Results 31 to 40 of about 10,873 (167)
Frontiers in Immunology, 2021 Interferon lambdas (IFNλ) (also known as type III IFNs) are critical cytokines that combat infection predominantly at barrier tissues, such as the lung, liver, and gastrointestinal tract. Humans have four IFNλs (1–4), where IFNλ1–3 show ~80%–95% homology,
Cuncai Guo +11 more
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Antiviral Activity of Lambda Interferon in Chickens [PDF]
Journal of Virology, 2014 ABSTRACTInterferons (IFNs) are essential components of the antiviral defense system of vertebrates. In mammals, functional receptors for type III IFN (lambda interferon [IFN-λ]) are found mainly on epithelial cells, and IFN-λ was demonstrated to play a crucial role in limiting viral infections of mucosal surfaces.
Reuter, Antje +7 more
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An anti-influenza combined therapy assessed by single cell RNA-sequencing
Communications Biology, 2022 When combined with interferon lambda, virucidal sialylated cyclodextrins inhibit the replication of a clinical H1N1 influenza strain in ex vivo human airway epithelia more efficiently than when delivered alone.
Chiara Medaglia +10 more
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Treatment with Ad5-Porcine Interferon-α Attenuates Ebolavirus Disease in Pigs
Pathogens, 2022 Under experimental conditions, pigs infected with Ebola Virus (EBOV) develop disease and can readily transmit the virus to non-human primates or pigs. In the event of accidental or intentional EBOV infection of domestic pigs, complex and time-consuming ...
Chandrika Senthilkumaran +10 more
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Expression and function of interferon lambda receptor 1 variants. [PDF]
FEBS LettLambda interferons (IFNLs) provide critical host defense against pathogens encountered at mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell‐type restricted expression of the lambda interferon receptor 1 protein with expression restricted primarily to epithelial cells located at mucosal surfaces.
Novotny LA, Meissner EG.
europepmc +3 more sources
mSphere of Influence: Interferon Ultra Is a Means To Fight Viral Disease
mSphere, 2020 Connor G. G. Bamford works in the fields of virology and innate immunity. In this mSphere of Influence article, he reflects on how three papers by Manry et al. (J. Manry, G. Laval, E. Patin, S.
Connor G. G. Bamford
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PLoS ONE, 2016 BackgroundHepatitis C virus infection is a global health problem. New direct-acting antiviral agents have been recently approved. However, due to their high cost and some genotypes remaining difficult to treat, interferon-based therapy with pegylated ...
Ran Chen +4 more
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Interferon Lambda Inhibits Bacterial Uptake during Influenza Superinfection [PDF]
Infection and Immunity, 2019 Influenza kills 30,000 to 40,000 people each year in the United States and causes 10 times as many hospitalizations. A common complication of influenza is bacterial superinfection, which exacerbates morbidity and mortality from the viral illness.
Helen E, Rich +6 more
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Interferon induction by the immunomodulating polyanion lambda carrageenan [PDF]
Infection and Immunity, 1979 The lambda fraction of carrageenan induced murine interferon, which was characterized by sensitivity to trypsin and inhibition by pretreatment of target cells with actinomycin D.
E V, Turner, G, Sonnenfeld
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Journal of Inflammation Research, 2021 Scott A Read,1– 3 Brian S Gloss,4 Christopher Liddle,3 Jacob George,3 Golo Ahlenstiel1– 3 1Blacktown Clinical School, Western Sydney University, Blacktown, NSW, 2148, Australia; 2Blacktown Hospital, WSLHD, Blacktown, NSW, 2148, Australia ...
Read SA +4 more
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