Results 111 to 120 of about 5,526 (234)
Advanced Science, Volume 13, Issue 16, 18 March 2026.Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang +10 more
wiley +1 more source
Potential role of lactylation in intrinsic immune pathways in lung cancer
Frontiers in PharmacologyLung cancer, one of the most lethal malignancies, has seen its therapeutic strategies become a focal point of significant scientific attention. Intrinsic immune signaling pathways play crucial roles in anti-tumor immunity but face clinical application ...
Mengdie Huang +3 more
doaj +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen +12 more
wiley +1 more source
Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue [PDF]
IntroductionThis study explores the effects of moderate-intensity exercise on protein lactylation in mouse muscle tissue metabolism.MethodsHealthy adult mice running for 6 weeks as an exercise model and sedentary mice as the control were used to perform ...
Fang Wang +12 more
core +1 more source
Post‐Translational Modifications in Animal Circadian Clocks
Advanced Science, Volume 13, Issue 16, 18 March 2026.Circadian clocks coordinate physiology with daily environmental cycles through conserved transcriptional–translational feedback loops. This review summarizes how post‐translational modifications fine‐tune clock function, highlights the evolutionary convergence of circadian timekeeping in Drosophila and mammals, and emphasizes the central of these ...
Xianhui Liu, Yong Zhang
wiley +1 more source
Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies [PDF]
Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin the genesis ...
Alcon-Rodriguez, Sergio +7 more
core +1 more source
Discover OncologyBackground Glioblastoma (GBM) is a highly aggressive brain tumor characterized by immunosuppressive tumor microenvironment and metabolic reprogramming. Dysregulated lactate metabolism has been observed in the glioma microenvironment, yet the functional ...
Huan Zhu +6 more
doaj +1 more source
Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases
BiomoleculesLactylation, a recently identified post-translational modification (PTM) triggered by excessive lactate accumulation, has emerged as a crucial regulator linking metabolic reprogramming to pathological processes in liver diseases.
Qinghai Tan, Mei Liu, Xiang Tao
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Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source