Results 71 to 80 of about 5,526 (234)

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Exploring the link between environmental chemical exposures and epigenetic modifications in diabetes mellitus [PDF]

Diabetes mellitus (DM) is a globally prevalent metabolic disorder characterized by impaired glucose homeostasis and insulin secretion. Beyond traditional risk factors like lifestyle and genetics, environmental pollutants, including particulate matter ...
Abunada, Hanan H., Hussein, Ola J., Korashy, Hesham M., Maayah, Zaid H., Matarid, Tasnim R., Rayan, Menatallah   +5 more
core   +2 more sources

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

Advanced Science
Epigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes.
Fanju Meng, Jianuo He, Xuebin Zhang, Wencong Lyu, Ran Wei, Shiyi Wang, Zhehao Du, Haochen Wang, Jinlong Bi, Xueyang Hua, Chao Zhang, Yiting Guan, Guoliang Lyu, Xiao‐Li Tian, Lijun Zhang, Wenbing Xie, Wei Tao   +16 more
doaj   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Beyond IDO1: Systems-Level Insights Into Enzymatic Networks And Regulatory Mechanisms In Cancer Immunotherapy Resistance [PDF]

Background: Cancer immunotherapy resistance affects 60-80% of patients receiving immune checkpoint inhibitors. The failure of IDO1 inhibitors in ECHO-301—despite achieving >90% target engagement—revealed critical gaps in understanding ...
Meera Indracanti, Muni Kumar Dokka, Madhumita Panda, Padmaja Musunuri, Nagendra Babu Gundamraju
core   +2 more sources

Multi-omics analysis of the HMGB2+ tumor epithelial cells in lactylation subgroups in colorectal cancer

Cell & Bioscience
Colorectal cancer (CRC) is a prevalent malignancy, yet the role of lactylation in its progression remains unclear. This study investigates High Mobility Group Box 2 positive tumor epithelial cells (HMGB2+Epi), a lactylation-associated subpopulation.
Shangshang Hu, Jinwei Lou, Muzi Ding, Yuhan Chen, Jian Qin, Zixuan Liu, Yue Li, QianNi Xiao, Mu Xu, Huiling Sun, Yuqin Pan, Shukui Wang   +11 more
doaj   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

Lactate-driven lactylation of HNRNPA1 orchestrates PKM2 splicing and glycolytic reprogramming in bladder cancer

Journal of Experimental & Clinical Cancer Research
Background Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a regulator of tumor metabolism. However, its functional relevance and molecular targets in bladder cancer (BLCA) remain unclear.
Tianqi Wang, Xiaohong Ma, Yini Wang, Hongquan Liu, Guixin Ding, Yanfei Li, Hejia Yuan, Jie Gao, Fengze Sun, Yicheng Guo, Jian Ma, Jitao Wu   +11 more
doaj   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ferroptosis inhibitor), lactate (LA), sh‐β‐catenin (shRNA of β‐catenin), or SKL2001 (an agonist ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
wiley   +1 more source

Air pollution and alveolar health [PDF]

Exposure to air pollution has been associated with up to 9 million premature deaths per year worldwide, with the respiratory system a key site for its effects.
Richeldi, Luca, Sofia, Carmelo
core   +1 more source