Results 31 to 40 of about 176,830 (333)
GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions.
Journal of Clinical Investigation, 2019 A single sub-anesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders.
Danielle M. Gerhard +11 more
semanticscholar +1 more source
Journal of Neuroscience, 2020 Parvalbumin-expressing (PV+) interneurons play a key role in the maturation and synchronization of cortical circuitry and alterations in these inhibitory neurons, especially in the medial prefrontal cortex (mPFC), have been found in different psychiatric
H. Carceller +4 more
semanticscholar +1 more source
STDP-driven networks and the \emph{C. elegans} neuronal network [PDF]
, 2010 We study the dynamics of the structure of a formal neural network wherein the strengths of the synapses are governed by spike-timing-dependent plasticity (STDP). For properly chosen input signals, there exists a steady state with a residual network.
Jost, Jürgen +3 more
core +2 more sources
Developmental diversification of cortical inhibitory interneurons
Nature, 2017 Diverse subsets of cortical interneurons have vital roles in higher-order brain functions. To investigate how this diversity is generated, here we used single-cell RNA sequencing to profile the transcriptomes of mouse cells collected along a ...
Christian Mayer +9 more
semanticscholar +1 more source
GABAergic interneurons excite neonatal hippocampus in vivo
Science Advances, 2020 During development, the brain’s “inhibitory” neurons act in a diverse manner, exciting hippocampus but inhibiting sensory cortex. GABAergic interneurons are proposed to be critical for early activity and synapse formation by directly exciting, rather ...
Yasunobu Murata, M. Colonnese
semanticscholar +1 more source
Molecular Psychiatry, 2020 Major depressive disorder (MDD) is associated with alterations of GABAergic interneurons, notably somatostatin (Sst) as well as parvalbumin (Pvalb), in cortical brain areas.
M. Fogaça +5 more
semanticscholar +1 more source
Dedicated hippocampal inhibitory networks for locomotion and immobility [PDF]
, 2017 Network activity is strongly tied to animal movement; however, hippocampal circuits selectively engaged during locomotion or immobility remain poorly characterized.
Arriaga, Moises, Han, Edward B
core +2 more sources
Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia
Frontiers in Behavioral Neuroscience, 2019 Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive
Alexei M. Bygrave +6 more
doaj +1 more source
Prefrontal somatostatin interneurons encode fear memory
bioRxiv, 2019 Theories stipulate that memories are encoded within networks of cortical projection neurons. Conversely, GABAergic interneurons are thought to function primarily to inhibit projection neurons and thereby impose network gain control, an important but ...
Kirstie A. Cummings, Roger L. Clem
semanticscholar +1 more source
Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions
Frontiers in Physiology, 2018 Systematic research on the physiological and anatomical characteristics of spinal cord interneurons along with their functional output has evolved for more than one century.
Marie-Pascale Côté +4 more
doaj +1 more source