Results 51 to 60 of about 18,925 (244)
Polymer simulations guide the detection and quantification of chromatin loop extrusion by imaging. [PDF]
Nucleic Acids Res, 2023 International audienceAbstract Genome-wide chromosome conformation capture (Hi-C) has revealed the organization of chromatin into topologically associating domains (TADs) and loops, which are thought to help regulate genome functions.
Sabaté T +3 more
europepmc +2 more sources
Osmotic mechanism of the loop extrusion process
Physical Review E, 2017 The loop extrusion theory assumes that protein factors, such as cohesin rings, act as molecular motors that extrude chromatin loops. However, recent single molecule experiments have shown that cohesin does not show motor activity. To predict the physical mechanism involved in loop extrusion, we here theoretically analyze the dynamics of cohesin rings ...
Yamamoto, T., Schiessel, H.
openaire +4 more sources
The double loop mattress suture [PDF]
, 2014 © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ An interrupted stitch type with favorable tissue characteristics will reduce local wound complications.
Biddlestone, John +3 more
core +1 more source
DNA loop extrusion by human cohesin
Science, 2019 Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Davidson, Iain F. +5 more
openaire +2 more sources
Human cohesin compacts DNA by loop extrusion [PDF]
Science, 2019 Cohesin extrudes DNA loops DNA is folded into loops in eukaryotic cells by a process that depends on a ring-shaped adenosine triphosphatase complex called cohesin. Davidson et al. and Kim et al.
Yoori Kim +4 more
openaire +2 more sources
Dynamic 3D Locus Organization and Its Drivers Underpin Immunoglobulin Recombination
Frontiers in Immunology, 2021 A functional adaptive immune system must generate enormously diverse antigen receptor (AgR) repertoires from a limited number of AgR genes, using a common mechanism, V(D)J recombination.
Carolyn H. Rogers +2 more
doaj +1 more source
eLife, 2020 Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown.
Adrien Birot +8 more
doaj +1 more source
Epigenetics, 2021 DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-).
AM Raizis +5 more
doaj +1 more source
Intrusion Effects on Maxillary Anteriors using Mini Implant Anchorage and K-Sir Loop in Subjects with Deep Overbite- A Cohort Study [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Various options to treat deep bites nonsurgically involve extrusion of posterior teeth or intrusion of anterior teeth. Intrusion of anterior teeth is required in patients with excessive incisal display and to correct deep bite in adult ...
Purva Verma, Ravindra Kumar Jain
doaj +1 more source
A complex regulatory landscape involved in the development of mammalian external genitals
eLife, 2020 Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer–enhancer and enhancer–promoter interactions.
Ana Rita Amândio +4 more
doaj +1 more source