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Glycolysis enzymes and cellular lactylation in tumour [PDF]
Clinical and Translational MedicineCellular lactylation, a recently identified post‐translational modification, has emerged as a crucial regulator in various biological processes, particularly in cancer.
Chenyuan Dai, Lihua Wang
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Lactylation in tumor: mechanisms and therapeutic potentials [PDF]
Frontiers in ImmunologyLactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation.
Dandan Wang, Hao Rong, Ke Ma, Jun Peng
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Progress of Research on the Metabolic Regulation of Lactylation in Muscle Tissues and Its Disease Associations [PDF]
BiomoleculesLactylation serves as a vital link between cellular metabolism and epigenetic regulation and plays a pivotal role in muscle biology. Muscle tissue is the primary site of lactate production; its unique metabolic environment confers dynamism, specificity ...
Zhihang Wang +7 more
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Lactylation and tumor immune regulation: insights from recent studies [PDF]
Frontiers in ImmunologyLactate, a major product of glycolysis, accumulates abundantly in the tumor microenvironment (TME), serving not only as a hallmark of metabolic dysregulation but also as a key driver of immunosuppression.
Chunhong Li +3 more
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BMC Biology, 2023 Background The aim of study was to observe the effect of increased lactate levels during high-intensity interval training (HIIT) on protein lactylation, identify the target protein, and investigate the regulatory effect of lactylation on the function of ...
Xuefei Chen +7 more
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Deciphering novel enzymatic and non-enzymatic lysine lactylation in Salmonella
Emerging Microbes and InfectionsLysine lactylation, a novel post-translational modification, is involved in multiple cellular processes. The role of lactylation remains largely unknown, especially in bacteria.
Chuanzhen Zhang +8 more
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Genome Biology, 2021 Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu +6 more
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HeliyonBackground: Lactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, the association between lactylation and prognosis, tumor microenvironment (TME), and response to ...
Zhixuan Wu +7 more
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Predicting lymphoma prognosis using machine learning-based genes associated with lactylation
Translational OncologyBackground: Lactylation, a newly discovered PTM involving lactic acid, is linked to solid tumor proliferation and metastasis. Lymphoma patients exhibit high lactic acid levels, yet lactylation's role in lymphoma is underexplored.
Miao Zhu +7 more
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Lactylation in cancer: Mechanisms in tumour biology and therapeutic potentials
Clinical and Translational MedicineLactylation, a recently identified form of protein post‐translational modification (PTM), has emerged as a key player in cancer biology. The Warburg effect, a hallmark of tumour metabolism, underscores the significance of lactylation in cancer ...
Yipeng He +8 more
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