Results 31 to 40 of about 19,057 (244)
Genome organization by loop extrusion [PDF]
, 2018 All livings cells propagate in the same way - they duplicate their chromosomes and divide into two daughter cells, each containing one copy of each chromosome. Because of the extreme length of chromosomes, their two copies have be compacted in order to be successfully segregated from each other.
Goloborodko, Anton.
openaire +2 more sources
Compaction and segregation of sister chromatids via active loop extrusion [PDF]
eLife, 2016 The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can
Anton Goloborodko +3 more
doaj +3 more sources
Fundamental roles of chromatin loop extrusion in antibody class switching [PDF]
Nature, 2019 Antibody class switch recombination (CSR) in B lymphocytes replaces immunoglobulin heavy chain locus (Igh) Cμ constant region exons (CHs) with one of six CHs lying 100-200 kb downstream1. Each CH is flanked upstream by an I promoter and long repetitive switch (S) region1.
Zhang, Xuefei +5 more
openaire +6 more sources
The physical chemistry of interphase loop extrusion. [PDF]
Cell GenomAbstract Loop extrusion constitutes a universal mechanism of genome organization, whereby structural maintenance of chromosomes (SMC) protein complexes load onto the chromatin fiber and generate DNA loops of increasingly-larger sizes until their eventual release.
Tortora MMC, Fudenberg G.
europepmc +4 more sources
Transcription shapes 3D chromatin organization by interacting with loop extrusion [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2023 Edward Banigan +2 more
exaly +2 more sources
Loops and the activity of loop extrusion factors constrain chromatin dynamics. [PDF]
Mol Biol Cell, 2023 The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Bailey MLP +8 more
europepmc +4 more sources
Extrusion of chromatin loops by a composite loop extrusion factor [PDF]
Physical Review E, 2021 12 pages, 7 ...
Hao Yan +5 more
openaire +3 more sources
Function and Evolution of the Loop Extrusion Machinery in Animals. [PDF]
Int J Mol Sci, 2023 Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time ago.
Kabirova E +7 more
europepmc +3 more sources
3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion [PDF]
, 2022 International audienceAbstract Motivation Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo .
Gitchev, Todor +3 more
core +1 more source
Epigenetics & Chromatin, 2021 Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov +3 more
doaj +1 more source