Results 61 to 70 of about 19,057 (244)
Dynamic 3D Locus Organization and Its Drivers Underpin Immunoglobulin Recombination
Frontiers in Immunology, 2021 A functional adaptive immune system must generate enormously diverse antigen receptor (AgR) repertoires from a limited number of AgR genes, using a common mechanism, V(D)J recombination.
Carolyn H. Rogers +2 more
doaj +1 more source
Intrusion Effects on Maxillary Anteriors using Mini Implant Anchorage and K-Sir Loop in Subjects with Deep Overbite- A Cohort Study [PDF]
Journal of Clinical and Diagnostic Research, 2020 Introduction: Various options to treat deep bites nonsurgically involve extrusion of posterior teeth or intrusion of anterior teeth. Intrusion of anterior teeth is required in patients with excessive incisal display and to correct deep bite in adult ...
Purva Verma, Ravindra Kumar Jain
doaj +1 more source
Large domains of heterochromatin direct the formation of short mitotic chromosome loops
eLife, 2020 During mitosis chromosomes reorganise into highly compact, rod-shaped forms, thought to consist of consecutive chromatin loops around a central protein scaffold.
Maximilian H Fitz-James +7 more
doaj +1 more source
eLife, 2020 Cohesin has essential roles in chromosome structure, segregation and repair. Cohesin binding to chromosomes is catalyzed by the cohesin loader, Mis4 in fission yeast. How cells fine tune cohesin deposition is largely unknown.
Adrien Birot +8 more
doaj +1 more source
Barrier effects on the kinetics of cohesin-mediated loop extrusion. [PDF]
Biophys JChromosome organization mediated by structural maintenance of chromosome complexes is crucial in many organisms. Cohesin extrudes chromatin into loops that are thought to lengthen until it is obstructed by CTCF proteins. In complex cellular environments, the loop extrusion machinery may encounter other chromatin-binding proteins.
Chen L +5 more
europepmc +3 more sources
Loop extrusion provides mechanical robustness to chromatin [PDF]
Chromosomes are complex biopolymers folded into dynamic loops via a loop extrusion process and may experience various mechanical forces in vivo . We develop a force-dependent model of chromatin loop extrusion and investigate its mechanical consequences ...
Salari, Hossein, Jost, Daniel
core +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
A complex regulatory landscape involved in the development of mammalian external genitals
eLife, 2020 Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer–enhancer and enhancer–promoter interactions.
Ana Rita Amândio +4 more
doaj +1 more source
CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
Nucleus, 2020 Mammalian genome structure is closely linked to function. At the scale of kilobases to megabases, CTCF and cohesin organize the genome into chromatin loops.
Anders S. Hansen
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source