Leptin signaling and leptin resistance. [PDF]
Med Rev (2021), 2022 With the prevalence of obesity and associated comorbidities, studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing interest. In 1994, the cloning of leptin was a milestone in metabolic research. As an adipocytokine,
Liu J, Lai F, Hou Y, Zheng R.
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STAT3 phosphorylation in central leptin resistance. [PDF]
Nutr Metab (Lond), 2021 Mechanism exploitation of energy homeostasis is urgently required because of the worldwide prevailing of obesity-related metabolic disorders in human being.
Liu H, Du T, Li C, Yang G.
europepmc +7 more sources
The Effects of Laparoscopic Sleeve Gastrectomy on the Parameters of Leptin Resistance in Obesity. [PDF]
Biomolecules, 2019 Obesity is a growing public health problem worldwide. Bariatric surgical procedures achieve the most sustainable and efficacious outcomes in the treatment of morbid obesity.
Mazahreh TS +7 more
europepmc +3 more sources
Leptin resistance: underlying mechanisms and diagnosis. [PDF]
Diabetes Metab Syndr Obes, 2019 Olga Gruzdeva,1,2 Daria Borodkina,3 Evgenya Uchasova,1 Yulia Dyleva,1 Olga Barbarash1,2 1Federal State Budgetary Institution, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; 2Federal State Budget ...
Gruzdeva O +4 more
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Leptin, Obesity, and Leptin Resistance: Where Are We 25 Years Later? [PDF]
Nutrients, 2019 Leptin, a hormone that is capable of effectively reducing food intake and body weight, was initially considered for use in the treatment of obesity.
Izquierdo AG +3 more
europepmc +8 more sources
Phlorotannins from Ecklonia cava Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons. [PDF]
Mar Drugs, 2019 Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance.
Oh S +6 more
europepmc +3 more sources
Establishment of Leptin-Responsive Cell Lines from Adult Mouse Hypothalamus. [PDF]
PLoS ONE, 2016 Leptin resistance is considered to be the primary cause of obesity. However, the cause of leptin resistance remains incompletely understood, and there is currently no cure for the leptin-resistant state.
Hiroshi Iwakura +6 more
doaj +25 more sources
Sulforaphane reduces obesity by reversing leptin resistance. [PDF]
Elife, 2022 The ascending prevalence of obesity in recent decades is commonly associated with soaring morbidity and mortality rates, resulting in increased health-care costs and decreased quality of life.
Çakır I +8 more
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CB1R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance. [PDF]
Elife, 2020 The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. Its reduced levels in diet-induced obesity (DIO) contributes to hyperleptinemia and leptin resistance, effects that are known to be ...
Drori A +10 more
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Effect of Lactobacillus rhamnosus GG on Energy Metabolism, Leptin Resistance, and Gut Microbiota in Mice with Diet-Induced Obesity. [PDF]
Nutrients, 2020 Obesity is closely associated with various metabolic disorders, including leptin resistance, which is characterized by high circulating leptin levels. Probiotics can decrease circulating leptin levels by alteration of the gut microbiota.
Cheng YC, Liu JR.
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