Results 101 to 110 of about 996,321 (170)

Investigation of IRE1/XBP1s pathway and its potential as a therapeutic target in breast cancer

, 2015
X-Box binding protein 1 (XBP1) is an integral component of the unfolded protein response (UPR), a pro-survival mechanism, triggered by the onset of endoplasmic reticulum stress.
Cleary, Patricia
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Structural and functional basis for RNA cleavage by Ire1 [PDF]

, 2011
Background: The unfolded protein response (UPR) controls the protein folding capacity of the endoplasmic reticulum (ER). Central to this signaling pathway is the ER-resident bifunctional transmembrane kinase/endoribonuclease Ire1.
Finer-Moore, J, Korennykh, AV, Stroud, RM, Zhang, C, Walter, P, Korostelev, AA, Shokat, KM, Egea, PF   +7 more
core   +1 more source

Ire1

Inositol-requiring 1 (IRE1), also known as endoplasmic reticulum (ER) to nucleus signaling 1 (ERN1), is a proximal sensor for the status of ER luminal protein folding in a stress response called the unfolded protein response (UPR). When unfolded proteins
Kaufman, R.J., Schröder, M.E.
core   +1 more source

Regulation of IRE1 RNase activity by the Ribonuclease inhibitor 1 (RNH1)

, 2019
Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the sensor inositol-requiring enzyme 1α (IRE1), an endoribonuclease that splices the mRNA of the transcription factor XBP1 (X-box-binding protein 1).
Celine Schaeffer (5633627), Quentin Tavernier (5633618), Luca Rampoldi (160772), Nicolas Pallet (506605), Evangeline Bennana (5633621), Virginie Poindessous (5633624), Nicolas Pietrancosta (2041915)   +6 more
core   +1 more source

PreS1 deletions in genotype C HBV leads to severe hepatic inflammation and hepatocarcinogenesis via the IRE1-JNK axis

JHEP Reports
Background & Aims: Deletion of 15–21 nucleotides covering the preS1 start codon frequently occurs in patients with chronic HBV (CHB) with HBV genotype C and has been reported to be related to progression to hepatocellular carcinoma (HCC).
Yu-Min Choi, Junghwa Jang, Dong Hyun Kim, Ziyun Kim, Eunseo Kim, Won Hyeok Choe, Bum-Joon Kim   +6 more
doaj   +1 more source

Hypoxic regulation of the expression of genes encoded estrogen related proteins in U87 glioma cells: eff ect of IRE1 inhibition

, 2017
Objective. The aim of the present study was to examine the effect of inhibition of endoplasmic reticulum stress signaling, mediated by IRE1 (inositol requiring enzyme 1), which is a central mediator of the unfolded protein response on the expression of ...
Do Minchenko, Oh Minchenko, Oo Ratushna, Ratushna Oo, Minchenko Oh, Minchenko Do, Oo Riabovol, Riabovol Oo   +7 more
core   +1 more source

M50 expression reduces IRE1 protein levels.

, 2013
(A) NIH-3T3 cells were cotransfected with plasmids encoding IRE1-HA (1 µg) and Flag-tagged M50 or m144 (0.5, 1, or 2 µg). After 24 h, cell lysates were analyzed by immunoblot using protein- or tag-specific antibodies. (B) NIH-3T3 cells were cotransfected
Julia M. Burkhart (443213), René P. Zahedi (443215), Matthias Budt (382049), Wolfram Brune (185524), Sebastian Stahl (443212), Hermine Mohr (160119), Florian Hinte (443214), Boaz Tirosh (204714), Zsolt Ruzsics (75383), Albert Sickmann (5325)   +9 more
core   +1 more source

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

, 2010
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an intracellular signaling pathway that adjusts the protein folding capacity of the ER according to need.
Shannon L. Behrman, Peter Walter, Alexei V. Korennykh, Han Li   +3 more
core   +1 more source

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1¿-XBP1 Signaling through a Physical Interaction

, 2010
Endoplasmic reticulum (ER) stress is a feature of secretory cells and of many diseases including cancer, neurodegeneration, and diabetes. Adaptation to ER stress depends on the activation of a signal transduction pathway known as the unfolded protein ...
Deegan, Shane, Deepti, Ayswaria, Gupta, Sanjeev, Samali, Afshin   +3 more
core   +1 more source

Mitochondria-derived oxidative factor activates IRE1.

, 2013
(a) Effects of Tg, antimycin A (AMA), or rotenone on the activation of ER stress sensors. IRE1 were immunoprecipitated before detection by western blottings.
Tomohisa Mori (474320), Tsung-Ping Su (90695), Teruo Hayashi (90690), Eri Hayashi (474321)   +3 more
core   +1 more source