Results 21 to 30 of about 18,925 (244)

Chromosome organization by one-sided and two-sided loop extrusion

eLife, 2020
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny   +4 more
doaj   +2 more sources

SMC complexes: Lifting the lid on loop extrusion.

Current Opinion in Cell Biology, 2022
Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape chromosomes - single molecule in vitro observations have yielded fascinating images of this process.
Torahiko L Higashi (9219092), Frank Uhlmann (54006)   +1 more
core   +3 more sources

Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex [PDF]

Molecular Cell
Structural maintenance of chromosomes (SMC) complexes play pivotal roles in genome organization and maintenance across all domains of life. In prokaryotes, SMC-family Wadjet complexes structurally resemble the widespread MukBEF but serve a defensive role
Biswajit Pradhan, Amar Deep, Martin D Baaske   +2 more
exaly   +4 more sources

A Brownian ratchet model for DNA loop extrusion by the cohesin complex [PDF]

eLife, 2021
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities.
Torahiko L Higashi, Georgii Pobegalov, Minzhe Tang, Maxim I Molodtsov, Frank Uhlmann   +4 more
doaj   +3 more sources

Emerging Evidence of Chromosome Folding by Loop Extrusion [PDF]

Cold Spring Harbor Symposia on Quantitative Biology, 2019
Chromosome organization poses a remarkable physical problem with many biological consequences: How can molecular interactions between proteins at the nanometer scale organize micron-long chromatinized DNA molecules, insulating or facilitating ...
Imakaev, Maxim, Fudenberg, Geoffrey, Goloborodko, Anton, Abdennur, Nezar Alexander, Mirny, Leonid A.   +4 more
core   +4 more sources

Chromosome Compaction by Active Loop Extrusion [PDF]

Biophysical Journal, 2016
During cell division, chromosomes are compacted in length by more than a 100-fold. A wide range of experiments demonstrated that in their compacted state, mammalian chromosomes form arrays of closely stacked consecutive ∼100 kb loops.
Marko, John F., Goloborodko, Anton, Mirny, Leonid A, Mirny, Leonid A.   +3 more
core   +6 more sources

Active Loop Extrusion Guides DNA-Protein Condensation.

Physical Review Letters
The spatial organization of DNA involves DNA loop extrusion and the formation of protein-DNA condensates. While the significance of each process is increasingly recognized, their interplay remains unexplored.
Brugués, J., Takaki, R., Jülicher, F., Savich, Y.   +3 more
core   +5 more sources

Nuclear morphology is shaped by loop-extrusion programs. [PDF]

Nature
It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1–3. However, how polymorphonuclear structures are assembled remains unknown4.
Patta I, Zand M, Lee L, Mishra S, Bortnick A, Lu H, Prusty A, McArdle S, Mikulski Z, Wang HY, Cheng CS, Fisch KM, Hu M, Murre C.   +13 more
europepmc   +6 more sources

Active loop extrusion modulates the mechanical response of chromatin under tension

Physical Review Research
Chromosomes are complex biopolymers folded into dynamic loops via a loop-extrusion process and may experience various mechanical forces in vivo. We develop a force-dependent model of chromatin loop extrusion and investigate its mechanical consequences on
Hossein Salari, Daniel Jost
doaj   +2 more sources

Chromatin organization by an interplay of loop extrusion and compartmental segregation [PDF]

Proceedings of the National Academy of Sciences, 2019
Mammalian chromatin is spatially organized at many scales showing two prominent features in interphase: (i) alternating regions (1–10 Mb) of active and inactive chromatin that spatially segregate into different compartments, and (II) domains (
Nubler, Johannes, Fudenberg, Geoffrey, Imakaev, Maksim Viktorovich, Mirny, Leonid A, Abdennur, Nezar Alexander   +4 more
core   +6 more sources