Results 231 to 240 of about 311,756 (304)

Association of HAMP Expression and CD8+ T‐Cell Infiltration With Atezolizumab–Bevacizumab Response in Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
In hepatocellular carcinoma treated with atezolizumab–bevacizumab, responders showed RNA‐seq enrichment of immune and chemokine pathways with higher HAMP expression. In resected specimens, immunohistochemistry confirmed increased intratumoral CD8+ T‐cell density and hepcidin (HAMP), supporting HAMP plus CD8 as components of a composite predictor of ...
Shun Nakamura, Yuki Murakami, Yusuke Oshima, Takashi Masuda, Wataru Miyoshino, Hiroomi Takayama, Yoko Kawano, Teijiro Hirashita, Yuichi Endo, Masafumi Inomata   +9 more
wiley   +1 more source

Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy. [PDF]

J Virol
Ma Z, Guo L, Ji R, Sun Z, Wang J, Yan Y, Liu K, Zhang H, Wang X, Wu C, Lian L, Cao W, Bai J, Jiang P, Liu X.   +14 more
europepmc   +1 more source

Plasma Immunoglobulin A and intestinal ultrasound: Novel indicators for disease activity monitoring in inflammatory bowel disease—Insights from a Taiwan cohort

Advances in Digestive Medicine, EarlyView.
Abstract Intestinal ultrasound (IUS) is a non‐invasive imaging method used to evaluate bowel wall inflammation and monitor disease activity in inflammatory bowel disease (IBD) patients. Both the European Crohn's and Colitis Organization and the American Gastroenterological Association endorse IUS for monitoring disease activity and identifying ...
Yu‐Lin Chen, Cheng‐Kuo Chen, Po‐Ju Huang, Hsing‐Hung Cheng, Wang‐De Hsiao, Pin‐Chun Huang, Tsung‐Lin Hsieh, Jia‐Sheng Wen, Tsung‐Yu Tsai   +8 more
wiley   +1 more source

A humanized transferrin receptor 1-transferrin model supports functional iron homeostasis and therapeutic delivery across the blood-brain barrier. [PDF]

J Biol Chem
Yesiltepe M, Metkar S, Yin T, Chakraborty I, D'Adamio L.   +4 more
europepmc   +1 more source

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

POLR1A inhibits ferroptosis by regulating TFAM-mediated mitophagy and iron homeostasis. [PDF]

Redox Biol
Zhang T, Gao Y, Harhai M, Jourdain AA, Marti TM, Vassella E, Yang Z, Zhou Q, Dorn P, Peng RW.   +9 more
europepmc   +1 more source

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non‐Finnish Patients

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Cytosolic phosphoenoylpyruvate carboxykinase (PEPCK‐C) is an essential, rate‐limiting enzyme in the gluconeogenesis pathway. PEPCK‐C deficiency presents with hypoglycaemia, hyperlactataemia and hepatopathy, and was first reported in association with bi‐allelic PCK1 variants in 2014.
Isaac Bernhardt, Polona Le Quesne Stabej, Claire Hart, Mark De Hora, Sarah Hulley, Mark Anderson, Harry G. Leitch, Hugh Lemonde, Bryony Ryder, James Davison   +9 more
wiley   +1 more source

Nanotuner targeting mitochondrial redox and iron homeostasis imbalance for the treatment of acute liver injury. [PDF]

Theranostics
Li M, Yang Q, Gao J, Liu X, Shi J, Guo W, Zhang Y, Yu Q, Sun X, Zhang S.   +9 more
europepmc   +1 more source

Predominance of Ferroptotic Cell Death Mechanisms in Substantia Nigra Neurodegeneration in Parkinson's Disease

Annals of Neurology, EarlyView.
Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng, Anusha Jayaraman, Richard Reynolds, Jia Nee Foo   +3 more
wiley   +1 more source

Artesunate induces ferroptosis in gastric cancer by targeting the TFRC-HSPA9 axis for iron homeostasis regulation. [PDF]

Redox Biol
Liu Y, Yu Y, Luo Z, Fang R, Zhang X, Liao Z, Li W.   +6 more
europepmc   +1 more source