Results 11 to 20 of about 18,925 (244)

Telomeres stall DNA loop extrusion by condensin

Cell Reports
Summary: DNA loop extrusion by SMC proteins is a key process underlying chromosomal organization. It is unknown how loop extruders interact with telomeres where DNA is densely covered with proteins.
Brian T. Analikwu, Alice Deshayes, Jaco van der Torre, Thomas M. Guérin, Allard J. Katan, Claire Béneut, Roman Barth, Jamie Phipps, Vittore Scolari, Xavier Veaute, Didier Busso, Karine Dubrana, Stefano Mattarocci, Cees Dekker, Stéphane Marcand   +14 more
doaj   +7 more sources

Formation of Chromosomal Domains by Loop Extrusion [PDF]

Cell Reports, 2016
Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation.
Geoffrey Fudenberg, Maxim Imakaev, Carolyn Lu, Anton Goloborodko, Nezar Abdennur, Leonid A. Mirny   +5 more
doaj   +7 more sources

Fluidification of entangled polymers by loop extrusion

Physical Review Research
Loop extrusion is one of the main processes shaping chromosome organization across the cell cycle, yet its role in regulating deoxyribonucleic acid (DNA) entanglement and nucleoplasm viscoelasticity remains overlooked.
Filippo Conforto, Yair Gutierrez Fosado, Davide Michieletto   +2 more
doaj   +3 more sources

Three-dimensional loop extrusion. [PDF]

Biophys J, 2021
Loop extrusion convincingly describes how certain Structural Maintenance of Chromosome (SMC) proteins mediate the formation of large DNA loops. Yet, most of the existing computational models cannot reconcile recent in vitro observations showing that ...
Bonato A, Michieletto D.
europepmc   +9 more sources

The interplay between asymmetric and symmetric DNA loop extrusion [PDF]

eLife, 2020
Chromosome compaction is essential for reliable transmission of genetic information. Experiments suggest that ∼1000-fold compaction is driven by condensin complexes that extrude chromatin loops, by progressively collecting chromatin fiber from one or ...
Edward J Banigan, Leonid A Mirny
doaj   +4 more sources

DNA double-strand break end synapsis by DNA loop extrusion [PDF]

Nature Communications, 2023
DNA double-strand breaks (DSBs) occur every cell cycle and must be repaired. Here the authors combine theory and simulations to establish a likely role for loop extrusion in bringing the DSB ends back into proximity for repair.
Jin H. Yang, Hugo B. Brandão, Anders S. Hansen   +2 more
doaj   +3 more sources

Condensin-driven loop extrusion on supercoiled DNA [PDF]

Nature Structural & Molecular Biology, 2022
Condensin, a structural maintenance of chromosomes (SMC) complex, has been shown to be a molecular motor protein that organizes chromosomes by extruding loops of DNA.
Pradhan, B., van der Torre, J., Dekker, C., Martin Gonzalez, A. (author), Kim, E. (author), van der Torre, J. (author), Kim, E., Pradhan, B. (author), Martin Gonzalez, A., Dekker, C. (author)   +9 more
core   +7 more sources

Theory of chromatin organization maintained by active loop extrusion [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2023
The active loop extrusion hypothesis proposes that chromatin threads through the cohesin protein complex into progressively larger loops until reaching specific boundary elements. We build upon this hypothesis and develop an analytical theory for active loop extrusion which predicts that loop formation probability is a nonmonotonic function of loop ...
Brian Chan, Michael Rubinstein
exaly   +4 more sources

Cohesin supercoils DNA during loop extrusion

Cell Reports
Cohesin extrudes genomic DNA into loops that promote chromatin assembly, gene regulation, and gene recombination. Loop extrusion depends on large-scale conformational changes in cohesin, but how these translocate DNA is poorly understood. Here, we provide evidence that cohesin negatively supercoils DNA during loop extrusion.
Jan-Michaél Peters
exaly   +5 more sources

Chromatin Loop Extrusion and Chromatin Unknotting [PDF]

Polymers, 2018
It has been a puzzle how decondensed interphase chromosomes remain essentially unknotted. The natural expectation is that in the presence of type II DNA topoisomerases that permit passages of double-stranded DNA regions through each other, all ...
Dimos Goundaroulis, Andrzej Stasiak, Fabrizio Benedetti, Dusan Racko   +3 more
core   +5 more sources