Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells. [PDF]
, 2019 Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding ...
Brooks, George A +4 more
core +1 more source
The Metabolic-Epigenetic Nexus in Type 2 Diabetes Mellitus [PDF]
, 2021 The prevalence of type 2 diabetes mellitus (T2DM) continues to rise globally. Yet the aetiology and pathophysiology of this noncommunicable, polygenic disease, is poorly understood.
Davison, Gareth +2 more
core +2 more sources
Membrane-enclosed multienzyme (MEME) synthesis of 2,7-anhydro-sialic acid derivatives [PDF]
, 2017 Naturally occurring 2,7-anhydro-alpha-N-acetylneuraminic acid (2,7-anhydro-Neu5Ac) is a transglycosylation product of bacterial intramolecular trans-sialidases (IT-sialidases).
Andrew Bell +41 more
core +2 more sources
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
core +2 more sources
Impact of Physical Activity and Exercise on the Epigenome in Skeletal Muscle and Effects on Systemic Metabolism [PDF]
, 2022 Julio Plaza-Diaz and Concepcion M. Aguilera are part of the "UGR Plan Propio de Investigacion 2016" and the "Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada".
Aguilera, Concepción M. +5 more
core +1 more source
Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis [PDF]
Nature Chemical BiologyAbstractLysine l-lactylation (Kl-la) is a novel protein posttranslational modification (PTM) driven by l-lactate. This PTM has three isomers: Kl-la, N-ε-(carboxyethyl)-lysine (Kce) and d-lactyl-lysine (Kd-la), which are often confused in the context of the Warburg effect and nuclear presence. Here we introduce two methods to differentiate these isomers:
Di Zhang +16 more
openaire +3 more sources
Integration of transcriptional and metabolic control in macrophage activation [PDF]
, 2021 Macrophages react to microbial and endogenous danger signals by activating a broad panel of effector and homeostatic responses. Such responses entail rapid and stimulus-specific changes in gene expression programs accompanied by extensive rewiring of ...
Ghisletti S +3 more
core +1 more source
Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies [PDF]
, 2023 Some metabolic diseases, such as diabetes and hyperlipidemia, are associated with a state of inflammation, which adversely affects cardiovascular health.
Akbar, Naveed +3 more
core +2 more sources
Lactate Suppresses Immunometabolic and Inflammatory Responses in Monocytes [PDF]
, 2022 Many diseases are preventable through regular exercise. However, high-intensity exercise can transiently suppress immune function. Lactate can decrease inflammatory responses through epigenetic modifications such as histone lactylation, inhibiting ...
Davis, Kierstin Lynn
core +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source