Results 21 to 30 of about 713,910 (249)

Emerging Evidence of Chromosome Folding by Loop Extrusion [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2017
Chromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating ...
Imakaev, Maxim, Fudenberg, Geoffrey, Goloborodko, Anton, Abdennur, Nezar Alexander, Mirny, Leonid A., Leonid A. Mirny, Geoffrey Fudenberg, Nezar Abdennur, Maxim Imakaev, Anton Goloborodko   +9 more
core   +5 more sources

The interplay between asymmetric and symmetric DNA loop extrusion [PDF]

eLife, 2020
Chromosome compaction is essential for reliable transmission of genetic information. Experiments suggest that ∼1000-fold compaction is driven by condensin complexes that extrude chromatin loops, by progressively collecting chromatin fiber from one or ...
Edward J Banigan, Leonid A Mirny
doaj   +4 more sources

The physical chemistry of interphase loop extrusion. [PDF]

Cell Genom
Abstract Loop extrusion constitutes a universal mechanism of genome organization, whereby structural maintenance of chromosomes (SMC) protein complexes load onto the chromatin fiber and generate DNA loops of increasingly-larger sizes until their eventual release.
Tortora MMC, Fudenberg G.
europepmc   +4 more sources

Extrusion of chromatin loops by a composite loop extrusion factor [PDF]

Physical Review E, 2021
12 pages, 7 ...
Hao Yan, Ivan Surovtsev, Jessica F. Williams, Mary Lou P. Bailey, Megan C. King, Simon G. J. Mochrie   +5 more
openaire   +3 more sources

Genome organization by loop extrusion

, 2018
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Thesis: Ph.
Goloborodko, Anton.
core   +2 more sources

Loops and the activity of loop extrusion factors constrain chromatin dynamics. [PDF]

Mol Biol Cell, 2023
The relationship between chromatin structure and dynamics is incompletely understood. Here experimental and computational approaches are combined to reveal that looping interactions impose constraints on chromatin mobility while the ATP-dependent INO80 chromatin remodeler plays an important role in energy-dependent chromatin dynamics.
Bailey MLP, Surovtsev I, Williams JF, Yan H, Yuan T, Li K, Duseau K, Mochrie SGJ, King MC.   +8 more
europepmc   +4 more sources

Transcription Shapes 3D Chromatin Organization by Interacting With Loop Extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Edward J Banigan, Hugo B Brandão, Leonid Mirny   +2 more
exaly   +2 more sources

Function and Evolution of the Loop Extrusion Machinery in Animals. [PDF]

Int J Mol Sci, 2023
Structural maintenance of chromosomes (SMC) complexes are essential proteins found in genomes of all cellular organisms. Essential functions of these proteins, such as mitotic chromosome formation and sister chromatid cohesion, were discovered a long time ago.
Kabirova E, Nurislamov A, Shadskiy A, Smirnov A, Popov A, Salnikov P, Battulin N, Fishman V.   +7 more
europepmc   +3 more sources

Chromatin Loop Extrusion and Chromatin Unknotting [PDF]

Polymers, 2018
It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all chromosomes should reach the state of topological equilibrium.
Racko, Dusan, Benedetti, Fabrizio, Goundaroulis, Dimos, Stasiak, Andrzej   +3 more
openaire   +4 more sources

Loop-Extrusion-Mediated Plasmid DNA Cleavage by the Bacterial SMC Wadjet Complex [PDF]

Molecular Cell
Kevin D Corbett, Eugene Kim, Biswajit Pradhan   +2 more
exaly   +2 more sources