Results 11 to 20 of about 10,818 (180)

M1a prostate cancer: Results of a Dutch multidisciplinary consensus meeting

BJUI Compass, 2021
Objectives To determine the consensus of a Dutch multidisciplinary expert panel on the diagnostic evaluation and treatment of de novo and recurrent metastatic prostate cancer (PCa) limited to non‐regional lymph nodes (M1a) in daily clinical practice ...
Shafak Aluwini, Daniela E. Oprea‐Lager, Hilda deBarros, Niven Mehra, Herman Stoevelaar, Derya Yakar, Henk van derPoel, Dutch M1a Prostate Cancer Working Group   +7 more
doaj   +3 more sources

Harnessing m1A modification: a new frontier in cancer immunotherapy

Frontiers in Immunology
N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang, Xiaoqing Ma, Siyu Chen, Minyan Fan, Chenying Jin, Yushi Chen, Shaodong Wang, Zhiying Wang, Fei Meng, Chengwan Zhang, Lin Yang   +10 more
doaj   +3 more sources

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]

BMC Gastroenterology, 2022
Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
doaj   +3 more sources

m1A Post‐Transcriptional Modification in tRNAs [PDF]

Biomolecules, 2017
To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Stephanie Oerum, Clément Dégut, Pierre Barraud, Carine Tisné   +3 more
doaj   +3 more sources

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Cancer Reports, 2023
Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Chunhui Jiang, Yuan Tian, Chunjie Xu, Hao Zhang, Lei Gu   +4 more
doaj   +3 more sources

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Cell & Bioscience
Background N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan   +9 more
doaj   +3 more sources

Comprehensive analyses of m1A regulator-mediated modification patterns determining prognosis in lower-grade glioma (running title: m1A in LGG)

Heliyon
N1-methyladenosine (m1A) modification is a crucial post-transcriptional regulatory mechanism of messenger RNA (mRNA) in living organisms. Few studies have focused on analysis of m1A regulators in lower-grade gliomas (LGG).
Kunjian Lei, Yilei Sheng, Min Luo, Junzhe Liu, Chuandong Gong, Shigang Lv, Wei Tu, Minhua Ye, Miaojing Wu, Bing xiao, Hua Fang, Haitao Luo, Xinjun Liu, Xiaoyan Long, Xingen Zhu, Kai Huang, Jingying Li   +16 more
doaj   +3 more sources

M1a/M1b esophageal carcinoma: Clinical relevance [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 1999
The 1997 staging system for esophageal carcinoma subdivides distant metastatic disease (M1) into M1a (nonregional lymph node metastases) and M1b (other metastases). This study evaluates the relevance of this classification.One hundred forty patients were identified with M1 disease, 36 (26%) M1a and 104 (74%) M1b.
Christie, Neil A., Rice, Thomas W., DeCamp, Malcolm M., Goldblum, John R., Adelstein, David J., Zuccaro, Gregory, Rybicki, Lisa A., Blackstone, Eugene H.   +7 more
openaire   +2 more sources

m¹A-Dependent TRMT6/61A-ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment. [PDF]

Adv Sci (Weinh)
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Li T, Huang M, Cai J, Li X, Xing Y, He R, Wan Z, Gan Y, Li Z, Weng J, Xie Y, Wu Y, Liu X, Wang X, Luo Y, Huang M, Lin J, Yu H.   +17 more
europepmc   +2 more sources

M1ARegpred: Epitranscriptome Target Prediction of N1-methyladenosine (m1A) Regulators Based on Sequencing Features and Genomic Features

Frontiers in Bioscience-Landmark, 2022
Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators.
Jia-Hui Yao, Meng-Xian Lin, Wen-Jun Liao, Wei-Jie Fan, Xiao-Xin Xu, Haoran Shi, Shu-Xiang Wu   +6 more
doaj   +1 more source