Leptin signaling and leptin resistance [PDF]
Medical Review, 2022 With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine,
Liu Jiarui +3 more
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Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions [PDF]
Endocrine ConnectionsLeptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Wenjing Hu, Huijuan Zhu, Fengying Gong
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STAT3 phosphorylation in central leptin resistance [PDF]
Nutrition & Metabolism, 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu +3 more
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Leptin resistance: underlying mechanisms and diagnosis [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2019 Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O +4 more
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Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]
PLoS ONE, 2016 Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura +6 more
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The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity [PDF]
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh +7 more
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Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications [PDF]
BiomedicinesBackground: Leptin, an adipokine essential for regulating energy balance, exerts important effects on brain function, notably within the hippocampus, a region integral to learning and memory.
Ismael Valladolid-Acebes
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The Phlorotannin-Rich Fraction of Ecklonia cava Extract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue [PDF]
International Journal of Endocrinology, 2020 Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of leptin and leptin resistance in adipocytes. In the present study, we evaluated the effects of Ecklonia cava
Myeongjoo Son +7 more
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Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats [PDF]
Heliyon, 2021 Leptin and hypothalamic-adipose lipid handling are relevant in determining the shift of metabolic activities. There are scanty findings connecting glucose dysregulation as a result of hyperandrogenism during gestation to hypothalamic-adipose axis and ...
Emmanuel Damilare Areola +9 more
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Systemic and Local Leptin Resistance in Patients with Cardiovascular Diseases [PDF]
DiagnosticsBackground/Objectives: The causes and mechanisms underlying the development of leptin resistance (LR) in patients with cardiovascular disease (CVD) remain unknown.
Olga Gruzdeva +8 more
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