Results 51 to 60 of about 19,057 (244)
Condensin loop extrusion properties, roadblocks, and role in homology search in S. cerevisiae [PDF]
The in vivo mechanism, cis-acting roadblocks, and biological functions of loop extrusion by eukaryotic SMC complexes are incompletely defined. Here, we identify condensin-dependent Hi-C contact stripes at the Recombination Enhancer (RE) and the rDNA in S.
Piveteau V +6 more
europepmc +2 more sources
Effective model of loop extrusion predicts chromosomal domains [PDF]
Physical Review E, 2020 An active loop-extrusion mechanism is regarded as the main out--of--equilibrium mechanism responsible for the structuring of megabase-sized domains in chromosomes. We developed a model to study the dynamics of the chromosome fibre by solving the kinetic equations associated with the motion of the extruder.
Martina Crippa, Yinxiu Zhan, Guido Tiana
openaire +4 more sources
NIPBL and STAG1 enable loop extrusion by providing differential DNA-cohesin affinity. [PDF]
Proc Natl Acad Sci U S ADNA loop extrusion by cohesin has emerged as a critical pathway for chromosome organization. In vitro single-molecule experiments indicate that loop extrusion requires the assembly of a heteropentameric complex consisting of the SMC1/SMC3 heterodimer ...
van Wee R +8 more
europepmc +3 more sources
Polymer simulations guide the detection and quantification of chromatin loop extrusion by imaging. [PDF]
Nucleic Acids Res, 2023 International audienceAbstract Genome-wide chromosome conformation capture (Hi-C) has revealed the organization of chromatin into topologically associating domains (TADs) and loops, which are thought to help regulate genome functions.
Sabaté T +3 more
europepmc +2 more sources
Osmotic mechanism of the loop extrusion process
Physical Review E, 2017 The loop extrusion theory assumes that protein factors, such as cohesin rings, act as molecular motors that extrude chromatin loops. However, recent single molecule experiments have shown that cohesin does not show motor activity. To predict the physical mechanism involved in loop extrusion, we here theoretically analyze the dynamics of cohesin rings ...
Yamamoto, T., Schiessel, H.
openaire +4 more sources
DNA loop extrusion by human cohesin
Science, 2019 Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Davidson, Iain F. +5 more
openaire +2 more sources
The double loop mattress suture [PDF]
, 2014 © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ An interrupted stitch type with favorable tissue characteristics will reduce local wound complications.
Biddlestone, John +3 more
core +1 more source
STAG2 promotes the myelination transcriptional program in oligodendrocytes
eLife, 2022 Cohesin folds chromosomes via DNA loop extrusion. Cohesin-mediated chromosome loops regulate transcription by shaping long-range enhancer–promoter interactions, among other mechanisms.
Ningyan Cheng +5 more
doaj +1 more source
Human cohesin compacts DNA by loop extrusion [PDF]
Science, 2019 Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Yoori Kim +4 more
openaire +2 more sources
Epigenetics, 2021 DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-).
AM Raizis +5 more
doaj +1 more source