Results 11 to 20 of about 5,526 (234)

H3K18 lactylation marks tissue-specific active enhancers [PDF]

Genome Biology, 2022
Abstract Background Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation. Results Given the expected relevance of this modification and current limited knowledge of its ...
Galle, Eva, Wong, Chee-Wai, Ghosh, Adhideb, Desgeorges, Thibaut, Melrose, Kate, Hinte, Laura C, Castellano-Castillo, Daniel, Engl, Magdalena, de Sousa, Joao Agostinho, Ruiz-Ojeda, Francisco Javier, De Bock, Katrien, Ruiz, Jonatan R, von Meyenn, Ferdinand   +12 more
core   +10 more sources

Dynamic investigation of hypoxia-induced L-lactylation [PDF]

Proceedings of the National Academy of Sciences
The recently identified histone modification lysine lactylation can be stimulated by L-lactate and glycolysis. Although the chemical group added upon lysine lactylation was originally proposed to be the L-enantiomer of lactate (K L-la ), two isomeric modifications, lysine D-lactylation (K D-la
Jinjun Gao, Ruilong Liu, Kevin Huang, Ziyuan Li, Xinlei Sheng, Kasturi Chakraborty, Chang Han, Di Zhang, Lev Becker, Yingming Zhao   +9 more
openaire   +5 more sources

Lactylation: The emerging frontier in post-translational modification [PDF]

Frontiers in Genetics
Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Zhou Lu, Xueting Zheng, Mingsong Shi, Yuan Yin, Yuanyuan Liang, Zhiyan Zou, Chenghe Ding, Yuanjing He, Yan Zhou, Xiaoan Li, Xiaoan Li   +10 more
doaj   +3 more sources

Lactylation and Central Nervous System Diseases

Brain Sciences
As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions ...
Ye Chen, Dongqiong Xiao, Xihong Li
doaj   +3 more sources

Resistance training in humans and mechanical overload in rodents do not elevate muscle protein lactylation [PDF]

, 2023
Although several reports have hypothesized that exercise may increase skeletal muscle protein lactylation, empirical evidence in humans is lacking.
Anglin, Derick A., Fei, Shengyi, Godwin, Joshua S., Kontos, Nicholas J., Mattingly, Madison L., McIntosh, Mason C., Michel, J. Max, Mobley, C. Brooks, Phillips, Stuart M., Plotkin, Daniel L., Roberts, Michael D., Ruple, Auburn University A., Sexton, Casey L., Smith, Morgan A., Vann, Christopher G., Vechetti, Ivan Jose, Jr   +15 more
core   +5 more sources

Lactate Promotes Macrophage HMGB1 Lactylation, Acetylation, and Exosomal Release in Polymicrobial Sepsis [PDF]

, 2021
High circulating levels of lactate and high mobility group box-1 (HMGB1) are associated with the severity and mortality of sepsis. However, it is unclear whether lactate could promote HMGB1 release during sepsis.
Fan, Min, Gill, P. S., Ha, Tuanzhu, Li, Chuanfu, Liu, Li, Tu, Fei, Wang, Xiaohui, Wang, Yana, Williams, David L., Xu, Jingjing, Yang, Kun   +10 more
core   +2 more sources

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

Protein lactylation induced by neural excitation [PDF]

Cell Reports, 2021
AbstractLactate is known to have diverse roles in the brain at the molecular and behavioral levels under both physiological and pathophysiological conditions, such as learning and memory and regulation of mood. Recently, a novel post-translational modification called lysine lactylation has been found in histone H3 of mouse macrophages, and the ...
Hideo Hagihara, Hirotaka Shoji, Hikari Otabi, Atsushi Toyoda, Kaoru Katoh, Masakazu Namihira, Tsuyoshi Miyakawa   +6 more
openaire   +3 more sources

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Ouyang Q, Hu Q, Wang C, He Y, Zeng R, Li Y, Su C, Lu G, Zhu X, Xiao L, Zhou H.   +10 more
europepmc   +2 more sources

Role of D(-)-Lactic Acid in Prevention of Chlamydia trachomatis Infection in an In Vitro Model of HeLa Cells [PDF]

, 2023
A vaginal microbiota dominated by certain Lactobacillus species may have a protective effect against Chlamydia trachomatis infection. One of the key antimicrobial compounds produced is lactic acid, which is believed to play a central role in host defense.
Calonghi, Natalia, Djusse, Marielle Ezekielle, Fato, Romana, Foschi, Claudio, Marangoni, Antonella, Marziali, Giacomo, Morselli, Sara, Naldi, Marina, Rizzardi, Nicola, Zalambani, Chiara   +9 more
core   +1 more source