Results 11 to 20 of about 19,126 (200)

Molecular dynamics simulations of human cohesin subunits identify DNA binding sites and their potential roles in DNA loop extrusion. [PDF]

PLoS Computational Biology
The SMC complex cohesin mediates interphase chromatin structural formation in eukaryotic cells through DNA loop extrusion. Here, we sought to investigate its mechanism using molecular dynamics simulations.
Chenyang Gu, Shoji Takada, Giovanni B Brandani, Tsuyoshi Terakawa   +3 more
doaj   +2 more sources

Theory of chromatin organization maintained by active loop extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Michael Rubinstein, Brian Chan
exaly   +2 more sources

Transcription shapes 3D chromatin organization by interacting with loop extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
Edward Banigan, Hugo Brandao, Leonid A Mirny   +2 more
exaly   +2 more sources

Function and Evolution of the Loop Extrusion Machinery in Animals [PDF]

International Journal of Molecular Sciences, 2023
Alexander Smirnov, Veniamin Fishman, Nariman Battulin   +2 more
exaly   +2 more sources

A Brownian ratchet model for DNA loop extrusion by the cohesin complex

eLife, 2021
The cohesin complex topologically encircles DNA to promote sister chromatid cohesion. Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation. Here, we propose a structure-based model explaining both activities.
Torahiko L Higashi, Georgii Pobegalov, Minzhe Tang, Maxim I Molodtsov, Frank Uhlmann   +4 more
doaj   +1 more source

Loop-extrusion-mediated plasmid DNA cleavage by the bacterial SMC Wadjet complex [PDF]

Molecular Cell
Kevin Corbett, Eugene Kim, Biswajit Pradhan   +2 more
exaly   +2 more sources

Sensitivity of cohesin–chromatin association to high-salt treatment corroborates non-topological mode of loop extrusion

Epigenetics & Chromatin, 2021
Cohesin is a key organizer of chromatin folding in eukaryotic cells. The two main activities of this ring-shaped protein complex are the maintenance of sister chromatid cohesion and the establishment of long-range DNA–DNA interactions through the process
Arkadiy K. Golov, Anastasia V. Golova, Alexey A. Gavrilov, Sergey V. Razin   +3 more
doaj   +1 more source

Chromosome organization by one-sided and two-sided loop extrusion

eLife, 2020
SMC complexes, such as condensin or cohesin, organize chromatin throughout the cell cycle by a process known as loop extrusion. SMC complexes reel in DNA, extruding and progressively growing DNA loops.
Edward J Banigan, Aafke A van den Berg, Hugo B Brandão, John F Marko, Leonid A Mirny   +4 more
doaj   +1 more source

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

eLife, 2020
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been proposed as a mechanism to organize chromatin in interphase and metaphase. However, the requirements for chromatin organization in these cell cycle phases are different, and
Stefan Golfier, Thomas Quail, Hiroshi Kimura, Jan Brugués   +3 more
doaj   +1 more source

Multi-feature clustering of CTCF binding creates robustness for loop extrusion blocking and Topologically Associating Domain boundaries

Nature Communications, 2023
Topologically Associating Domains (TADs) separate vertebrate genomes into insulated regulatory neighborhoods that focus genome-associated processes. TADs are formed by Cohesin-mediated loop extrusion, with many TAD boundaries consisting of clustered ...
Li-Hsin Chang, Sourav Ghosh, Andrea Papale, Jennifer M. Luppino, Mélanie Miranda, Vincent Piras, Jéril Degrouard, Joanne Edouard, Mallory Poncelet, Nathan Lecouvreur, Sébastien Bloyer, Amélie Leforestier, Eric F. Joyce, David Holcman, Daan Noordermeer   +14 more
doaj   +1 more source