Results 41 to 50 of about 5,526 (234)

Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges

Journal of Advanced Research
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming’s team from the University of Chicago found that lactate could also be used as a substrate to induce histone lactylation and regulate gene ...
Xue-ting Hu, Xiao-feng Wu, Jin-yi Xu, Xiang Xu   +3 more
doaj   +1 more source

Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer

Frontiers in Immunology, 2023
BackgroundThe epigenetic regulatory chemical lactate is a product of glycolysis. It can regulate gene expression through histone lactylation, thereby promoting tumor proliferation, metastasis, and immunosuppression.MethodsIn this study, a lactylation ...
Hao Yang, Xiaoming Zou, Shifeng Yang, Ange Zhang, Nana Li, Zhen Ma   +5 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The LDH-H3K18La-Nur77 Axis Potentiates Immune Escape in Small Cell Lung Cancer [PDF]

Small cell lung cancer (SCLC) remains a therapeutic challenge due to its aggressive nature and limited response to immunotherapy. This study identifies lactate-induced histone lactylation as a novel epigenetic mechanism in SCLC, contributing to immune ...
Cheng, Bo, Guo, Kaiyue, Huang, Chenhan, Jiang, Dizhi, Li, Zerun, Ma, Xinyue, Mao, Hongyuan, Shang, Xiaoling, Tang, Ning, Wang, Haiyong, Wang, Liwen, Wang, Ruiqing, Wang, Tianzi, Zhang, Chenyue, Zhang, Xinyu, Zhang, Xun, Zhao, Chenglong   +16 more
core   +1 more source

Lactylation-related gene signature for prognostic prediction and immune infiltration analysis in breast cancer

Heliyon
Background: Lactylation is implicated in various aspects of tumor biology, but its relation to breast cancer remains poorly understood. This study aimed to explore the roles of the lactylation-related genes in breast cancer and its association with the ...
Yangchi Jiao, Fuqing Ji, Lan Hou, Yonggang Lv, Juliang Zhang   +4 more
doaj   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis‐Associated Acute Kidney Injury

Advanced Science
Histone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Jiao Qiao, Yuan Tan, Hongchao Liu, Boxin Yang, Qian Zhang, Qi Liu, Wenyuan Sun, Zhongxin Li, Qingchen Wang, Weimin Feng, Shuo Yang, Liyan Cui   +11 more
doaj   +1 more source

Identification of A p300–SP1–BRD4 Transcriptional Axis as a Key Driver of AR Hyperactivation in Polycystic Ovarian Syndrome

Advanced Science, EarlyView.
This study reveals a pivotal epigenetic regulatory role for the histone acetyltransferase p300, demonstrating that its acetylation of histone 3 at lysine 18 and 27 (H3K18ac and H3K27ac), alongside the formation of the p300/BRD4/SP1 complex, drives AR activation and ovarian fibrosis in PCOS.
Zhengquan Zhu, Yihan Wang, Haiyun Chen, Xinye Yu, Tingyu Wang, Yajing Weng, Meihong Guo, Ying Huang, Gaojian Tao, Wangsen Cao, Yong Wang, Daojuan Wang   +11 more
wiley   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Lactylation in ischemic brain injury—metabolic mechanisms, neuroinflammation, and therapeutic targets: A review [PDF]

Cerebral ischemic injury, a major cause of mortality and disability, results from reduced or interrupted blood flow to the brain, most commonly in ischemic stroke.
Guo, Yan, Ji, Xinchen, Liu, Miao, Lu, Jing, Wang, Ke, Zhao, Dexi   +5 more
core   +2 more sources