Results 81 to 90 of about 5,526 (234)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions [PDF]

Epigenetic changes are changes in gene expression that do not involve alterations to the DNA sequence. These changes lead to establishing a so-called epigenetic code that dictates which and when genes are activated, thus orchestrating gene regulation and
Castagna, Claudia, Lossi, Laura, Merighi, Adalberto   +2 more
core   +1 more source

Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia

Frontiers in Neurology
BackgroundVascular dementia (VD) is the only preventable form of dementia-related disease. Electroacupuncture (EA) has been shown to provide significant benefits in the treatment of VD.
Yinghua Chen, Wei Sun, Wei Sun, Zhongren Sun, Hongxu Zhao, Tong Wu, Yuanyu Song, Haoyu Wang, Haoyu Wang, Ruiqi Qin, Xiaoqing Su, Junfeng Li, Junfeng Li, Yue Miao, Xinran Li, Lin Wu   +15 more
doaj   +1 more source

Lactate and lactylation in cancer

Signal Transduction and Targeted Therapy
Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation and fate regulation in physiological and pathological settings, particularly in intricate conditions such as cancer. Specifically, lactate has been demonstrated to be pivotal in molding the tumor microenvironment (TME ...
Jie Chen, Ziyue Huang, Ya Chen, Hao Tian, Peiwei Chai, Yongning Shen, Yiran Yao, Shiqiong Xu, Shengfang Ge, Renbing Jia   +9 more
openaire   +3 more sources

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, EarlyView.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

The role of protein lactylation in brain health and disease: current advances and future directions

Cell Death Discovery
Lactate, the end product of glycolysis, plays a crucial role in cellular signaling and metabolism. The discovery of lactylation, a novel post-translational modification, has uncovered the role of lactate in regulating diseases, especially in the brain ...
Mingrui Han, Wenfeng He, Wengen Zhu, Linjuan Guo   +3 more
doaj   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Metabolic-epigenetic regulation of macrophage polarization. [PDF]

, 2021
Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion, which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. Highly
Noe, Jordan T.
core   +1 more source

Roles of lactylation in lipid metabolism and related diseases

Cell Death Discovery
Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction.
Bing Zhao, Zhuoqing Lan, Caixia Li, Hao Wang   +3 more
doaj   +1 more source