Results 91 to 100 of about 996,321 (170)

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

The endoplasmic reticulum (ER) transporter solute carrier family 33 member 1 (SLC33A1) has emerged as an attractive therapeutic target in etiologically diverse diseases, ranging from lung cancer to neurodegenerative disorders.
Bora, Prerona, Saez, Enrique, Rafiq, Maria, Homan, Rick A., Sosna, Justyna, Lee, Thanh-Trang, Mindrebo, Jeffrey T., Kutseikin, Sergei, Lander, Gabriel C., Forli, Stefano, Birsoy, Kivanc, Qiu, Huang, Redkina, Anastasiya, Hu, Xiao, Petrassi, H. Michael, Wiseman, R. Luke, Liu, Shanshan, Parker, Christopher G., Holcomb, Matthew   +18 more
core   +1 more source

MCMV M50 interacts with IRE1.

, 2013
(A) NIH-3T3 cells stably expressing TEV-HA-tagged IRE1 were mock infected or infected with MCMV at an MOI of 5. Whole cell lysates (WCL) were applied to an anti-HA sepharose matrix.
Julia M. Burkhart (443213), René P. Zahedi (443215), Matthias Budt (382049), Wolfram Brune (185524), Sebastian Stahl (443212), Hermine Mohr (160119), Florian Hinte (443214), Boaz Tirosh (204714), Zsolt Ruzsics (75383), Albert Sickmann (5325)   +9 more
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Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility

Plant-Environment Interactions, Volume 7, Issue 5, October 2026.
ABSTRACT Plant lineage has traditionally constrained grafting compatibility, with monocots generally considered incompatible because of their dispersed vascular bundles and limited secondary growth. Recent studies have shown that embryonic grafting can establish successful graft unions in selected monocot systems by exploiting early developmental ...
Melagani Subash Chandra Gowda Sahaja, Melagani Subash Chandra Gowda Sahana, Revathi Thottathil, Chithra Rekha, Poomangalath Priyada, Vidhu Sankar Babu   +5 more
wiley   +1 more source

The Effects of Extracellular Vesicles From Cancer Cells in Acidosis or ER Stress to Endothelial Cells: Angiogenesis and Endothelial Activation

Biology of the Cell, Volume 118, Issue 10, October 2026.
When breast cancer cells experience ER stress, their large extracellular vesicles promote increased endothelial migration and endothelial permeability. When these cancer cells are adapted to acidosis, their extracellular vesicles increase permeability and migration, reduce angiogenesis and tumor cell adhesion to endothelia, and activate ER stress ...
Ana Sayuri Yamagata, Ramon H. G. Teles, Nicolas J. Villarinho, Ana Carolina Lima Ralph, Nicolly C. dos Santos, Kevin Perera, Gisela R. Terçarioli, Amanda Ikegami, Anayara Ristow, Daniel Pecoraro Demarque, Jeremy Newton, Luiz E. da Silva, Edmond W. K. Young, Ruy G. Jaeger, Vanessa Morais Freitas   +14 more
wiley   +1 more source

Substituted chromenones, IRE1 inhibitors, and methods of using same

, 2023
The present invention includes substituted chromenones that are useful to inhibit the IRE1/XBP-1 pathway. In certain embodiments, the compounds of the invention inhibit IRE1\u27s RNase activity.
Del Valle, Juan R., Hu, Chih-Chi Andrew
core  

Beta Cell Stress to Epitope Diversification: Post‐Translationally Modified Antigens in Type 1 Diabetes

Immunological Reviews, Volume 343, Issue 1, October 2026.
ABSTRACT Pancreatic beta cells are active participants in the loss of immune tolerance because their high secretory demand creates exceptional vulnerability to inflammatory exposure, endoplasmic reticulum (ER) stress, calcium dysregulation, and redox imbalance. These conditions can promote enzymatic and nonenzymatic changes in self‐proteins, generating
Megan L. Proffer, Saptarshi Roy, Jon D. Piganelli   +2 more
wiley   +1 more source

Protective effect of cannabinoid type 2 receptor agonist (JWH‐133) against hepatotoxicity induced by Prangos ferulacea Lindl. extract

Experimental Physiology, Volume 111, Issue 10, Page 4565-4577, 1 October 2026.
Abstract This study investigated Prangos ferulacea (PF)‐induced hepatotoxicity, its potential association with endoplasmic reticulum (ER) stress and proinflammatory cytokines, and the effect of the cannabinoid type 2 receptor agonist JWH‐133. Rats (n = 37) were divided into four groups: control–sham group (CSG, n = 9), PF extract group (PG, n = 9), PF ...
Mesut Çelik, Aslı Çetin Taşlıdere, Zeynal Mete Karaca, Halil Düzova, İbrahim Halil Geçibesler, Ali Rıza Çalişkan, Çağatay Taşkapan, Kübranur Korkmaz   +7 more
wiley   +1 more source

IRE1’nin iki farklı enzimatik aktivitelerinin biyolojik hedeflerinin ve rollerinin incelenmesi

, 2022
Cataloged from PDF version of article.Includes bibliographical references (leaves 119-132).The unfolded protein response (UPR) is composed of complex and intricate series of highly regulated pathways geared to resolve the accumulation of misfolded ...
Yıldırım, Aslı Dilber
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Inhibition of pro-apoptotic UPR pathways PERK/CHOP and IRE1/JNK protects differentiated SH-SY5Y cells against rotenone-induced toxicity

Frontiers in Molecular Neuroscience
IntroductionParkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by loss of dopaminergic neurons and α-synuclein aggregation in the midbrain.
Natalia Siwecka, Natalia Siwecka, Wioletta Rozpȩdek-Kamińska, Michał Golberg, Michał Golberg, Wojciech Wiese, Grzegorz Galita, Ireneusz Majsterek   +7 more
doaj   +1 more source

Phosphoregulation of Ire1 RNase splicing activity [PDF]

, 2014
20.05.14 KB. Ok to add published version to spiral, OA paperIre1 is activated in response to accumulation of misfolded proteins within the endoplasmic reticulum as part of the unfolded protein response (UPR). It is a unique enzyme, possessing both kinase
Prischi, F, Prischi, Filippo, Nowak, PR, Ali, MMU, Nowak, Piotr R, Carrara, M, Ali, Maruf MU, Carrara, Marta   +7 more
core   +1 more source