Results 21 to 30 of about 10,873 (167)
Pegylated Interferon Lambda for Covid-19
New England Journal of Medicine, 2023 Mingqiang, Wang +2 more
openaire +6 more sources
Interferon lambda restricts herpes simplex virus skin disease by suppressing neutrophil-mediated pathology [PDF]
mBioType III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ against skin infections have not been extensively investigated. We sought
Drake T. Philip +6 more
doaj +2 more sources
Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections. [PDF]
J Interferon Cytokine Res, 2023 Johnson D, Carbonetti N.
europepmc +2 more sources
Different Mechanisms Are Utilized by Coronavirus Transmissible Gastroenteritis Virus To Regulate Interferon Lambda 1 and Interferon Lambda 3 Production. [PDF]
J Virol, 2022 Coronaviruses cause infectious diseases in various mammals and birds and exhibit an epithelial cell tropism in enteric and respiratory tracts. It is critical to explore how coronavirus infections modulate IFN-λ, a key innate cytokine against mucosal viral infection.
Xue M +7 more
europepmc +3 more sources
Interferon lambda 4 is a gut antimicrobial protein. [PDF]
Proc Natl Acad Sci U S ATo withstand complex microbial challenges, the mammalian gut largely depends on the secretion of diverse antimicrobial proteins. Type III interferons (IFNλs) are ordinarily considered inducible antiviral cytokines involved in intestinal immunity. Unlike other IFNλs, we found that newly identified IFNλ4 is an intestinal antibacterial protein.
Xiao X +9 more
europepmc +3 more sources
Сибирский научный медицинский журнал, 2021 The aim of the study was to determine the efficacy of recombinant human interferon lambda 1 (IFN-λ1) against human adenovirus serotype 5 in a culture of human conjunctival cells Chang conjunctiva clone 1-5c-4. Material and methods.
N. A. Kikhtenko +4 more
doaj +1 more source
Interferon lambda in inflammation and autoimmune rheumatic diseases. [PDF]
Nat Rev Rheumatol, 2021 Interferons are potent antiviral cytokines that modulate immunity in response to infection or other danger signals. In addition to their antiviral functions, type I interferons (IFNα and IFNβ) are important in the pathogenesis of autoimmune diseases.
Goel RR, Kotenko SV, Kaplan MJ.
europepmc +4 more sources
Interferon lambdas: the next cytokine storm [PDF]
Gut, 2011 For two decades the scientific community has sought to understand why some people clear hepatitis C virus (HCV) and others do not. Recently, several large genome-wide association studies have identified single nucleotide polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the spontaneous resolution and successful ...
Kelly, C, Klenerman, P, Barnes, E
openaire +5 more sources
Functional Characterization of Canine Interferon-Lambda [PDF]
Journal of Interferon & Cytokine Research, 2014 In this study, we provide the first comprehensive annotation of canine interferon-λ (CaIFN-λ, type III IFN). Phylogenetic analysis based on genomic sequences indicated that CaIFN-λ is located in the same branch with Swine IFN-λ1 (SwIFN-λ), Bat IFN-λ1 (BaIFN-λ), and human IFN-λ1 (HuIFN-λ1). CaIFN-λ was cloned, expressed in Escherichia coli, and purified
Wenhui, Fan +8 more
openaire +2 more sources
Virology Journal, 2021 Background The recent pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has elevated several clinical and scientific questions.
Pooneh Rahimi +8 more
doaj +1 more source