Results 41 to 50 of about 176,830 (333)

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice

Frontiers in Cell and Developmental Biology, 2020
Neural stem cells in the lateral ganglionic eminence (LGE) generate progenitors that migrate through the rostral migratory stream (RMS) to repopulate olfactory bulb (OB) interneurons, but the regulation of this process is poorly defined.
Christopher A. Blackwood, Christopher A. Blackwood, Christopher A. Blackwood, Alessandro Bailetti, Sayan Nandi, Thomas Gridley, Jean M. Hébert   +6 more
doaj   +1 more source

Cell-type-specific synaptic modulation of mAChR on SST and PV interneurons

Frontiers in Psychiatry, 2023
The muscarinic acetylcholine receptor (mAChR) antagonist, scopolamine, has been shown to have a rapid antidepressant effect. And it is believed that GABAergic interneurons play a crucial role in this action.
Huanxin Chen, Huanxin Chen, Ting He, Meiyi Li, Chunlian Wang, Chen Guo, Wei Wang, Wei Wang, Baocong Yu, Jintao Huang, Lijun Cui, Ping Guo, Yonggui Yuan, Tao Tan, Tao Tan   +14 more
doaj   +1 more source

Cortical gamma band synchronization through somatostatin interneurons

Nature Neuroscience, 2017
Gamma band rhythms may synchronize distributed cell assemblies to facilitate information transfer within and across brain areas, yet their underlying mechanisms remain hotly debated.
Julia Veit, Richard Hakim, Monika P. Jadi, T. Sejnowski, H. Adesnik   +4 more
semanticscholar   +1 more source

Time Windows of Interneuron Development: Implications to Our Understanding of the Aetiology and Treatment of Schizophrenia

AIMS Neuroscience, 2015
Schizophrenia is a devastating neuropsychiatric disorder widely believed to arise from defects during brain development. Indeed, dysfunction in the formation and function of GABAergic cortical interneurons has been implicated as a central pathogenic ...
Zarina Greenberg, Hayley Ramshaw, Quenten Schwarz   +2 more
doaj   +1 more source

Membrane resonance enables stable and robust gamma oscillations [PDF]

, 2012
Neuronal mechanisms underlying beta/gamma oscillations (20-80 Hz) are not completely understood. Here, we show that in vivo beta/gamma oscillations in the cat visual cortex sometimes exhibit remarkably stable frequency even when inputs fluctuate ...
Moca, Vasile V., Mureşan, Raul C., Nikolić, Danko, Singer, Wolf   +3 more
core   +1 more source

Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers

BMC Biology, 2020
Abnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory.
Kyerl Park, Jaedong Lee, H. Jang, B. Richards, M. Kohl, J. Kwag   +5 more
semanticscholar   +1 more source

Structural Changes Observed in the Piriform Cortex in a Rat Model of Pre-motor Parkinson’s Disease

Frontiers in Cellular Neuroscience, 2018
Early diagnosis of Parkinson’s disease (PD) offers perhaps, the most promising route to a successful clinical intervention, and the use of an animal model exhibiting symptoms comparable to those observed in PD patients in the early stage of the disease ...
Marco Sancandi, Emma Victoria Schul, Georgia Economides, Andrew Constanti, Audrey Mercer   +4 more
doaj   +1 more source

Differential expression of GABAA receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus

Frontiers in Cellular Neuroscience, 2023
Inhibitory γ-aminobutyric acid (GABA)-ergic interneurons mediate inhibition in neuronal circuitry and support normal brain function. Consequently, dysregulation of inhibition is implicated in various brain disorders.
Tzu-Hsuan Huang, Yi-Sian Lin, Yi-Sian Lin, Chiao-Wan Hsiao, Chiao-Wan Hsiao, Liang-Yun Wang, Musa Iyiola Ajibola, Musa Iyiola Ajibola, Wahab Imam Abdulmajeed, Wahab Imam Abdulmajeed, Wahab Imam Abdulmajeed, Yu-Ling Lin, Yu-Jui Li, Cho-Yi Chen, Cho-Yi Chen, Cheng-Chang Lien, Cheng-Chang Lien, Cheng-Chang Lien, Cheng-Chang Lien, Cheng-Di Chiu, Cheng-Di Chiu, Cheng-Di Chiu, Cheng-Di Chiu, Irene Han-Juo Cheng, Irene Han-Juo Cheng, Irene Han-Juo Cheng   +25 more
doaj   +1 more source

Adaptive disinhibitory gating by VIP interneurons permits associative learning

Nature Neuroscience, 2019
Learning drives behavioral adaptations necessary for survival. While plasticity of excitatory projection neurons during associative learning has been extensively studied, little is known about the contributions of local interneurons.
Sabine Krabbe, Enrica Paradiso, Simon d’Aquin, Y. Bitterman, J. Courtin, Chun Xu, Keisuke Yonehara, Milica Marković, C. Müller, Tobias Eichlisberger, Jan Gründemann, F. Ferraguti, A. Lüthi   +12 more
semanticscholar   +1 more source

Cholecystokinin-Expressing Interneurons of the Medial Prefrontal Cortex Mediate Working Memory Retrieval

Journal of Neuroscience, 2020
Distinct components of working memory are coordinated by different classes of inhibitory interneurons in the PFC, but the role of cholecystokinin (CCK)-positive interneurons remains enigmatic.
Robin Nguyen, Sridevi Venkatesan, Mary A. Binko, Jee Yoon Bang, Janine D. Cajanding, Chloe Briggs, D. Sargin, I. Imayoshi, E. Lambe, J. C. Kim   +9 more
semanticscholar   +1 more source