Leptin signaling and leptin resistance [PDF]
Medical Review, 2022 With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine,
Liu Jiarui +3 more
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STAT3 phosphorylation in central leptin resistance [PDF]
Nutrition & Metabolism, 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Huimin Liu +3 more
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Systemic and Local Leptin Resistance in Patients with Cardiovascular Diseases [PDF]
DiagnosticsBackground/Objectives: The causes and mechanisms underlying the development of leptin resistance (LR) in patients with cardiovascular disease (CVD) remain unknown.
Olga Gruzdeva +8 more
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Leptin resistance: underlying mechanisms and diagnosis [PDF]
Diabetes, Metabolic Syndrome and Obesity, 2019 Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O +4 more
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Leptin receptor action and mechanisms of leptin resistance [PDF]
Cellular and Molecular Life Sciences, 2005 The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine function. Resistance to the appetite-suppressing effects of leptin is associated with common forms of obesity. Here, we review the mechanisms by which leptin activates intracellular signals and the roles that these signals play in leptin action in vivo.
Heike Münzberg +3 more
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Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions [PDF]
Endocrine ConnectionsLeptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance.
Wenjing Hu, Huijuan Zhu, Fengying Gong
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The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity [PDF]
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Tagleb S. Mazahreh +7 more
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Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications [PDF]
BiomedicinesBackground: Leptin, an adipokine essential for regulating energy balance, exerts important effects on brain function, notably within the hippocampus, a region integral to learning and memory.
Ismael Valladolid-Acebes
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The Phlorotannin-Rich Fraction of Ecklonia cava Extract Attenuated the Expressions of the Markers Related with Inflammation and Leptin Resistance in Adipose Tissue [PDF]
International Journal of Endocrinology, 2020 Obesity is associated with systemic chronic inflammation, and it induces central leptin resistance which blocks the appetite-suppressing effect of leptin and leptin resistance in adipocytes. In the present study, we evaluated the effects of Ecklonia cava
Myeongjoo Son +7 more
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Sildenafil ameliorates leptin resistance and normalizes lipid handling in the hypothalamic and adipose tissues of testosterone-exposed pregnant rats [PDF]
Heliyon, 2021 Leptin and hypothalamic-adipose lipid handling are relevant in determining the shift of metabolic activities. There are scanty findings connecting glucose dysregulation as a result of hyperandrogenism during gestation to hypothalamic-adipose axis and ...
Emmanuel Damilare Areola +9 more
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