Results 31 to 40 of about 5,526 (234)

Histone lactylation: a new epigenetic mark in the malaria parasite Plasmodium [PDF]

Epigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum. Here, we characterised a new epigenetic mark, histone lactylation, for the first time in Plasmodium: it was found in two human malaria parasites, P ...

core   +2 more sources

Lysine lactylation in diseases: beyond histone lactylation

Cell Death & Disease
Abstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Yiming Liu, Xuan Guo, Xinyang Hu, Sining Zhou, Qi Yang, Pingping Feng, Linghui Zeng   +6 more
openaire   +1 more source

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Lactate:A key regulator of the immune response [PDF]

Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells-with the latter process known as the Warburg effect-is historically considered a mere waste product of cell and tissue metabolism. However, research over
Certo, Michelangelo, Gope, Atrayee, Kucuk, Salih, Llibre, Alba, Mauro, Claudio   +4 more
core   +1 more source

The expanding constellation of histone post-translational modifications in the epigenetic landscape [PDF]

, 2021
The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and
Cavalieri V.
core   +1 more source

Lactylation and human disease

Expert Reviews in Molecular Medicine
Abstract Background Lactylation, a new epigenetic modification, is an important way in which lactate exerts physiological functions. There is a close relationship between increased lactylations caused by lactate and glycolysis, which can interact and play a role in disease through lactate as an intermediate mediator.
Linlin Wan, HuiJuan Zhang, Jialing Liu, Qian He, Jiumei Zhao, Chenglong Pan, Kepu Zheng, Yu Tang   +7 more
openaire   +2 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages [PDF]

, 2023
Type I interferons (IFNs) are the major host defence against viral infection and are induced following activation of cell surface or intracellular pattern recognition receptors, including retinoic-acid-inducible gene I (RIG-I)-like receptors (RLRs).
James, William, McKeating, Jane A, Schilling, Mirjam, Vaughan-Jackson, Alun   +3 more
core   +2 more sources

UBE2T‐Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation‐Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer

Advanced Science, EarlyView.
This study integrates multi‐omics to reveal the critical role of UBE2T in driving malignancy and stromal co‐evolution in PDAC. UBE2T potentiates glycolysis by regulating p53 degradation via a positive feedback loop, thereby promoting histone H3 lysine 18 lactylation in CAFs and stromal deposition. The UBE2T inhibitor PGG represents a potential strategy
Yong Ma, Wenbo Liu, Mingdou Li, Tao Wang, Bin Zhao, Keshen Wang, Qichen He, Haonan Sun, Huiguo Qing, Xiaoying Guan, Wengui Shi, Long Qin, Yuman Dong, Huinian Zhou, Zeyuan Yu, Xiangyan Jiang, Zuoyi Jiao   +16 more
wiley   +1 more source

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

Molecular Cancer
Background Aberrant RHOA activation drives tumor progression, yet regulatory mechanisms beyond genetic mutations remain poorly defined. Lactylation, a lactate-derived post-translational modification, links metabolic reprogramming to oncogenesis, but its ...
Chenglong Ma, Ruocen Liao, Xingyu Chen, Qianhua Cao, Xinyue Deng, Zhijun Dai, Chenfang Dong   +6 more
doaj   +1 more source