Results 31 to 40 of about 19,126 (200)
Large domains of heterochromatin direct the formation of short mitotic chromosome loops
eLife, 2020 During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold.
Maximilian H Fitz-James +7 more
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Intrusion Effects on Maxillary Anteriors using Mini Implant Anchorage and K-Sir Loop in Subjects with Deep Overbite- A Cohort Study [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Various options to treat deep bites nonsurgically involve extrusion of posterior teeth or intrusion of anterior teeth. Intrusion of anterior teeth is required in patients with excessive incisal display and to correct deep bite in adult ...
Purva Verma, Ravindra Kumar Jain
doaj +1 more source
eLife, 2020 Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown.
Adrien Birot +8 more
doaj +1 more source
Active loop extrusion modulates the mechanical response of chromatin under tension
Physical Review ResearchChromosomes are complex biopolymers folded into dynamic loops via a loop-extrusion process and may experience various mechanical forces in vivo. We develop a force-dependent model of chromatin loop extrusion and investigate its mechanical consequences on
Hossein Salari, Daniel Jost
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A complex regulatory landscape involved in the development of mammalian external genitals
eLife, 2020 Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer–enhancer and enhancer–promoter interactions.
Ana Rita Amândio +4 more
doaj +1 more source
Condensin DC loads and spreads from recruitment sites to create loop-anchored TADs in C. elegans
eLife, 2022 Condensins are molecular motors that compact DNA via linear translocation. In Caenorhabditis elegans, the X-chromosome harbors a specialized condensin that participates in dosage compensation (DC).
Jun Kim +9 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
Nucleus, 2020 Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
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It’s all in the numbers: Cohesin stoichiometry
Frontiers in Molecular Biosciences, 2022 Cohesin, a structural maintenance of chromosome (SMC) complex, organizes chromatin into three-dimensional structures by threading chromatin into loops and stabilizing long-range chromatin interactions. Four subunits in a 1:1:1:1 ratio compose the cohesin
Avi Matityahu, Itay Onn
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source