Oleynik, V. K. Makarov, E. P. Nagorskaya, P. G. Madonov   +4 more
doaj   +2 more sources

Early Treatment with Pegylated Interferon Lambda for Covid-19. [PDF]

N Engl J Med, 2023
The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear.We conducted a randomized, controlled, adaptive platform trial involving predominantly vaccinated adults with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Reis G, Moreira Silva EAS, Medeiros Silva DC, Thabane L, Campos VHS, Ferreira TS, Santos CVQ, Nogueira AMR, Almeida APFG, Savassi LCM, Figueiredo-Neto AD, Dias ACF, Freire Júnior AM, Bitarães C, Milagres AC, Callegari ED, Simplicio MIC, Ribeiro LB, Oliveira R, Harari O, Wilson LA, Forrest JI, Ruton H, Sprague S, McKay P, Guo CM, Limbrick-Oldfield EH, Kanters S, Guyatt GH, Rayner CR, Kandel C, Biondi MJ, Kozak R, Hansen B, Zahoor MA, Arora P, Hislop C, Choong I, Feld JJ, Mills EJ, Glenn JS, TOGETHER Investigators.   +41 more
europepmc   +6 more sources

Lambda Interferons: New Cytokines with Old Functions [PDF]

Pharmaceuticals, 2010
Interferon lambda (IFN-λ) is a member of the class II cytokine family, and like the other members of this family, they are small helical proteins. Since their discovery significant efforts have been made to determine their role in innate and adaptive ...
Ole J. Hamming, Hans Henrik Gad, Søren Paludan, Rune Hartmann   +3 more
doaj   +3 more sources

Macrophage Coordination of the Interferon Lambda Immune Response [PDF]

Frontiers in Immunology, 2019
Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral diseases.
Scott A. Read, Scott A. Read, Ratna Wijaya, Mehdi Ramezani-Moghadam, Enoch Tay, Steve Schibeci, Christopher Liddle, Vincent W. T. Lam, Vincent W. T. Lam, Lawrence Yuen, Lawrence Yuen, Mark W. Douglas, Mark W. Douglas, David Booth, Jacob George, Golo Ahlenstiel, Golo Ahlenstiel, Golo Ahlenstiel   +17 more
doaj   +4 more sources

COVID‐19: lambda interferon against viral load and hyperinflammation [PDF]

EMBO Molecular Medicine, 2020
Coronavirus disease 2019 (COVID‐19), triggered by the betacoronavirus SARS‐CoV‐2, has become one of the worst pandemics of our time that has already caused more than 250,000 deaths (JHU data‐05/06/2020, https://coronavirus.jhu.edu/ ).
Evangelos Andreakos, Sotirios Tsiodras
doaj   +4 more sources

Interferon Lambda: Modulating Immunity in Infectious Diseases [PDF]

Frontiers in Immunology, 2017
Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade.
Syedbasha, Mohammedyaseen, Egli, Adrian
openaire   +4 more sources

Interferon Lambda: A New Sword in Cancer Immunotherapy [PDF]

Clinical and Developmental Immunology, 2011
The discovery of the interferon-lambda (IFN-λ) family has considerably contributed to our understanding of the role of interferon not only in viral infections but also in cancer. IFN-λ proteins belong to the new type III IFN group.
Ahmed Lasfar, Walid Abushahba, Murugabaskar Balan, Karine A. Cohen-Solal   +3 more
doaj   +3 more sources

Interferons and systemic sclerosis: correlation between interferon gamma and interferon-lambda 1 (IL-29)

Autoimmunity, 2015
Interferon (IFN)-λ1 is a newly described cytokine, member of type III interferons family, which is known for its antiviral, anti-proliferative and antitumor activity. Recent studies indicated that this cytokine has also immune-regulatory function, but its role in the pathogenesis of autoimmune diseases is not established yet.
Andréa Tavares, Dantas, Sayonara Maria Calado, Gonçalves, Michelly Cristiny, Pereira, Anderson Rodrigues, de Almeida, Cláudia Diniz Lopes, Marques, Moacyr Jesus Barreto de Melo, Rego, Ivan da Rocha, Pitta, Angela Luzia Branco Pinto, Duarte, Maira Galdino da Rocha, Pitta   +8 more
openaire   +4 more sources