Results 41 to 50 of about 713,910 (249)

Effective model of loop extrusion predicts chromosomal domains [PDF]

Physical Review E, 2020
An active loop-extrusion mechanism is regarded as the main out--of--equilibrium mechanism responsible for the structuring of megabase-sized domains in chromosomes. We developed a model to study the dynamics of the chromosome fibre by solving the kinetic equations associated with the motion of the extruder.
Martina Crippa, Yinxiu Zhan, Guido Tiana
openaire   +4 more sources

Two CTCF Motifs Impede Cohesin-Mediated DNA Loop Extrusion

Molecular Cell
Cees Dekker, Roman Barth, Richard Janissen   +2 more
exaly   +2 more sources

TAD cliques predict key features of chromatin organization

BMC Genomics, 2021
Background Mechanisms underlying genome 3D organization and domain formation in the mammalian nucleus are not completely understood. Multiple processes such as transcriptional compartmentalization, DNA loop extrusion and interactions with the nuclear ...
Tharvesh M. Liyakat Ali, Annaël Brunet, Philippe Collas, Jonas Paulsen   +3 more
doaj   +1 more source

Testing pseudotopological and nontopological models for SMC-driven DNA loop extrusion against roadblock-traversal experiments

Scientific Reports, 2023
DNA loop extrusion by structural-maintenance-of-chromosome (SMC) complexes has emerged as a primary organizing principle for chromosomes. The mechanism by which SMC motor proteins extrude DNA loops is still unresolved and much debated.
Roman Barth, Biswajit Pradhan, Eugene Kim, Iain F. Davidson, Jaco van der Torre, Jan-Michael Peters, Cees Dekker   +6 more
doaj   +1 more source

DNA loop extrusion by human cohesin

Science, 2019
Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Davidson, Iain F., Bauer, Benedikt, Goetz, Daniela, Tang, Wen, Wutz, Gordana, Peters, Jan-Michael   +5 more
openaire   +2 more sources

Micro-extrusion of fine ceramic latticework [PDF]

, 2008
PhDMicroextrusion freeforming of ceramic lattices from high solids ceramic pastes is a method for forming complex multi-scale hierarchical porous structures.
Chi, Xiaopeng
core   +2 more sources

STAG2 promotes the myelination transcriptional program in oligodendrocytes

eLife, 2022
Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer–promoter interactions, among other mechanisms.
Ningyan Cheng, Guanchen Li, Mohammed Kanchwala, Bret M Evers, Chao Xing, Hongtao Yu   +5 more
doaj   +1 more source

Nuclear morphology is shaped by loop-extrusion programs. [PDF]

Nature
It is well established that neutrophils adopt malleable polymorphonuclear shapes to migrate through narrow interstitial tissue spaces1-3. However, how polymorphonuclear structures are assembled remains unknown4. Here we show that in neutrophil progenitors, halting loop extrusion-a motor-powered process that generates DNA loops by pulling in chromatin5 ...
Patta I, Zand M, Lee L, Mishra S, Bortnick A, Lu H, Prusty A, McArdle S, Mikulski Z, Wang HY, Cheng CS, Fisch KM, Hu M, Murre C.   +13 more
europepmc   +5 more sources

Osmotic mechanism of the loop extrusion process

Physical Review E, 2017
The loop extrusion theory assumes that protein factors, such as cohesin rings, act as molecular motors that extrude chromatin loops. However, recent single molecule experiments have shown that cohesin does not show motor activity. To predict the physical mechanism involved in loop extrusion, we here theoretically analyze the dynamics of cohesin rings ...
Yamamoto, T., Schiessel, H.
openaire   +5 more sources

Development of twin screw Rheo extrusion technology [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and was awarded by Brunel UniversityTwin Screw Rheo Extrusion (TSRE) is a novel semisolid extrusion process developed at BCAST for producing simple profiles such as rods and wires of light
Cassinath, Zen
core   +5 more sources