Results 31 to 40 of about 18,925 (244)

Real-time imaging of DNA loop extrusion by condensin [PDF]

Science, 2018
It has been hypothesized that SMC protein complexes such as condensin and cohesin spatially organize chromosomes by extruding DNA into large loops. We directly visualized the formation and processive extension of DNA loops by yeast condensin in real time.
Shaltiel, Indra A. (author), Indra A. Shaltiel, Mahipal Ganji, Ganji, M., Bisht, Shveta (author), Cees Dekker, Haering, C., Kim, E., Haering, Christian H., Christian H. Haering, Eugene Kim, Dekker, C., Kim, E. (author), Shveta Bisht, Kim, E. ; https://orcid.org/, Shaltiel, Indra A., Ganji, M. (author), Haering, Christian H. (author), Kalichava, A., Ana Kalichava, Bisht, Shveta, Kalichava, A. (author), Bisht, S., Dekker, C. (author), Shaltiel, I.   +24 more
core   +6 more sources

Compaction and segregation of sister chromatids via active loop extrusion [PDF]

eLife, 2016
The mechanism by which chromatids and chromosomes are segregated during mitosis and meiosis is a major puzzle of biology and biophysics. Using polymer simulations of chromosome dynamics, we show that a single mechanism of loop extrusion by condensins can
Anton Goloborodko, Maxim V Imakaev, John F Marko, Leonid Mirny   +3 more
doaj   +2 more sources

The physical chemistry of interphase loop extrusion. [PDF]

Cell Genom
Abstract Loop extrusion constitutes a universal mechanism of genome organization, whereby structural maintenance of chromosomes (SMC) protein complexes load onto the chromatin fiber and generate DNA loops of increasingly-larger sizes until their eventual release.
Tortora MMC, Fudenberg G.
europepmc   +4 more sources

Transcription shapes 3D chromatin organization by interacting with loop extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Edward J Banigan, Aafke A Van Den Berg, Roman R Stocsits   +2 more
exaly   +2 more sources

Loops and the activity of loop extrusion factors constrain chromatin dynamics. [PDF]

Mol Biol Cell, 2023
The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Bailey MLP, Surovtsev I, Williams JF, Yan H, Yuan T, Li K, Duseau K, Mochrie SGJ, King MC.   +8 more
europepmc   +4 more sources

Extrusion of chromatin loops by a composite loop extrusion factor [PDF]

Physical Review E, 2021
12 pages, 7 ...
Hao Yan, Ivan Surovtsev, Jessica F. Williams, Mary Lou P. Bailey, Megan C. King, Simon G. J. Mochrie   +5 more
openaire   +3 more sources

Function and Evolution of the Loop Extrusion Machinery in Animals. [PDF]

Int J Mol Sci, 2023
Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time ago.
Kabirova E, Nurislamov A, Shadskiy A, Smirnov A, Popov A, Salnikov P, Battulin N, Fishman V.   +7 more
europepmc   +3 more sources

3DPolyS-LE: an accessible simulation framework to model the interplay between chromatin and loop extrusion [PDF]

, 2022
International audienceAbstract Motivation Recent studies suggest that the loop extrusion activity of Structural Maintenance of Chromosomes complexes is central to proper organization of genomes in vivo .
Gitchev, Todor, Zala, Gabriel, Meister, Peter, Jost, Daniel   +3 more
core   +1 more source

Sensitivity of cohesin–chromatin association to high-salt treatment corroborates non-topological mode of loop extrusion

Epigenetics & Chromatin, 2021
Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov, Anastasia V. Golova, Alexey A. Gavrilov, Sergey V. Razin   +3 more
doaj   +1 more source

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

eLife, 2020
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués   +3 more
doaj   +1 more source