Results 101 to 110 of about 10,818 (180)

Adaptive Genetic Variation in Black‐and‐White Snub‐Nosed Monkeys (Rhinopithecus bieti): Low Diversity and the Role of Balancing Selection

Ecology and Evolution, Volume 16, Issue 3, March 2026.
We investigated the adaptive genetic diversity within a population of Rhinopithecus bieti using amplicon sequencing. From 47 individuals, we identified 16 MHC class I sequences, revealing a low level of adaptive genetic variation. Although evidence for balancing selection, including positive selection and trans‐species polymorphism, was observed, these
Fei Long, Mei‐Jing Ying, Tian‐Qi Shi, Paul A. Garber, Ru‐Liang Pan, Jian‐Dong Lai, Zhi‐Pang Huang, Bao‐Guo Li, Pei Zhang   +8 more
wiley   +1 more source

RNA‐Based Therapies for Inherited Metabolic Disorders

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri, Sonam Gurung, Roopkatha Ghosh, Philippa B. Mills, Julien Baruteau, Haiyan Zhou   +5 more
wiley   +1 more source

RNA Regulatory Networks: Key Hubs in the Panorama of Cancer and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 3, March 2026.
RNA regulatory networks play a crucial role in the initiation and progression of cancer through various modes of RNA interactions. Notably, circulating RNAs have emerged as potential biomarkers, while targeted interventions in RNA regulatory networks facilitate precise therapeutic strategies. ABSTRACT Cancer is a global health challenge. The initiation
Xuan Yin, Zengkan Du, Shuya Jiang, Yan Liao, Changli Wang, Jiaqi Li, Haoling Zhang, Ting‐Ting Wei, Wangzheqi Zhang, Zui Zou   +9 more
wiley   +1 more source

Dinoflagellate mRNA is pervasively modified with m1A

EMBO Reports
N(1)-methyladenosine (m(1)A) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression. A new study in this issue now reports that m(1)A is abundant and dynamic in the 3′UTR of mRNAs of dinoflagellates, and could have an important role in post ...
Jianheng Fox Liu, Samie R Jaffrey
openaire   +2 more sources

Efficacy and Safety of DNV3 (a Lymphocyte‐activation Gene 3–blocking Antibody) Combined With Toripalimab and Chemotherapy in Advanced Melanoma: An Open‐label, Single‐arm Clinical Trial

MedComm, Volume 7, Issue 3, March 2026.
This investigator‐initiated trial demonstrates that LAG‐3/PD‐1 dual blockade (DNV3 + toripalimab) combined with chemotherapy achieves a 44.4% overall response rate (ORR) in advanced melanoma, showing particular efficacy in anti‐PD‐(L)1‐resistant patients (42.9% ORR, 7.36‐month median PFS), treatment‐naïve mucosal melanoma (50.0% ORR), and those with ...
Jing Lin, Lizhu Chen, Ling Chen, Dingyi Wang, Yuping Lu, Huishan Zhang, Ping Chen, Wei Yan, Zuoxiang Xiao, Yu Chen   +9 more
wiley   +1 more source

Investigating Communication Support Strategies as ‘Micro‐Interventions’: A Conceptual‐Methodological Framework Applying Realist Evaluation and Relevance Theory

International Journal of Language &Communication Disorders, Volume 61, Issue 2, March/April 2026.
ABSTRACT Background Communication Partner Training is widely applied in speech and language therapy practice, premised on the idea that communication support strategies can optimise conversations involving persons with communication disabilities.
Caroline Jagoe, Mirela Conica, Tim Wharton, Maria Zakaria   +3 more
wiley   +1 more source

Clinical Versus Pathologic Staging in Early‐Stage Non‐Small Cell Lung Cancer Assessed by an Established Lung Cancer Multidisciplinary Meeting

Thoracic Cancer, Volume 17, Issue 6, March 2026.
Clinical and pathological staging concordance in early‐stage NSCLC occurred in 73% of cases. Clinical under‐staging occurred in 18.9% of cases. Under‐staging was associated with treatment delays and tumor histopathology and increased the risk of disease recurrence and mortality.
James Nolan, Theron Sather, Craig Hukins, Michelle Murphy   +3 more
wiley   +1 more source

Reducing data processing effort in camera trap density estimation: Extending the REST model by explicitly modelling animal detection processes

Methods in Ecology and Evolution, Volume 17, Issue 3, Page 850-862, March 2026.
Abstract Accurate and reliable estimation of wildlife population density is fundamental to effective conservation and management. While camera traps show potential for monitoring ground‐dwelling mammal densities, labour‐intensive data processing remains a significant constraint. Ideally, conservation efforts would benefit from the continuous monitoring
Yoshihiro Nakashima, Gota Yajima, Ryo Matsuoka   +2 more
wiley   +1 more source

M1a Stage Finding [PDF]

, 2020
openaire   +1 more source

tRNA-m1A methylation controls the infection of Magnaporthe oryzae by supporting ergosterol biosynthesis

Developmental Cell
Ergosterols are essential components of fungal plasma membranes. Inhibitors targeting ergosterol biosynthesis (ERG) genes are critical for controlling fungal pathogens, including Magnaporthe oryzae, the fungus that causes rice blast. However, the translational mechanisms governing ERG gene expression remain largely unexplored.
Rongrong He, Ziwei Lv, Yinan Li, Shuchao Ren, Jiaqi Cao, Jun Zhu, Xinrong Zhang, Huimin Wu, Lihao Wan, Ji Tang, Shutong Xu, Xiao-Lin Chen, Zhipeng Zhou   +12 more
openaire   +2 more sources