Results 81 to 90 of about 996,321 (170)

Adaptation of the secretory pathway in cancer through IRE1 signaling

, 2015
International audienceThe unfolded protein response (UPR) was originally identified as a signaling network coordinating adaptive and apoptotic responses to accumulation of unfolded proteins in the endoplasmic reticulum (ER).
Schmit, Kathleen, Stéphanie Lhomond, Kathleen Schmit, Fazli, Hélèna, Chevet, Eric, John B. Patterson, Dejeans, Nicolas, Taouji, Saïd, Nestor Pallares, Hélèna Fazli, Saïd Taouji, Lhomond, Stéphanie, Pallares, Nestor, Barroso, Kim, Patterson, John B., Nicolas Dejeans, Eric Chevet, Kim Barroso   +17 more
core   +1 more source

Effects of Ire1 gene on virulence and pathogenicity of Candida albicans

Open Life Sciences
With the extensive utilization of antifungal drugs, the drug resistance of Candida albicans is progressively intensifying, and the effect of empirical treatment for C. albicans infection is not evident.
Zhao Huihai, Qin Lixia, Li Mengyan, Jiang Mengyu, Cui Mengge, Wang Hua, Hou Baohua, Wang Fukun, Jia Keran   +8 more
doaj   +1 more source

Cardiopulmonary Bypass-Induced IL-17A Aggravates Caspase-12-Dependent Neuronal Apoptosis Through the Act1-IRE1-JNK1 Pathway

Biomolecules
Cardiopulmonary bypass (CPB) is associated with significant neurological complications, yet the mechanisms underlying brain injury remain unclear. This study investigated the role of interleukin-17A (IL-17A) in exacerbating CPB-induced neuronal apoptosis
Ruixue Zhao, Yajun Ma, Shujuan Li, Junfa Li   +3 more
doaj   +1 more source

ER Stress Regulates HIV Tat and Alcohol‐Induced NLRP6 Activation in Astrocytes

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
HIV Tat and ethanol synergistically induce ER stress in astrocytes, activating an ER stress‐NLRP6 inflammasome axis that drives caspase‐1 activation and IL‐1β/IL‐18 release. Targeting ER stress or NLRP6 effectively suppresses astrocytic neuroinflammation, identifying a novel therapeutic pathway for alcohol‐exacerbated NeuroHIV.
Seema Singh, Elias Horanieh, Shilpa Buch, Palsamy Periyasamy   +3 more
wiley   +1 more source

The IRE1-XBP1s Pathway Impairment Underpins NK Cell Dysfunction in Hodgkin Lymphoma, That Is Partly Restored By PD-1 Blockade

, 2019
Background: The frequent loss of Major Histocompatibility Complex I molecule (MHC-I) on Hodgkin/Reed-Sternberg (HRS)-cells renders them susceptible to Natural Killer (NK) cell-mediated lysis in Hodgkin Lymphoma (HL).
Cristino, Alexandre, Nourse, Jamie, Gandhi, Maher K, Bednarska, Karolina, Vari, Frank, Stehbens, Samantha, Mujaj, Sally, Thillaiyampalam, Gayathri, Cui, Qingyan, Gunawardana, Jay   +9 more
core   +1 more source

PDIA6 regulates insulin secretion by selectively inhibiting the RIDD activity of IRE1

, 2016
Protein disulfide isomerase A6 (PDIA6) interacts with protein kinase RNA-like endoplasmic reticulum kinase (PERK) and inositol requiring enzyme (IRE)-1 and inhibits their unfolded protein response signaling.
Eletto D., Argon Y., Boyle S.
core   +1 more source

Chronic XBP1s-mediated activation of the unfolded protein response impairs CD8+ T cell anti-tumor immunity

Frontiers in Immunology
CD8+ T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor microenvironment, and metabolic dysfunction.
Keith Alan Nair, Keith Alan Nair, Jessica Lee, Jessica Lee, Olivia Zaleski, Olivia Zaleski, Luciano Mazzoccoli, Luciano Mazzoccoli, Brian Deng, Brian Deng, Chih-Chi Andrew Hu, Stanley Ching-Cheng Huang, Stanley Ching-Cheng Huang, Andreas Wieland, Andreas Wieland, Hazem E. Ghoneim, Hazem E. Ghoneim, Haitao Wen, Haitao Wen, Xiaopei Huang, Xiaopei Huang, Bei Liu, Bei Liu   +22 more
doaj   +1 more source

Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis

JCI Insight, 2022
Kawasaki disease (KD) is the leading cause of noncongenital heart disease in children. Studies in mice and humans propound the NLRP3/IL-1β pathway as the principal driver of KD pathophysiology.
Stefanie Marek-Iannucci, Asli D. Yildirim, Syed M. Hamid, Asli B. Ozdemir, Angela C. Gomez, Begüm Kocatürk, Rebecca A. Porritt, Michael C. Fishbein, Takao Iwawaki, Magali Noval Rivas, Ebru Erbay, Moshe Arditi   +11 more
doaj   +1 more source

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee, Fahika Nazeerulla, Manash Kumar Paul, Sujit Kumar Bhutia, Deblina Basu, Subhadip Mukhopadhyay   +5 more
wiley   +1 more source

Single‐Cell Analysis of Cartilage‐Derived Cells Identifies Diverse Populations and a Cholesterol/ER‐Stress Chondrocyte Subset in Knee OA

Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.
ABSTRACT This study aimed to elucidate the cellular and molecular mechanisms underlying knee osteoarthritis pathogenesis by analyzing chondrocyte populations and their spatial distribution using single‐cell RNA sequencing (scRNA‐seq). Knee cartilage cells underwent scRNA‐seq.
Yu Kobori, Kohei Nishitani, Hiroyuki Yoshitomi, Akinori Murakami, Kazuki Ichiyanagi, Shigeo Yoshida, Jiu Tanaka, Shinichi Kuriyama, Shinichiro Nakamura, Akio Sakamoto, Takashi Noguchi, Yugo Morita, Takashi Sono, Takayuki Fujii, Koichi Murata, Junya Toguchida, Hideki Ueno, Yasuhiro Murakawa, Chikashi Terao, Shuichi Matsuda   +19 more
wiley   +1 more source