Results 91 to 100 of about 5,526 (234)

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source

Lactylation in diabetes mellitus and its complications: mechanisms of action and therapeutic potential - recent advances [PDF]

BackgroundDiabetes mellitus (DM) and its complications represent a global health burden. Lactylation, a novel post-translational modification (PTM) linking metabolism to epigenetic regulation, has emerged as a key mediator in metabolic disorders ...
Lan Liu, Min Zhou, Xiaoshu Wang, Yihong Sun   +3 more
core   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science
Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
doaj   +1 more source

Lactylation’s role in bone health and disease: mechanistic insights and therapeutic potential [PDF]

PeerJ
This article reviews the mechanisms and research progress of lactylation, an emerging post-translational modification (PTM) of proteins, in bone metabolism and related diseases.
Zhiyuan Ye, Xuanyu Chen, Jiyuan Zou, Wenjing Wu, Jingyuan Yang, Li Yang, Lvhua Guo, Tao Luo   +7 more
doaj   +2 more sources

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Lactate-induced histone lactylation by p300 promotes osteoblast differentiation [PDF]

昭和大学博士(歯学)2023年度doctoral ...
南, えりか
core  

Lactate-induced lactylation: from basic research to clinical perspectives [PDF]

Lactate was initially considered a metabolic waste product of glycolysis under hypoxic conditions until the emergence of the lactate shuttle hypothesis.
Bin Liu, Henghe Shi, Junduo Wu, Sijie Jin, Yifei Zou   +4 more
core   +1 more source

Lactate and lysine lactylation of histone regulate transcription in cancer

Heliyon
Histone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang, Nanzhi Luo, Zhipeng Gong, Wenjing Zhou, Yin Ku, Yaohui Chen   +5 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Non-histone lactylation: unveiling its functional significance [PDF]

Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on ...
Pusong Shi, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma   +10 more
core   +1 more source