Results 141 to 150 of about 5,526 (234)

Characterization of lactylation modification subtypes and the promoting role of CCL20 in hepatocellular carcinoma progression

Frontiers in Genetics
BackgroundHepatocellular carcinoma (HCC) is a highly aggressive and deadly malignancy. Early identification of prognostic risk factors is crucial for guiding clinical management and improving patient outcomes.
Li-Hong Wu, Liu Yang, Xiang-Xu Wang, Shuang Bai, Xi Yan, Jing Wei, Jun Wang, Fei Tian   +7 more
doaj   +1 more source

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao   +6 more
wiley   +1 more source

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Journal of Experimental & Clinical Cancer Research
Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.
Liu, Jiena, Zhao, Liuying, Yan, Meisi, Jin, Shengye, Shang, Lingmin, Wang, Jianyu, Wang, Qin, Zhao, Shilu, Shen, Zibo, Liu, Tong, Wu, Hao, Pang, Da   +11 more
openaire   +2 more sources

YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes

Advanced Science
Activated microglia in the retina are essential for the development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates in multiple inflammatory and immune‐mediated diseases.
Jiaxing Huang, Xiaotang Wang, Na Li, Wei Fan, Xingran Li, Qian Zhou, Jiangyi Liu, Wanqian Li, Zhi Zhang, Xiaoyan Liu, Shuhao Zeng, Hui Yang, Meng Tian, Peizeng Yang, Shengping Hou   +14 more
doaj   +1 more source

Innate Immunity Champions: The Diverse Functions of Macrophages [PDF]

Macrophages are instrumental in maintaining tissue homeostasis, modulating inflammation and driving regeneration. The advent of omics techniques has led to the identification of numerous tissue-specific macrophage subtypes, thereby introducing the ...
Biscu, Francesca, Cicia, Donatella, Matteoli, Gianluca, Pridans, Clare, Zouzaf, Anissa   +4 more
core  

Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications

Drug Design, Development and Therapy
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
doaj  

Lactylation: a metabolic-epigenetic bridge in diabetic kidney disease and a therapeutic target for TCM. [PDF]

Chin Med
Zhang W, Zhu X, Zhang Y, Yang J, Sun X, Wang J, Zhang B.   +6 more
europepmc   +1 more source

Fusobacterium nucleatum promotes tumor progression driven by histone lactylation through increasing GLUT1 expression in colorectal cancer. [PDF]

J Transl Med
Zhou S, Wang K, Wang H, Yuan Q, Yu X, Li L, Shi L, Hu Q, Liu L, Ding C.   +9 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in cancer. [PDF]

Mol Biomed
Liu Z, Li A, Ma Z, Wang J, Chen X, Wang Z, Fu R.   +6 more
europepmc   +1 more source

Lactylation as a metabolic-epigenetic switch: Mechanisms and roles in cancer, sepsis, trauma, inflammation, and tissue repair. [PDF]

Biochem Biophys Rep
Bar-Or D, Banton K, Acuna D, Williams J, Palacio CH, Zaw-Mon C, Garrett R, Crawley T, Paredes D.   +8 more
europepmc   +1 more source