Results 271 to 280 of about 311,756 (304)

Aluminium toxicity and iron homeostasis

Journal of Inorganic Biochemistry, 2001
In an animal model of aluminum overload, (aluminium gluconate), the increases in tissue aluminium content were paralleled by elevations of tissue iron in the kidney, liver heart and spleen as well as in various brain regions, frontal, temporal and parietal cortex and hippocampus.
R J, Ward, Y, Zhang, R R, Crichton
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Iron Homeostasis in the Liver

Comprehensive Physiology, 2013
AbstractIron is an essential nutrient that is tightly regulated. A principal function of the liver is the regulation of iron homeostasis. The liver senses changes in systemic iron requirements and can regulate iron concentrations in a robust and rapid manner. The last 10 years have led to the discovery of several regulatory mechanisms in the liver that
Erik R, Anderson, Yatrik M, Shah
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Iron homeostasis: casting new roles

Blood, 2008
In this issue of Blood, Folgueras and colleagues show that the transmembrane serine protease matriptase-2 plays an essential role in the regulation of systemic iron homeostasis.
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Cytokines, Iron Homeostasis, and Cancer

1994
Iron is of central importance to all, from bacteria to higher eukaryotes.1–3 It is critical for such important cellular processes as DNA synthesis, cellular respiration, and oxygen transport. However, iron also is a catalytic participant in the generation of damaging oxygen free radicals.
F M, Torti, S V, Torti
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Regulation of mammalian iron homeostasis

Current Opinion in Clinical Nutrition and Metabolic Care, 2000
Iron homeostasis is regulated with respect to uptake, storage and utilization. Newer work is presented that defines proteins responsible for iron transport, sequestration and sensing, and that addresses their regulation at the cellular and organismal levels by ambient iron concentrations, demand for erythropoiesis, body iron burden, and redox stimuli.
B D, Schneider, E A, Leibold
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Iron Homeostasis in the Neonate

Pediatrics, 2009
The regulation of the availability of micronutrients is particularly critical during periods of rapid growth and differentiation such as the fetal and neonatal stages. Both iron deficiency and excess during the early weeks of life can have severe effects on neurodevelopment that may persist into adulthood and may not be corrected by restoration of ...
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Regulation of systemic iron homeostasis

Current Opinion in Hematology, 2013
The circulating peptide hepcidin modulates systemic iron balance by limiting the absorption of dietary iron and the release of iron from macrophage stores. Recent studies conducted in humans, animal models, and tissue culture systems have enhanced our understanding of the molecular mechanisms by which hepcidin levels are altered in response to iron ...
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Brain iron homeostasis.

Danish medical bulletin, 2003
Iron is essential for virtually all types of cells and organisms. The significance of the iron for brain function is reflected by the presence of receptors for transferrin on brain capillary endothelial cells. The transport of iron into the brain from the circulation is regulated so that the extraction of iron by brain capillary endothelial cells is ...
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Iron homeostasis and nutritional iron deficiency.

The Journal of nutrition, 2011
Nonheme food ferritin (FTN) iron minerals, nonheme iron complexes, and heme iron contribute to the balance between food iron absorption and body iron homeostasis. Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2. Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN,
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Iron-homeostasis and obesity

Journal of Trace Elements in Medicine and Biology, 2015
Christiane, Becker, Klaus, Schümann
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